Publication Information

{'id': 'https://openalex.org/W2416403108', 'doi': 'https://doi.org/10.1167/iovs.14-15969', 'title': 'Substrate Elastic Modulus Regulates the Morphology, Focal Adhesions, and α-Smooth Muscle Actin Expression of Retinal Müller Cells', 'display_name': 'Substrate Elastic Modulus Regulates the Morphology, Focal Adhesions, and α-Smooth Muscle Actin Expression of Retinal Müller Cells', 'publication_year': 2015, 'publication_date': '2015-09-16', 'ids': {'openalex': 'https://openalex.org/W2416403108', 'doi': 'https://doi.org/10.1167/iovs.14-15969', 'mag': '2416403108', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26377083'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1167/iovs.14-15969', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76304953', 'display_name': 'Investigative Ophthalmology & Visual Science', 'issn_l': '0146-0404', 'issn': ['0146-0404', '1552-5783'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321950', 'host_organization_name': 'Cadmus Press', 'host_organization_lineage': ['https://openalex.org/P4310321950'], 'host_organization_lineage_names': ['Cadmus Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1167/iovs.14-15969', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078446985', 'display_name': 'Shaochong Bu', 'orcid': 'https://orcid.org/0000-0002-9060-7361'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}, {'id': 'https://openalex.org/I4210145773', 'display_name': 'Tianjin Medical University Eye Hospital', 'ror': 'https://ror.org/04j2cfe69', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145773']}, {'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}], 'countries': ['CN', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Shao-Chong Bu', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands 3Tianjin Medical Universi', 'Tianjin Medical University Eye Centre, Tianjin Medical University, Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands 3Tianjin Medical Universi', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}, {'raw_affiliation_string': 'Tianjin Medical University Eye Centre, Tianjin Medical University, Tianjin, China', 'institution_ids': ['https://openalex.org/I4210145773', 'https://openalex.org/I5740404']}, {'raw_affiliation_string': 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077652551', 'display_name': 'Roel Kuijer', 'orcid': 'https://orcid.org/0000-0002-7637-4944'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Roel Kuijer', 'raw_affiliation_strings': ['Department of Biomedical Engineering-FB40, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands 4Department of Biomedical Engineering-FB40, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands 4Department of Biomedical Engineering-FB40, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}, {'raw_affiliation_string': 'Department of Biomedical Engineering-FB40, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030637640', 'display_name': 'Roelofje J. van der Worp', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}, {'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Roelofje J. van der Worp', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I169381384', 'https://openalex.org/I1334415907']}, {'raw_affiliation_string': 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032178500', 'display_name': 'Sander M. van Putten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Sander M. van Putten', 'raw_affiliation_strings': ['Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands', 'W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands 5Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands 5Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}, {'raw_affiliation_string': 'Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066234673', 'display_name': 'Olaf Y. Wouters', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Olaf Wouters', 'raw_affiliation_strings': ['Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands', 'W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands 5Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands 5Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}, {'raw_affiliation_string': 'Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100409015', 'display_name': 'Xiaorong Li', 'orcid': 'https://orcid.org/0000-0003-0641-2797'}, 'institutions': [{'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}, {'id': 'https://openalex.org/I4210145773', 'display_name': 'Tianjin Medical University Eye Hospital', 'ror': 'https://ror.org/04j2cfe69', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145773']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Rong Li', 'raw_affiliation_strings': ['Tianjin Medical University Eye Centre, Tianjin Medical University, Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'Tianjin Medical University Eye Centre, Tianjin Medical University, Tianjin, China', 'institution_ids': ['https://openalex.org/I5740404', 'https://openalex.org/I4210145773']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110257623', 'display_name': 'Johanna M. M. Hooymans', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}, {'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Johanna M. M. Hooymans', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I169381384', 'https://openalex.org/I1334415907']}, {'raw_affiliation_string': 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I169381384', 'https://openalex.org/I1334415907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085645592', 'display_name': 'Leonoor I. Los', 