Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2416981671', 'doi': 'https://doi.org/10.1136/annrheumdis-2015-eular.6444', 'title': 'THU0258 Adverse Effects of Biologics in Rheumatoid Arthritis: are they Different from Spondyloarthritis?', 'display_name': 'THU0258 Adverse Effects of Biologics in Rheumatoid Arthritis: are they Different from Spondyloarthritis?', 'publication_year': 2015, 'publication_date': '2015-06-01', 'ids': {'openalex': 'https://openalex.org/W2416981671', 'doi': 'https://doi.org/10.1136/annrheumdis-2015-eular.6444', 'mag': '2416981671'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1136/annrheumdis-2015-eular.6444', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25650217', 'display_name': 'Annals of the Rheumatic Diseases', 'issn_l': '0003-4967', 'issn': ['0003-4967', '1468-2060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077589111', 'display_name': 'S. Jradi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118449', 'display_name': 'Hôpital Charles-Nicolle', 'ror': 'https://ror.org/02f6ghw27', 'country_code': 'TN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210118449']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'S. Jradi', 'raw_affiliation_strings': ['rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia', 'institution_ids': ['https://openalex.org/I4210118449']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087637698', 'display_name': 'I. Mahmoud', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118449', 'display_name': 'Hôpital Charles-Nicolle', 'ror': 'https://ror.org/02f6ghw27', 'country_code': 'TN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210118449']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'I. Mahmoud', 'raw_affiliation_strings': ['rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia', 'institution_ids': ['https://openalex.org/I4210118449']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008429994', 'display_name': 'O. Saidane', 'orcid': 'https://orcid.org/0000-0002-7521-8018'}, 'institutions': [{'id': 'https://openalex.org/I4210118449', 'display_name': 'Hôpital Charles-Nicolle', 'ror': 'https://ror.org/02f6ghw27', 'country_code': 'TN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210118449']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'O. Saidane', 'raw_affiliation_strings': ['rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia', 'institution_ids': ['https://openalex.org/I4210118449']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108435991', 'display_name': 'H. Sahli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118449', 'display_name': 'Hôpital Charles-Nicolle', 'ror': 'https://ror.org/02f6ghw27', 'country_code': 'TN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210118449']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'H. Sahli', 'raw_affiliation_strings': ['rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia', 'institution_ids': ['https://openalex.org/I4210118449']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082394813', 'display_name': 'R. Tekaya', 'orcid': 'https://orcid.org/0000-0001-9294-9771'}, 'institutions': [{'id': 'https://openalex.org/I4210118449', 'display_name': 'Hôpital Charles-Nicolle', 'ror': 'https://ror.org/02f6ghw27', 'country_code': 'TN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210118449']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'R. Tekaya', 'raw_affiliation_strings': ['rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia', 'institution_ids': ['https://openalex.org/I4210118449']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027840398', 'display_name': 'L. Abdelmoula', 'orcid': 'https://orcid.org/0000-0003-2000-4415'}, 'institutions': [{'id': 'https://openalex.org/I4210118449', 'display_name': 'Hôpital Charles-Nicolle', 'ror': 'https://ror.org/02f6ghw27', 'country_code': 'TN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210118449']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'L. Abdelmoula', 'raw_affiliation_strings': ['rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'rhumatology department, Tunisia - Charles Nicolle Hospital, Tunis, Tunisia', 