Publication Information

{'id': 'https://openalex.org/W2418404479', 'doi': None, 'title': 'Isolation and identification of metabolites of leukotriene A4 hydrolase inhibitor SC-57461 in rats.', 'display_name': 'Isolation and identification of metabolites of leukotriene A4 hydrolase inhibitor SC-57461 in rats.', 'publication_year': 1996, 'publication_date': '1996-10-01', 'ids': {'openalex': 'https://openalex.org/W2418404479', 'mag': '2418404479', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8894515'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8894515', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002252581', 'display_name': 'Jun Yuan', 'orcid': 'https://orcid.org/0000-0002-3908-6521'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. 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'score': 0.43, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4210345244', 'https://openalex.org/W3173417825', 'https://openalex.org/W2938024481', 'https://openalex.org/W2885456330', 'https://openalex.org/W2418363275', 'https://openalex.org/W2136275918', 'https://openalex.org/W2084635424', 'https://openalex.org/W2026368317', 'https://openalex.org/W1986869415', 'https://openalex.org/W1517084809'], 'abstract_inverted_index': {'The': [0, 27, 52, 101, 142, 173], 'metabolic': [1], 'fate': [2, 175], 'of': [3, 11, 30, 80, 85, 93, 124, 169, 176, 190, 201, 238], 'SC-57461,': [4, 155], 'N-methyl-N-[3-[4-(phenylmethyl)-phenoxy]propyl]-beta-alanine,': [5], 'a': [6, 166, 188, 198], 'potent': [7], 'and': [8, 21, 47, 64, 75, 98, 104, 112, 128, 216, 231], 'specific': [9], 'inhibitor': [10], 'the': [12, 35, 38, 41, 44, 48, 61, 81, 86, 91, 94, 110, 118, 125, 132, 150, 161, 177, 212, 217, 234], 'leukotriene': [13, 228], 'A4': [14, 229], 'hydrolase,': [15], 'was': [16, 55, 67, 138, 146, 181], 'determined': [17], 'by': [18, 140, 154], 'LC/MS/MS,': [19], 'NMR': [20], 'GC/MS': [22], 'in': [23, 32, 60, 69, 109, 117, 119, 135, 171, 240], 'male': [24], 'Sprague-Dawley': [25], 'rats.': [26, 172, 241], 'major': [28, 235], 'metabolites': [29, 237], 'SC-57461': [31, 170, 239], 'rats': [33], 'were': [34, 107, 220, 233], 'desmethyl': [36], 'metabolite,': [37, 40, 43, 46, 157, 163], 'hydroxylated': [39, 214], 'N-oxide': [42, 53, 133, 156], 'hydroxylamine': [45, 96, 102, 126, 162], 'propionic': [49, 143, 178, 196], 'acid': [50, 106, 130, 144, 179], 'metabolite.': [51], 'metabolite': [54, 103, 127, 134, 145, 152, 180, 215, 219], 'found': [56, 147, 221], 'to': [57, 90, 148, 194, 222], 'be': [58, 115, 149, 205], 'stable': [59], 'rat': [62, 184, 208], 'plasma': [63], 'urine,': [65], 'but': [66], 'unstable': [68], 'most': [70], 'organic': [71], 'solvents': [72], '(methanol,': [73], 'acetonitrile,': [74], 'methylene': [76, 136], 'chloride,': [77], 'etc.)': [78], 'because': [79], 'classic': [82], 'Cope': [83], 'reaction': [84], 'N-oxide,': [87], 'which': [88, 164], 'led': [89], 'formation': [92, 123], 'corresponding': [95], 'product': [97], 'acrylic': [99, 105, 129], 'acid.': [100], 'reactive': [108], 'biomatrix': [111], 'could': [113], 'not': [114], 'isolated': [116, 213], 'vivo': [120], 'samples.': [121], 'However,': [122], 'from': [131], 'chloride': [137], 'verified': [139], 'NMR.': [141], 'common': [151], 'shared': [153], 'as': [158, 160, 187], 'well': [159], 'suggested': [165], 'sequential': [167], 'metabolism': [168, 186], 'ultimate': [174], 'incorporation': [182], 'into': [183, 207], 'glycerolipid': [185, 209], 'result': [189], 'its': [191], 'structural': [192], 'similarity': [193], 'aryl-substituted': [195], 'acid,': [197], 'known': [199], 'class': [200], 'compounds': [202], 'that': [203], 'can': [204], 'incorporated': [206], 'metabolism.': [210], 'Finally,': [211], 'N-desmethyl': [218], 'have': [223], 'excellent': [224], 'inhibitory': [225], 'effects': [226], 'toward': [227], 'hydrolase': [230], 'therefore': [232], 'active': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2418404479', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T09:08:29.063363', 'created_date': '2016-06-24'}