Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2417756525', 'doi': 'https://doi.org/10.1055/s-0038-1650175', 'title': 'Comparison of the Relative Fibrinogenolytic, Fibrinolytic and Thrombolytic Properties of Tissue Plasminogen Activator and Urokinase in Vitro', 'display_name': 'Comparison of the Relative Fibrinogenolytic, Fibrinolytic and Thrombolytic Properties of Tissue Plasminogen Activator and Urokinase in Vitro', 'publication_year': 1981, 'publication_date': '1981-01-01', 'ids': {'openalex': 'https://openalex.org/W2417756525', 'doi': 'https://doi.org/10.1055/s-0038-1650175', 'mag': '2417756525', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7025339'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0038-1650175', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206235894', 'display_name': 'Thrombosis and Haemostasis', 'issn_l': '0340-6245', 'issn': ['0340-6245', '2567-689X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009408667', 'display_name': 'Osamu Matsuo', 'orcid': 'https://orcid.org/0000-0002-9806-2204'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'O Matsuo', 'raw_affiliation_strings': ['The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035254428', 'display_name': 'D.C. Rijken', 'orcid': 'https://orcid.org/0000-0002-7346-1129'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'D C Rijken', 'raw_affiliation_strings': ['The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110444371', 'display_name': 'Désiré Collen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'D Collen', 'raw_affiliation_strings': ['The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'The Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.818, 'has_fulltext': False, 'cited_by_count': 172, 'citation_normalized_percentile': {'value': 0.973365, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '45', 'issue': '03', 'first_page': '225', 'last_page': '229'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11721', 'display_name': 'Blood properties and coagulation', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11570', 'display_name': 'Periodontal Regeneration and Treatments', 'score': 0.9716, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/t-plasminogen-activator', 'display_name': 'T-plasminogen activator', 'score': 0.41083914}], 'concepts': [{'id': 'https://openalex.org/C2776892390', 'wikidata': 'https://www.wikidata.org/wiki/Q7119591', 'display_name': 'Urokinase', 'level': 2, 'score': 0.8491532}, {'id': 'https://openalex.org/C2776825266', 'wikidata': 'https://www.wikidata.org/wiki/Q1410794', 'display_name': 'Fibrinolysis', 'level': 2, 'score': 0.82492447}, {'id': 'https://openalex.org/C2779036427', 'wikidata': 'https://www.wikidata.org/wiki/Q381899', 'display_name': 'Fibrinogen', 'level': 2, 'score': 0.79693663}, {'id': 'https://openalex.org/C2779679481', 'wikidata': 'https://www.wikidata.org/wiki/Q13581432', 'display_name': 'Plasminogen activator', 'level': 2, 'score': 0.75188005}, {'id': 'https://openalex.org/C54173615', 'wikidata': 'https://www.wikidata.org/wiki/Q27205', 'display_name': 'Fibrin', 'level': 2, 'score': 0.7345191}, {'id': 'https://openalex.org/C2776572282', 'wikidata': 'https://www.wikidata.org/wiki/Q416351', 'display_name': 'Tissue plasminogen activator', 'level': 2, 'score': 0.6144566}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5838493}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.42932892}, {'id': 'https://openalex.org/C2909373784', 'wikidata': 'https://www.wikidata.org/wiki/Q416351', 'display_name': 'T-plasminogen activator', 'level': 3, 'score': 0.41083914}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3958994}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.36014307}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.26383036}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24839866}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24322459}], 'mesh': [{'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D005342', 'descriptor_name': 'Fibrinolysis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010960', 'descriptor_name': 'Plasminogen Activators', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014568', 'descriptor_name': 'Urokinase-Type Plasminogen Activator', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005342', 'descriptor_name': 'Fibrinolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005343', 'descriptor_name': 'Fibrinolytic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007457', 'descriptor_name': 'Iodine Radioisotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007553', 'descriptor_name': 'Isotope Labeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D010958', 'descriptor_name': 'Plasminogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010958', 'descriptor_name': 'Plasminogen', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D010960', 'descriptor_name': 'Plasminogen Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014568', 'descriptor_name': 'Urokinase-Type Plasminogen Activator', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000979', 'descriptor_name': 'alpha-2-Antiplasmin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000979', 'descriptor_name': 