Publication Information

{'id': 'https://openalex.org/W2418471326', 'doi': 'https://doi.org/10.1055/s-2003-41109', 'title': 'Inhibitory Effect of Sterols from<i>Ruprechtia triflora</i>and Diterpenes from<i>Calceolaria pinnifolia</i>on the Growth of<i>Mycobacterium tuberculosis</i>', 'display_name': 'Inhibitory Effect of Sterols from<i>Ruprechtia triflora</i>and Diterpenes from<i>Calceolaria pinnifolia</i>on the Growth of<i>Mycobacterium tuberculosis</i>', 'publication_year': 2003, 'publication_date': '2003-07-01', 'ids': {'openalex': 'https://openalex.org/W2418471326', 'doi': 'https://doi.org/10.1055/s-2003-41109', 'mag': '2418471326', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12898418'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-2003-41109', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39653451', 'display_name': 'Planta Medica', 'issn_l': '0032-0943', 'issn': ['0032-0943', '1439-0221'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067388546', 'display_name': 'Girma M. Woldemichael', 'orcid': 'https://orcid.org/0000-0003-1823-1328'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Girma M Woldemichael', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Arizona, Tucson, AZ, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Arizona, Tucson, AZ, USA.', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052465031', 'display_name': 'Scott G. Franzblau', 'orcid': 'https://orcid.org/0000-0002-8698-0243'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Scott G Franzblau', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053340950', 'display_name': 'Fangqiu Zhang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Fangqiu Zhang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020701892', 'display_name': 'Yuehong Wang', 'orcid': 'https://orcid.org/0000-0002-1837-5252'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yuehong Wang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111986568', 'display_name': 'Barbara N. Timmermann', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Barbara N Timmermann', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.454, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.782477, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '69', 'issue': '7', 'first_page': '628', 'last_page': '631'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13221', 'display_name': 'Biological Activity of Diterpenoids and Biflavonoids', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13221', 'display_name': 'Biological Activity of Diterpenoids and Biflavonoids', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11385', 'display_name': 'Natural product bioactivities and synthesis', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13188', 'display_name': 'Synthesis and bioactivity of alkaloids', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/antimycobacterial', 'display_name': 'Antimycobacterial', 'score': 0.88741505}, {'id': 'https://openalex.org/keywords/ursolic-acid', 'display_name': 'Ursolic acid', 'score': 0.7190554}, {'id': 'https://openalex.org/keywords/terpene', 'display_name': 'Terpene', 'score': 0.68872076}, {'id': 'https://openalex.org/keywords/stigmasterol', 'display_name': 'Stigmasterol', 'score': 0.5657674}], 'concepts': [{'id': 'https://openalex.org/C2779685592', 'wikidata': 'https://www.wikidata.org/wiki/Q2853298', 'display_name': 'Antimycobacterial', 'level': 4, 'score': 0.88741505}, {'id': 'https://openalex.org/C2779513101', 'wikidata': 'https://www.wikidata.org/wiki/Q416260', 'display_name': 'Ursolic acid', 'level': 2, 'score': 0.7190554}, {'id': 'https://openalex.org/C44937612', 'wikidata': 'https://www.wikidata.org/wiki/Q212364', 'display_name': 'Terpene', 'level': 2, 'score': 0.68872076}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.6661401}, {'id': 'https://openalex.org/C2778858181', 'wikidata': 'https://www.wikidata.org/wiki/Q418628', 'display_name': 'Oleanolic acid', 'level': 3, 'score': 0.6414309}, {'id': 'https://openalex.org/C2778016309', 'wikidata': 'https://www.wikidata.org/wiki/Q425004', 'display_name': 'Stigmasterol', 'level': 2, 'score': 0.5657674}, {'id': 'https://openalex.org/C206103511', 'wikidata': 'https://www.wikidata.org/wiki/Q426694', 'display_name': 'Terpenoid', 'level': 2, 'score': 0.50513107}, {'id': 'https://openalex.org/C2778718757', 'wikidata': 'https://www.wikidata.org/wiki/Q143623', 'display_name': 'Sterol', 'level': 3, 'score': 0.49545562}, {'id': 'https://openalex.org/C2780527577', 'wikidata': 'https://www.wikidata.org/wiki/Q2915788', 'display_name': 'Triterpene', 'level': 3, 'score': 0.4885934}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45384568}, {'id': 'https://openalex.org/C176947019', 'wikidata': 'https://www.wikidata.org/wiki/Q597889', 'display_name': 'Minimum inhibitory concentration', 'level': 3, 'score': 0.4415244}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.44007936}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.39440572}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37471583}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.30838853}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2662127}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.23675}, {'id': 