A Novel Enzymatic Strategy for the Synthesis of Substituted Tetrahydroisoquinolines

Name: Work Video:
Duration: 3 min 30 s
Alessandra Bonamore; Lorenzo Calisti; Andrea Calcaterra; Omar H. Ismail; Maurizio Gargano; Ilaria D’Acquarica; Bruno Botta; Alberto Boffi; Alberto Macone
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82, 85, 99, 103, 108, 112, 124], 'activity': [26], 'plant': [29], 'diamine': [30, 71], 'oxidase': [31, 72], 'with': [32, 106, 153], 'recombinant': [34], 'norcoclaurine': [35, 86], 'synthase': [36, 87], 'enzyme': [37, 73], 'Thalictrum': [39], 'flavum': [40], '.': [41, 77], 'In': [42, 78], 'first': [44, 104], 'step,': [45, 81], 'variety': [47], 'aliphatic': [49], 'aromatic': [51], 'amines': [52], 'general': [54], 'interest': [55], 'as': [56], 'pharmaceutical': [57], 'building': [58], 'blocks': [59], 'were': [60, 117, 128, 139], 'transformed': [61], 'into': [62], 'corresponding': [64], 'aldehydes': [65], 'broad': [68], 'specificity': [69], 'Lathyrus': [75], 'cicera': [76], 'second': [80], 'stereoselectivity': [83], 'catalyzed': [88], 'reaction': [89], 'to': [90], 'yield': [91], '(S)‐configured': [92], 'tetrahydroisoquinoline': [93], 'products': [94, 125], 'exploited': [96], 'mixing': [98], 'aldehyde': [100], 'obtained': [101, 127, 140], 'step': [105], 'dopamine,': [107], 'committed': [109], 'substrate': [110], 'for': [111, 141], 'Pictet‐Spengler': [113], 'reaction.': [114], 'The': [115, 145], 'reactions': [116], 'carried': [118], 'out': [119], 'aqueous': [121], 'buffer': [122], 'thus': [126], 'extracted': [129], 'characterized': [131], 'chiral': [133], 'GC/MS.': [134], 'Enantiomeric': [135], 'excess': [136], '&gt;': [137], '99%': [138], 'all': [142], 'investigated.': [144], 'method': [146], 'provided': [147], 'novel': [151], 'potentially': [154], 'interesting': [155], 'pharmacological': [156], 'profiles.': [157]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2418372995', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-12-13T00:17:09.374868', 'created_date': '2016-06-24'}
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