Title: Vincristine effect on methotrexate cerebrospinal fluid concentration.
Abstract: A 67-year-old man with malignant lymphoma, nodular, poorly differentiated lymphocytic type, developed meningeal lymphomatosis. Repeated high-dose methotrexate-citrovorum factor treatment (1 g/m2 in 24 hours) rendered the patient free of disease. The administration of vincristine at 23 hours consistently increased the concentration of methotrexate in the cerebrospinal fluid 2.5-fold above baseline values.
Publication Year: 1979
Publication Date: 1979-01-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 8
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