'https://openalex.org/C4937899', 'wikidata': 'https://www.wikidata.org/wiki/Q68541106', 'display_name': 'Antimicrobial', 'level': 2, 'score': 0.21443218}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.17371145}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.082333446}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.069200665}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004224', 'descriptor_name': 'Diterpenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019684', 'descriptor_name': 'Magnoliopsida', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010840', 'descriptor_name': 'Phytosterols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019664', 'descriptor_name': 'Polygonaceae', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001118', 'descriptor_name': 'Argentina', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004224', 'descriptor_name': 'Diterpenes', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D004224', 'descriptor_name': 'Diterpenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004224', 'descriptor_name': 'Diterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019684', 'descriptor_name': 'Magnoliopsida', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010840', 'descriptor_name': 'Phytosterols', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010840', 'descriptor_name': 'Phytosterols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010840', 'descriptor_name': 'Phytosterols', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019664', 'descriptor_name': 'Polygonaceae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-2003-41109', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39653451', 'display_name': 'Planta Medica', 'issn_l': '0032-0943', 'issn': ['0032-0943', '1439-0221'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12898418', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.44, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2798015016', 'https://openalex.org/W2393137560', 'https://openalex.org/W2388987551', 'https://openalex.org/W2388873731', 'https://openalex.org/W2382329877', 'https://openalex.org/W2378927827', 'https://openalex.org/W2373414729', 'https://openalex.org/W2369856369', 'https://openalex.org/W2358357018', 'https://openalex.org/W2354447643'], 'abstract_inverted_index': {'Bioactivity-guided': [0], 'fractionation': [1], 'of': [2, 6, 10, 18, 36, 40, 43, 62, 133, 153], 'the': [3, 7, 16, 25, 33, 44, 60, 125, 137, 159], 'CH2Cl2/MeOH': [4], 'extract': [5], 'aerial': [8], 'part': [9], 'Ruprechtia': [11], 'triflora': [12, 104], 'Griseb.': [13], 'led': [14], 'to': [15, 107, 171], 'identification': [17], 'several': [19, 81], 'sterols': [20, 101], 'and': [21, 55, 76, 122, 143, 163, 174], 'a': [22, 37, 41, 96], 'triterpene': [23], 'as': [24], 'active': [26, 109, 147], 'components': [27], 'against': [28], 'Mycobacterium': [29], 'tuberculosis.': [30], 'This': [31], 'is': [32], 'first': [34], 'report': [35], 'chemical': [38], 'investigation': [39], 'member': [42], 'genus': [45], 'Ruprechtia.': [46], 'The': [47], 'novel': [48], 'acylated': [49], 'sterol,': [50], '5α,8α-epidioxyergosta-6,22-dien-3β-yl': [51], 'stearate,': [52], 'was': [53], 'isolated': [54], 'its': [56], 'structure': [57], 'determined': [58, 170], 'on': [59], 'basis': [61], 'spectral': [63], 'evidence': [64], 'including': [65], 'NMR': [66], '(especially': [67], 'selective': [68, 71], '1D': [69, 72], 'NOE,': [70], 'TOCSY,': [73], 'HSQC,': [74], 'HMBC)': [75], 'MS': [77], '(HR-FAB).': [78], 'In': [79, 95], 'addition,': [80], 'terpenes': [82], 'obtained': [83], 'from': [84, 102, 114, 139, 166], 'Calceolaria': [85], 'pinnifolia': [86, 168], 'Cav.': [87], 'were': [88, 105, 145, 169], 'also': [89], 'evaluated': [90], 'for': [91, 158], 'their': [92], 'antimycobacterial': [93], 'activity.': [94], 'microplate': [97], 'alamar': [98], 'blue': [99], 'assay,': [100], 'R.': [103], 'found': [106], 'be': [108, 172], 'with': [110, 119, 129, 149], 'MIC': [111, 131, 151, 156], 'values': [112, 157], 'ranging': [113], '2': [115, 134], '-': [116], '128': [117], 'μg/mL,': [118, 176], '5α,8α-epidioxyergost-6,22-dien-3β-ol,': [120], '5α,8α-epidioxystigmasta-6,22-dien-3β-ol': [121], 'stigmast-4-en-6β-ol-3-one': [123], 'being': [124], 'most': [126, 146], 'active,': [127], 'each': [128, 148], 'an': [130, 150], 'value': [132, 152], 'μg/mL.': [135, 155], 'Among': [136], 'diterpenes': [138], 'C.': [140, 167], 'pinnifolia,': [141], '19-malonyloxydehydroabietinol': [142], '19-methylmalonyloxy-ent-isopimara-8(9),15-diene': [144], '4': [154], 'triterpenes': [160], '3-epi-ursolic': [161], 'acid': [162, 165], '3-epi-oleanolic': [164], '8': [173], '16': [175], 'respectively.': [177]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2418471326', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-12T12:25:17.041723', 'created_date': '2016-06-24'}