Title: Prediction of steady‐state imipramine and desmethylimipramine plasma concentrations from single‐dose data
Abstract: Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DM1) or imipramine (IMl) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady‐state plasma levels. In patients receiving DM1 there was a correlation (r = 0.97, n = 10) between 24‐hr and steady‐state DM1 levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24‐hr and steady‐state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a “therapeutic” dosage regimen without delay.
Publication Year: 1979
Publication Date: 1979-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 50
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot