Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2418871406', 'doi': None, 'title': '[Effects and mechanisms of low concentration dopamine on hydrogen peroxide-induced apoptosis in cultured neonatal rat cardiomyocytes].', 'display_name': '[Effects and mechanisms of low concentration dopamine on hydrogen peroxide-induced apoptosis in cultured neonatal rat cardiomyocytes].', 'publication_year': 2015, 'publication_date': '2015-01-01', 'ids': {'openalex': 'https://openalex.org/W2418871406', 'mag': '2418871406', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26016244'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26016244', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028624558', 'display_name': 'Xiaona Cai', 'orcid': 'https://orcid.org/0000-0002-8080-779X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xiao-na Cai', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021014523', 'display_name': 'Sa Shi', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sa Shi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040924323', 'display_name': 'Hongzhu Li', 'orcid': 'https://orcid.org/0000-0002-1037-9101'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hong-zhu Li', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100385924', 'display_name': 'Lina Wang', 'orcid': 'https://orcid.org/0000-0001-8133-3349'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wang Li-na', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100339415', 'display_name': 'Hong Li', 'orcid': 'https://orcid.org/0000-0002-8240-7060'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hong Li', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.151, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.515231, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 76}, 'biblio': {'volume': '31', 'issue': '1', 'first_page': '67', 'last_page': '71'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.9501, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.9501, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9294, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9066, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7682235}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.6821485}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.630507}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5751453}, {'id': 'https://openalex.org/C533411734', 'wikidata': 'https://www.wikidata.org/wiki/Q171877', 'display_name': 'Hydrogen peroxide', 'level': 2, 'score': 0.5620002}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.48330832}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4741368}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.464036}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.45405084}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.42261705}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40072486}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39581499}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.33389276}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30341667}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27847058}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.16613105}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.16571778}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.107716024}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004298', 'descriptor_name': 'Dopamine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001552', 'descriptor_name': 'Benzazepines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053453', 'descriptor_name': 'Caspase 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053453', 'descriptor_name': 'Caspase 9', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004298', 'descriptor_name': 'Dopamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006861', 'descriptor_name': 'Hydrogen Peroxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007770', 'descriptor_name': 'L-Lactate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007770', 'descriptor_name': 'L-Lactate Dehydrogenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017447', 'descriptor_name': 'Receptors, Dopamine D1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017447', 'descriptor_name': 'Receptors, Dopamine D1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26016244', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3143982046', 'https://openalex.org/W2313271364', 'https://openalex.org/W2152593596', 'https://openalex.org/W2120946541', 'https://openalex.org/W2089103608', 'https://openalex.org/W2062579683', 'https://openalex.org/W2042772890', 'https://openalex.org/W2034255477', 'https://openalex.org/W2015327999', 'https://openalex.org/W1979059193'], 'abstract_inverted_index': {'To': [0], 'study': [1], 'the': [2, 19, 30, 132, 136, 192], 'effects': [3], 'of': [4, 93, 110, 138, 140, 194], 'low': [5, 42, 127, 174], 'concentration': [6, 43, 128, 175], 'dopamine(DA)': [7], 'on': [8], 'hydrogen': [9, 36, 124, 181], 'peroxide-induced': [10], 'apoptosis': [11, 71, 133, 141, 178], 'in': [12, 100, 183], 'cultured': [13], 'rat': [14, 24, 185], 'cardiomyocytes': [15, 25], 'as': [16, 18], 'well': [17], 'possible': [20], 'molecular': [21], 'mechanisms.Cultured': [22], 'neonatal': [23, 184], 'were': [26, 84, 118], 'randomly': [27], 'divided': [28], 'into': [29], 'following': [31], 'groups:': [32], 'control': [33], 'group': [34, 38, 53, 63], '(control),': [35], 'peroxide': [37, 125, 182], '(H2O2),': [39], 'pretreated': [40], 'with': [41, 123, 168, 191], 'dopamine': [44, 49, 59, 155, 169], '(': [45], 'DA': [46, 56, 66], '+': [47, 55, 57, 65, 67], 'H2O2),': [48, 58], 'receptor': [50, 60], 'l(DR1)': [51], 'antagonist': [52, 62, 151, 161], '(DR1': [54], '2(DR2)': [61], '(DR2': [64], 'H2O2).': [68], 'The': [69, 80, 91, 107], 'cell': [70, 101], 'was': [72, 103], 'then': [73], 'assessed': [74], 'by': [75, 86, 105, 120, 180], 'MTT': [76], 'and': [77, 115, 135], 'flow': [78], 'cytometry.': [79], 'cellular': [81], 'ultrastructure': [82], 'changes': [83, 166], 'observed': [85], 'transmission': [87], 'electron': [88], 'micro-': [89], 'scope.': [90], 'activity': [92], 'lactate': [94], 'dehydrogenase(LDH': [95], ')and': [96], 'superoxide': [97], 'dismutase': [98], '(SOD)': [99], 'medium': [102], 'analyzed': [104], 'colorimetry.': [106], 'protein': [108, 139], 'expressions': [109], 'Cytochrone': [111], 'c,': [112], 'Caspase': [113, 116], '3': [114], '9': [117], 'obtained': [119], 'Western': [121], 'blot.Compared': [122], 'group,': [126], 'dopamine(10': [129], 'µmol/L)': [130], 'decreased': [131, 147], 'rate': [134], 'expression': [137], 'related': [142], 'protein,': [143], 'enhanced': [144], 'SOD': [145], 'activity,': [146], 'LDH': [148], 'activity.': [149], 'DR1': [150], 'SCH-23390': [152], 'treatment': [153, 163], 'inhibited': [154], 'induced': [156, 179], 'cardiac': [157], 'protective': [158], 'effect.': [159], 'DR2': [160], 'haloperido': [162], 'had': [164], 'no': [165], 'compared': [167], 'group.Above': [170], 'findings': [171], 'indicate': [172], 'that': [173], 'dopanine': [176], 'inhibits': [177], 'cardiomyocytes,': [186], 'which': [187], 'is': [188], 'partly': [189], 'associated': [190], 'activation': [193], 'DR1.': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2418871406', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-16T19:32:55.413340', 'created_date': '2016-06-24'}