Title: Interaction of the ligand molecules with the membrane receptors of tumor cells
Abstract: The mechanism of the ligand molecule interaction with cell membrane receptors is considered. The equation is obtained which describes dynamics of change in the number of ligand-receptor complexes on membranes with their constant internalization. It is shown that the in vivo internalization leads to saturation of the cell surface with the ligand-receptor complexes, the ligand concentrations being less than Kd. Theoretical conclusions are compared with the experimental data.
Publication Year: 1989
Publication Date: 1989-01-01
Language: en
Type: article
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