Title: [Correlation of Helicobacter pylori infection with the expression of COX-2 and EGFR and VEGF in human gastric carcinoma].
Abstract: Objective To investigate the correlation of Helicobactor trylori (Hp) infection with the expression of COX-2, EGFR and VEGF in human gastric carcinoma. Methods The expression of COX-2, EGFR and VEGF was detected by immunohistocbemistry in samples of 61 gastric cancers and 20 canceradjacent tissues. Western blotting was performed in samples of 10 gastric cancers and corresponding canceradjacent tissues. Hp infection was detected in 47 patients by fast urea enzyme test and 13C breath test. Results The results of immunohistochemistry showed that the positive expressions of COX-2, EGFR and VEGF in gastric carcinoma were 59.02%, 36.07% and 60.66% ,respectively, significantly higher than that in the normal mucosa (25.00%, 0 and 30.00%, respectively). There was a positive correlation between the expression of COX-2, EGFR and VEGF and gastric carcinoma. The expression of COX-2 and EGFR was 75.76% and 45.45% in the gastric carcinomas with Hp infection, significantly higher than that in those without (28.57% and 14.29% ). The protein expression of COX-2, EGFR and VEGF detected by Western blot in gastric carcinomas was also significantly higher than that in normal mueosa. Conclusion COX-2, EGFR and VEGF are overexpressed in gastric carcinoma, and there is a positive correlation among them. Hp infection may upregulate the expression of COX-2 and EGFR in gastric cancer tissues.
Key words:
Gastric neoplasms; COX-2 ; EGFR; VEGF; Helicobacter pylori
Publication Year: 2008
Publication Date: 2008-09-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 1
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