'institution_ids': ['https://openalex.org/I4210118449']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '74', 'issue': 'Suppl 2', 'first_page': '290.2', 'last_page': '290'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11092', 'display_name': 'Spondyloarthritis Studies and Treatments', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10469', 'display_name': 'Psoriasis: Treatment and Pathogenesis', 'score': 0.9778, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9786836}, {'id': 'https://openalex.org/C2780132546', 'wikidata': 'https://www.wikidata.org/wiki/Q348260', 'display_name': 'Adalimumab', 'level': 3, 'score': 0.893417}, {'id': 'https://openalex.org/C2777226972', 'wikidata': 'https://www.wikidata.org/wiki/Q415343', 'display_name': 'Etanercept', 'level': 3, 'score': 0.8283324}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.8109982}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.7642654}, {'id': 'https://openalex.org/C2777138892', 'wikidata': 'https://www.wikidata.org/wiki/Q415264', 'display_name': 'Infliximab', 'level': 3, 'score': 0.75097287}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.73554516}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.6004588}, {'id': 'https://openalex.org/C2777453003', 'wikidata': 'https://www.wikidata.org/wiki/Q4834648', 'display_name': 'BASDAI', 'level': 4, 'score': 0.5814681}, {'id': 'https://openalex.org/C198451711', 'wikidata': 'https://www.wikidata.org/wiki/Q327657', 'display_name': 'Rheumatology', 'level': 2, 'score': 0.5513798}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.4734259}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.45469254}, {'id': 'https://openalex.org/C2777402515', 'wikidata': 'https://www.wikidata.org/wiki/Q52849', 'display_name': 'Ankylosing spondylitis', 'level': 2, 'score': 0.41346908}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.38497177}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.19951156}, {'id': 'https://openalex.org/C2776260265', 'wikidata': 'https://www.wikidata.org/wiki/Q511097', 'display_name': 'Psoriatic arthritis', 'level': 3, 'score': 0.12369838}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1136/annrheumdis-2015-eular.6444', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25650217', 'display_name': 'Annals of the Rheumatic Diseases', 'issn_l': '0003-4967', 'issn': ['0003-4967', '1468-2060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032706913', 'https://openalex.org/W2613209182', 'https://openalex.org/W2529790253', 'https://openalex.org/W2363369283', 'https://openalex.org/W2254136192', 'https://openalex.org/W2168812078', 'https://openalex.org/W2162495586', 'https://openalex.org/W2075153701', 'https://openalex.org/W2052323610', 'https://openalex.org/W1525351443'], 'abstract_inverted_index': {'<h3>Background</h3>': [0], 'For': [1], 'over': [2], '10': [3], 'years,': [4], 'rheumatologists': [5], 'have': [6], 'TNF': [7, 347, 426], 'inhibitors': [8, 348, 427], 'that': [9, 413], 'revolutionized': [10], 'the': [11, 306, 327, 356, 392, 418, 435], 'treatment': [12, 31, 358, 380], 'of': [13, 29, 34, 38, 59, 117, 119, 138, 141, 155, 184, 256, 263, 265, 271, 277, 283, 285, 290, 296, 305, 329, 346, 362, 394, 434, 443], 'various': [14], 'rheumatic': [15, 35], 'and': [16, 32, 63, 69, 87, 97, 106, 127, 147, 166, 182, 186, 204, 230, 244, 252, 298, 334, 430], 'inflammatory': [17, 398], 'disorders.': [18], 'This': [19], 'biotherapy': [20, 196, 389], 'may': [21], 'in': [22, 46, 90, 238, 299, 311, 319, 370, 382, 428, 439], 'some': [23], 'cases': [24, 154, 240, 250, 254, 261, 275, 281], 'give': [25], 'intercurrent': [26], 'infections': [27], 'sources': [28], 'stopping': [30], 'reactivation': [33, 264, 328, 361], 'diseases.The': [36], 'objective': [37], 'this': [39], 'study': [40], 'is': [41, 140, 349, 352, 365], 'to': [42, 52, 323], 'evaluate': [43], 'these': [44], 'characteristics': [45], 'patients': [47, 71, 113, 371, 395], 'with': [48, 114, 396, 425], 'Spondyloarthritis': [49], '(SPA)': [50, 251, 262, 270, 295], 'compared': [51, 322], 'Rhumatoid': [53], 'Arthritis': [54], '(RA).': [55], '<h3>Methods</h3>': [56], 'Retrospective': [57], 