'alpha-2-Antiplasmin', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0038-1650175', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206235894', 'display_name': 'Thrombosis and Haemostasis', 'issn_l': '0340-6245', 'issn': ['0340-6245', '2567-689X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7025339', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1487281523', 'https://openalex.org/W1540618467', 'https://openalex.org/W1561931582', 'https://openalex.org/W1594701033', 'https://openalex.org/W1978579910', 'https://openalex.org/W1979941203', 'https://openalex.org/W1986317812', 'https://openalex.org/W1989861077', 'https://openalex.org/W2012839797', 'https://openalex.org/W2026994951', 'https://openalex.org/W2028670834', 'https://openalex.org/W2029352841', 'https://openalex.org/W2039045626', 'https://openalex.org/W2053192974', 'https://openalex.org/W2059543787', 'https://openalex.org/W2084667370', 'https://openalex.org/W2085649019', 'https://openalex.org/W2086778072', 'https://openalex.org/W2153718410', 'https://openalex.org/W2238866276', 'https://openalex.org/W2333867246', 'https://openalex.org/W2400695267', 'https://openalex.org/W2407142497', 'https://openalex.org/W2412255576', 'https://openalex.org/W2462810404', 'https://openalex.org/W2472331521', 'https://openalex.org/W2945485673'], 'related_works': ['https://openalex.org/W2466223857', 'https://openalex.org/W2417756525', 'https://openalex.org/W2408511292', 'https://openalex.org/W2209703901', 'https://openalex.org/W2141383969', 'https://openalex.org/W2093841689', 'https://openalex.org/W2077401978', 'https://openalex.org/W2028816956', 'https://openalex.org/W2027466922', 'https://openalex.org/W2017700181'], 'abstract_inverted_index': {'The': [0, 41], 'relative': [1], 'fibrinogenolytic,': [2], 'fibrinolytic': [3, 92, 178, 246], 'and': [4, 12, 24, 68, 187, 206, 259, 285], 'thrombolytic': [5], 'properties': [6], 'of': [7, 29, 53, 63, 65, 101, 108, 143, 151, 161, 166, 176, 185, 200, 216, 234, 244, 255], 'human': [8, 13, 22, 32, 39, 42, 55, 277, 290], 'tissue': [9, 43, 77, 111, 124, 167, 278], 'plasminogen': [10, 44, 67, 78, 112, 125, 134, 168, 186, 279], 'activator': [11, 45, 79, 109, 113, 126, 135, 169, 280], 'urokinase': [14, 152, 217, 235], 'were': [15, 211], 'compared': [16], 'in': [17, 20, 25, 37, 74, 173, 228], 'purified': [18, 48, 60], 'systems,': [19], 'whole': [21, 75], 'plasma': [23, 97], 'a': [26, 30, 54, 141, 183, 253, 282], 'system': [27, 179, 247], 'composed': [28, 62], 'radioactive': [31], 'blood': [33], 'clot': [34], '(125I-fibrinogen)': [35], 'hanging': [36], 'circulating': [38, 96], 'plasma.': [40], 'was': [46, 103, 153, 248, 262], 'highly': [47], 'from': [49, 182], 'the': [50, 95, 99, 106, 177, 245], 'culture': [51], 'fluid': [52], 'melanoma': [56], 'cell': [57], 'line.': [58], 'In': [59, 94, 122], 'systems': [61], 'fibrinogen': [64, 84, 131], 'fibrin,': [66], 'alpha': [69, 188, 257], '2-antiplasmin': [70, 189, 258], 'as': [71, 73, 180, 250], 'well': [72], 'plasma,': [76], 'digested': [80], 'fibrin': [81], 'without': [82], 'degrading': [83], 'significantly.': [85], 'Urokinase': [86], 'did': [87], 'not': [88], 'have': [89], 'this': [90], 'specific': [91, 284], 'effect.': [93], 'system,': [98], 'degree': [100], 'fibrinolysis': [102, 195, 266], 'proportional': [104], 'to': [105, 128, 190, 197], 'amount': [107, 215], 'added,': [110], 'being': [114], 'about': [115], '10': [116, 144], 'times': [117], 'more': [118, 283], 'efficient': [119], 'than': [120, 289], 'urokinase.': [121, 291], 'addition,': [123], 'appeared': [127], 'cause': [129], 'negligible': [130], 'degradation.': [132], 'Tissue': [133], 'still': [136], 'induced': [137, 223], 'significant': [138], 'thrombolysis': [139], 'at': [140, 155], 'concentration': [142], 'IU': [145, 157, 163, 219, 237], 'per': [146, 158, 170, 220, 238], 'ml': [147, 171, 239], 'whereas': [148], 'no': [149], 'effect': [150], 'observed': [154], '20': [156], 'ml.': [159], 'Infusion': [160], '100': [162], '(1': [164], 'microgram)': [165], 'resulted': [172], 'moderate': [174], 'activation': [175, 243], 'judged': [181], 'decrease': [184], '40-50': [191], 'percent.': [192], 'Nevertheless,': [193], 'extensive': [194, 242, 265], '(50': [196], '80': [198], 'percent': [199, 226, 269], 'radioactivity': [201], 'released': [202], 'after': [203, 270], '12': [204, 229, 271], 'hrs)': [205], 'only': [207, 222], 'very': [208], 'limited': [209], 'fibrinogenolysis': [210], 'observed.': [212], 'An': [213], 'equivalent': [214], '(100': [218], 'ml)': [221], 'approximately': [224], '15': [225], 'lysis': [227], 'hrs.': [230], 'At': [231], 'higher': [232], 'concentrations': [233], '(260': [236], 'or': [240], 'more)': [241], 'obtained': [249], 'evidenced': [251], 'by': [252], 'depletion': [254], 'plasminogen,': [256], 'fibrinogen.': [260], 'This': [261], 'associated': [263], 'with': [264], '(approximately': [267], '60': [268], 'hrs).': [272], 'It': [273], 'is': [274, 281], 'concluded': [275], 'that': [276], 'effective': [286], 'fibrinolytic-thrombolytic': [287], 'agent': [288]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2417756525', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-11T06:55:48.598630', 'created_date': '2016-06-24'}