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[23], 'effect': [24], 'の増強が観察された.': [25], 'そこで,': [26], 'リポソーム添加': [27], 'medium': [28], '中で培養したKU-2細胞を電顕下に観察すると,': [29], '細胞質内に,': [30], '多重層構造を呈するリポソームが認められ,': [31], '培養細胞内へのリポソームの取り込みが証明された.ヌードマウス可移植性ヒト睾丸腫瘍': [32], '(KUNU-1)': [33], 'に対する抗腫瘍効果を,': [34], '5mgの': [35], 'および,': [37], 'リポソーム封入': [38], 'にて,': [40], '比較検討すると,': [41], '腹腔内投与5日後の腫瘍の': [42], 'size': [43], 'は,': [44], '群が91±8%に対し,': [46], 'リポソーム封入群は76±14%と,': [47], 'リポソーム封入群により強い腫瘍増殖抑制を認めた.': [48], 'しかしながら,': [49], 'この時の,': [50], 'の組織内濃度を測定すると,': [52], 'リポソーム封入群で,': [53], '肝,': [54], '脾に約3~6倍の薬剤濃度を認めるが,': [55], '腫瘍内濃度では,': [56], '両者に差を認めなかつた.': [57], 'したがつて,': [58], 'この治療効果増強は,': [59], 'のリポソーム封入にともなう徐放性によると考えられた.': [61]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2415496605', 'counts_by_year': [], 'updated_date': '2024-08-15T14:25:40.516056', 'created_date': '2016-06-24'}