Title: A Pedigree Partitioning Approach to Quantitative Trait Loci Mapping of IgE Serum Level in the GAW12 Hutterite Data
Abstract: We present a semi-automatic method that uses principles from factor analysis to subdivide large pedigrees into smaller, non-overlapping sub-pedigrees. Application of our method to the Genetic Analysis Workshop 12 Hutterite pedigree yielded 12 sub-pedigrees that were used to carry out a genome-wide linkage scan for IgE serum level in SOLAR. Two-point analyses resulted in strong evidence for linkage to two marker loci on chromosome 1, D1S3723 (lod = 3.70) and D1S534 (lod = 3.58). Multipoint analysis resulted in a maximum lod of 4.58 on chromosome 1 at 143 cM. After extending the two pedigrees that contributed the most evidence for linkage, the maximum lod score decreased to 4.18, with most of the evidence for linkage due to a single large sub-pedigree.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 12
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