'orcid': 'https://orcid.org/0000-0002-5922-6296'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Leonoor I. Los', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}, {'raw_affiliation_string': 'Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I169381384', 'https://openalex.org/I1334415907']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5085645592'], 'corresponding_institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384'], 'apc_list': {'value': 1850, 'currency': 'USD', 'value_usd': 1850, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.297, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.713858, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '56', 'issue': '10', 'first_page': '5974', 'last_page': '5974'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11377', 'display_name': 'Retinal and Macular Surgery', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stress-fiber', 'display_name': 'Stress fiber', 'score': 0.5143415}], 'concepts': [{'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.7378439}, {'id': 'https://openalex.org/C151166631', 'wikidata': 'https://www.wikidata.org/wiki/Q904514', 'display_name': 'Focal adhesion', 'level': 3, 'score': 0.6622815}, {'id': 'https://openalex.org/C2781099445', 'wikidata': 'https://www.wikidata.org/wiki/Q4121060', 'display_name': 'Stress fiber', 'level': 4, 'score': 0.5143415}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48890892}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45020312}, {'id': 'https://openalex.org/C2780827179', 'wikidata': 'https://www.wikidata.org/wiki/Q422001', 'display_name': 'Retinal', 'level': 2, 'score': 0.41742107}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.39809427}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.3244438}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.32391644}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23121274}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.06710747}], 'mesh': [{'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D055119', 'descriptor_name': 'Elastic Modulus', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D063928', 'descriptor_name': 'Ependymoglial Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D022001', 'descriptor_name': 'Focal Adhesions', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018929', 'descriptor_name': 'Cell Culture Techniques', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D018929', 'descriptor_name': 'Cell Culture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055119', 'descriptor_name': 'Elastic Modulus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063928', 'descriptor_name': 'Ependymoglial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D063928', 'descriptor_name': 'Ependymoglial Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D063928', 'descriptor_name': 'Ependymoglial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022001', 'descriptor_name': 'Focal Adhesions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1167/iovs.14-15969', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76304953', 'display_name': 'Investigative Ophthalmology & Visual Science', 'issn_l': '0146-0404', 'issn': ['0146-0404', '1552-5783'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321950', 'host_organization_name': 'Cadmus Press', 'host_organization_lineage': ['https://openalex.org/P4310321950'], 'host_organization_lineage_names': ['Cadmus Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.rug.nl/ws/files/58262317/i1552_5783_56_10_5974.pdf', 'pdf_url': 'https://pure.rug.nl/ws/files/58262317/i1552_5783_56_10_5974.pdf', 'source': {'id': 'https://openalex.org/S4306400420', 'display_name': 'University of Groningen research database (University of Groningen / Centre for Information Technology)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I169381384', 'host_organization_name': 'University of Groningen', 'host_organization_lineage': ['https://openalex.org/I169381384'], 'host_organization_lineage_names': ['University of Groningen'], 'type': 'repository'}, 'license': 'public-domain', 'license_id': 'https://openalex.org/licenses/public-domain', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://research.rug.nl/en/publications/74aa70c2-cbb8-4695-a6eb-aafae5f967a8', 'pdf_url': 'https://research.rug.nl/files/58262317/i1552_5783_56_10_5974.pdf', 'source': {'id': 'https://openalex.org/S4306401843', 'display_name': 'Data Archiving and Networked Services (DANS)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1322597698', 'host_organization_name': 'Royal Netherlands Academy of Arts and Sciences', 'host_organization_lineage': ['https://openalex.org/I1322597698'], 'host_organization_lineage_names': ['Royal Netherlands Academy of Arts and Sciences'], 'type': 'repository'}, 'license': 'public-domain', 'license_id': 'https://openalex.org/licenses/public-domain', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26377083', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1167/iovs.14-15969', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76304953', 'display_name': 'Investigative Ophthalmology & Visual Science', 'issn_l': '0146-0404', 'issn': ['0146-0404', '1552-5783'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321950', 'host_organization_name': 'Cadmus Press', 'host_organization_lineage': ['https://openalex.org/P4310321950'], 'host_organization_lineage_names': ['Cadmus Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1481230894', 'https://openalex.org/W1506658790', 'https://openalex.org/W1549335203', 