'analysis': [58], '46': [60, 64], 'Tunisian': [61, 65], 'SPA': [62, 68, 125, 145, 156, 164, 242, 320], 'RA': [66, 70, 133, 151, 169, 247, 324, 429], 'database.': [67], 'initiating': [72], 'an': [73, 159, 405], 'anti-TNF': [74, 379], '(adalimumab': [75], '(ADA),': [76], 'etanercept': [77], '(ETA)': [78], 'or': [79, 82], 'infliximab': [80], '(INF))': [81], 'Riuximab': [83], '(RTX)': [84], 'were': [85, 171, 212, 236, 314], 'identified': [86], 'followed': [88], 'forward': [89], 'time.': [91], 'Baseline': [92], 'demographics': [93], 'included': [94], 'disease': [95], 'duration': [96, 137], 'pain': [98], 'visual': [99], 'analogical': [100], 'scale': [101], 'evaluations': [102], '(VAS),': [103], 'DAS28': [104], 'ESR': [105], 'BASDAI': [107], '<h3>Results</h3>': [108], 'The': [109, 135, 192, 341], 'analyzed': [110], 'cohort': [111], 'comprised': [112], 'average': [115, 136], 'age': [116], 'begining': [118], '25,65': [120], 'years': [121, 129, 143, 149], '(82%': [122], 'male)': [123], 'for': [124, 132, 144, 150, 163, 168, 194, 241, 246, 326, 335], 'group': [126, 146, 157, 165, 170, 243, 321, 325], '42,21': [128], '(78%': [130], 'female)': [131], 'group.': [134, 152, 359], 'evolution': [139], '10,63': [142], '12,65': [148], '11': [153], 'had': [158], 'HLA': [160], 'B27.': [161], '41%': [162], '86%': [167], 'under': [172], 'disease-modifying': [173], 'antirheumatic': [174], 'drugs': [175], '(DMARD9s)': [176], '(whose': [177], 'Methotrexate': [178, 185], '(n=9,': [179], 'SPA/35,': [180], 'RA),': [181, 219, 224], 'association': [183], 'Salazopyrine': [187], '(n=1,': [188], 'SPA/': [189, 201, 208, 217, 222, 227], '25,': [190], 'RA).': [191, 210, 233], 'reason': [193], 'starting': [195], 'was': [197, 437], 'therapy': [198], 'failure': [199], '(n=39,': [200], '5,': [202], 'RA)': [203, 229], 'adverse': [205, 317, 344], 'effects': [206, 235, 318], '(n=2,': [207], '40,': [209], 'Biotherapy': [211], 'as': [213, 385], 'follows:': [214], 'INF': [215], '(n=22,': [216], '12,': [218], 'ETA': [220], '(n=18,': [221], '14,': [223], 'ADA': [225], '(n=6,': [226], '3,': [228], 'RTX': [231], '(n=17,': [232], 'Adverse': [234], 'noted': [237, 438], '7': [239], '12': [245], 'group,': [248], '4': [249], '3': [253, 260], '(RA)': [255, 276, 282, 289, 302], 'repeatedly': [257], 'urinary': [258], 'infection,': [259, 350], 'latent': [266, 330, 363], 'tuberculosis,': [267], '1': [268, 293, 300], 'case': [269, 288, 294, 301], 'liver': [272], 'damage,': [273], '5': [274], 'allergic': [278, 336], 'reaction,': [279], '2': [280], 'infection': [284, 406], 'mild': [286], 'parts,1': [287], 'septic': [291], 'arthritis,': [292], 'uveitis': [297], 'a': [303, 410], 'tumor': [304, 433], 'ovary.': [307], 'Clinically': [308], 'significant': [309], 'differences': [310], 'baseline': [312], 'variables': [313], 'observed': [315], 'between': [316], 'tuberculosis': [331, 364], '(Log-rank': [332], 'p=0.002)': [333], 'reaction': [337], '(log-rank': [338], 'p=0.001).': [339], '<h3>Conclusions</h3>': [340], 'most': [342], 'important': [343], 'effect': [345], 'which': [351], 'significantly': [353], 'higher': [354], 'than': [355], 'non-biologic': [357], 'A': [360, 432], 'twice': [366], 'times': [367], 'more': [368], 'frequent': [369], 'using': [372], 'biotherapy.': [373], 'Paradoxical': [374], 'reactions': [375], 'do': [376], 'occur': [377], 'during': [378], 'mainly': [381], 'SPA,': [383], 'such': [384], 'acute': [386], 'uveitis.': [387], 'Although': [388], 'has': [390, 422], 'changed': [391], 'lives': [393], 'chronic': [397], 'rheumatism,': [399], 'it': [400], 'can': [401], 'bring': [402], 'not': [403], 'only': [404], 'risk,': [407], 'but': [408], 'also': [409], 'neoplastic': [411], 'risk': [412], 'requires': [414], 'rapid': [415], 'diagnosis.': [416], 'Only': [417], 'non-melanoma': [419], 'skin': [420], 'cancer': [421], 'been': [423], 'registered': [424], 'SPA.': [431], 'ovary': [436], 'our': [440], 'study.': [441], '<h3>Disclosure': [442], 'Interest</h3>': [444], 'None': [445], 'declared': [446]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2416981671', 'counts_by_year': [], 'updated_date': '2024-12-24T12:20:03.398815', 'created_date': '2016-06-24'}