'https://openalex.org/W1576556090', 'https://openalex.org/W1909876475', 'https://openalex.org/W1915110676', 'https://openalex.org/W1962348298', 'https://openalex.org/W1964106556', 'https://openalex.org/W1973089587', 'https://openalex.org/W1973348468', 'https://openalex.org/W19734096', 'https://openalex.org/W1974170815', 'https://openalex.org/W1974797581', 'https://openalex.org/W1976368026', 'https://openalex.org/W1977341002', 'https://openalex.org/W1982130586', 'https://openalex.org/W1988306902', 'https://openalex.org/W1993006648', 'https://openalex.org/W1995528629', 'https://openalex.org/W1995609621', 'https://openalex.org/W1996738380', 'https://openalex.org/W1997875633', 'https://openalex.org/W2002582091', 'https://openalex.org/W2010447678', 'https://openalex.org/W2018358706', 'https://openalex.org/W2041219345', 'https://openalex.org/W2041592617', 'https://openalex.org/W2046697579', 'https://openalex.org/W2051696368', 'https://openalex.org/W2054635074', 'https://openalex.org/W2061997841', 'https://openalex.org/W2064761442', 'https://openalex.org/W2065439507', 'https://openalex.org/W2067192388', 'https://openalex.org/W2068092779', 'https://openalex.org/W2068743315', 'https://openalex.org/W2070538167', 'https://openalex.org/W2077997778', 'https://openalex.org/W2080629835', 'https://openalex.org/W2083553234', 'https://openalex.org/W2084527892', 'https://openalex.org/W2090565792', 'https://openalex.org/W2095301611', 'https://openalex.org/W2116317468', 'https://openalex.org/W2121416223', 'https://openalex.org/W2122988433', 'https://openalex.org/W2123676808', 'https://openalex.org/W2126486146', 'https://openalex.org/W2141075109', 'https://openalex.org/W2148328620', 'https://openalex.org/W2149873896', 'https://openalex.org/W2163599338', 'https://openalex.org/W2165690068', 'https://openalex.org/W2168111786', 'https://openalex.org/W34603460'], 'related_works': ['https://openalex.org/W4256051592', 'https://openalex.org/W4255612473', 'https://openalex.org/W4251702731', 'https://openalex.org/W4247113538', 'https://openalex.org/W4243357640', 'https://openalex.org/W4236967869', 'https://openalex.org/W4236500874', 'https://openalex.org/W4230807376', 'https://openalex.org/W2007685483', 'https://openalex.org/W1996016298'], 'abstract_inverted_index': {'Purpose:': [0], 'The': [1, 123], 'stiffness': [2], 'of': [3, 41, 103, 175, 192, 203, 211, 236], 'the': [4, 39, 42, 99, 193, 199, 218, 224, 231, 234], 'extracellular': [5, 43], 'matrix': [6, 65, 195], 'has': [7], 'been': [8, 24], 'shown': [9, 25], 'to': [10, 26, 48, 64, 90, 184, 197], 'regulate': [11], 'cell': [12, 57, 73, 148, 238], 'adhesion,': [13, 97], 'migration,': [14], 'and': [15, 59, 98, 101, 131, 153, 164, 166, 201, 223, 243], 'transdifferentiation': [16], 'in': [17, 32, 51, 62, 147, 207, 213, 244], 'fibrotic': [18, 33, 208, 227], 'processes.': [19], 'Retinal': [20], 'Müller': [21, 56, 72, 159, 205], 'cells': [22, 138, 160, 206], 'have': [23], 'be': [27], 'mechanosensitive;': [28], 'they': [29], 'are': [30], 'involved': [31], 'vitreoretinal': [34], 'diseases.': [35], 'Since': [36], 'fibrosis': [37], 'increases': [38], 'rigidity': [40], 'matrix,': [44], 'our': [45], 'aim': [46], 'was': [47, 76], 'develop': [49], 'an': [50, 172, 212], 'vitro': [52, 214], 'model': [53, 215], 'for': [54, 116], 'studying': [55], 'morphology': [58, 102, 200], 'differentiation': [60], 'state': [61], 'relation': [63], 'stiffness.': [66], 'Methods:': [67], 'A': [68], 'spontaneously': [69], 'immortalized': [70], 'human': [71], 'line': [74], '(MIO-M1)': [75], 'cultured': [77, 139, 167], 'on': [78, 140, 168, 187], 'type': [79], 'I': [80], 'collagen–coated': [81], 'polyacrylamide': [82], 'gels': [83], 'with': [84, 162, 240], "Young's": [85], 'moduli': [86], 'ranging': [87], 'from': [88], '2': [89], '92': [91], 'kPa.': [92], 'Cell': [93], 'surface': [94, 149], 'area,': [95, 150], 'focal': [96, 155], 'expression': [100], 'α-smooth': [104, 176], 'muscle': [105, 177], 'actin': [106, 178], 'induced': [107], 'by': [108, 121, 127], 'transforming': [109], 'growth': [110], 'factor': [111], 'β': [112], '(TGF-β': [113], '[10': [114], 'ng/mL': [115], '48': [117], 'hours])': [118], 'were': [119, 125], 'analyzed': [120], 'immunocytology.': [122], 'images': [124], 'documented': [126], 'using': [128], 'fluorescence': [129], 'microscopy': [130], 'confocal': [132], 'scanning': [133], 'laser': [134], 'microscopy.': [135], 'Results:': [136], 'MIO-M1': [137], 'stiff': [141, 169], 'substrates': [142, 170], 'exhibited': [143], 'a': [144], 'significant': [145], 'increase': [146], 'stress': [151, 180], 'fiber,': [152], 'mature': [154], 'adhesion': [156], 'formation.': [157], 'Furthermore,': [158], 'treated': [161], 'TGF-β1': [163], 'TGF-β2': [165], 'showed': [171], 'increased': [173], 'incorporation': [174], 'into': [179], 'fibers': [181], 'when': [182], 'compared': [183], 'those': [185], 'grown': [186], 'soft': [188], 'surfaces.': [189], 'Conclusions:': [190], 'Compliance': [191], 'surrounding': [194], 'seems': [196], 'influence': [198], 'contraction': [202], 'retinal': [204, 221, 226], 'conditions.': [209], 'Development': [210], 'simulating': [216], 'both': [217], 'normally': [219], 'compliant': [220], 'tissue': [222, 228], 'rigid': [225, 241], 'helps': [229], 'fill': [230], 'gap': [232], 'between': [233], 'results': [235], 'petri-dish': [237], 'culture': [239], 'surfaces': [242], 'vivo': [245], 'findings.': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2416403108', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-08T20:46:19.656557', 'created_date': '2016-06-24'}