Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2414340276', 'doi': 'https://doi.org/10.1152/ajprenal.1991.260.1.f46', 'title': 'Mechanisms of rapid desensitization to arginine vasopressin in vascular smooth muscle cells', 'display_name': 'Mechanisms of rapid desensitization to arginine vasopressin in vascular smooth muscle cells', 'publication_year': 1991, 'publication_date': '1991-01-01', 'ids': {'openalex': 'https://openalex.org/W2414340276', 'doi': 'https://doi.org/10.1152/ajprenal.1991.260.1.f46', 'mag': '2414340276', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1825152'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajprenal.1991.260.1.f46', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200780590', 'display_name': 'AJP Renal Physiology', 'issn_l': '1522-1466', 'issn': ['1522-1466', '1931-857X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003638045', 'display_name': 'Carlos Caramelo', 'orcid': 'https://orcid.org/0000-0002-1928-5582'}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'C. Caramelo', 'raw_affiliation_strings': ['Department of Medicine, University of Colorado School of Medicine,Denver 80262.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Colorado School of Medicine,Denver 80262.', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063039957', 'display_name': 'Pei‐San Tsai', 'orcid': 'https://orcid.org/0000-0002-8650-647X'}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P. Tsai', 'raw_affiliation_strings': ['Department of Medicine, University of Colorado School of Medicine,Denver 80262.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Colorado School of Medicine,Denver 80262.', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014484265', 'display_name': 'Koji Okada', 'orcid': 'https://orcid.org/0000-0002-4317-8808'}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K. Okada', 'raw_affiliation_strings': ['Department of Medicine, University of Colorado School of Medicine,Denver 80262.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Colorado School of Medicine,Denver 80262.', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113521295', 'display_name': 'Verena Briner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'V. A. Briner', 'raw_affiliation_strings': ['Department of Medicine, University of Colorado School of Medicine,Denver 80262.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Colorado School of Medicine,Denver 80262.', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108449499', 'display_name': 'Robert W. Schrier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R. W. Schrier', 'raw_affiliation_strings': ['Department of Medicine, University of Colorado School of Medicine,Denver 80262.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Colorado School of Medicine,Denver 80262.', 'institution_ids': ['https://openalex.org/I921990950']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.79, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.747577, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '260', 'issue': '1', 'first_page': 'F46', 'last_page': 'F52'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11541', 'display_name': 'Neuroendocrine regulation and behavior', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11541', 'display_name': 'Neuroendocrine regulation and behavior', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, {'id': 'https://openalex.org/T11967', 'display_name': 'Electrolyte and hormonal disorders', 'score': 0.933, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homologous-desensitization', 'display_name': 'Homologous desensitization', 'score': 0.9435607}, {'id': 'https://openalex.org/keywords/internalization', 'display_name': 'Internalization', 'score': 0.61822057}], 'concepts': [{'id': 'https://openalex.org/C92759361', 'wikidata': 'https://www.wikidata.org/wiki/Q5891436', 'display_name': 'Homologous desensitization', 'level': 4, 'score': 0.9435607}, {'id': 'https://openalex.org/C2779779143', 'wikidata': 'https://www.wikidata.org/wiki/Q3493547', 'display_name': 'Desensitization (medicine)', 'level': 3, 'score': 0.9219694}, {'id': 'https://openalex.org/C2776370428', 'wikidata': 'https://www.wikidata.org/wiki/Q21124841', 'display_name': 'Vasopressin', 'level': 2, 'score': 0.8118607}, {'id': 'https://openalex.org/C139770010', 'wikidata': 'https://www.wikidata.org/wiki/Q1339807', 'display_name': 'Internalization', 'level': 3, 'score': 0.61822057}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5837909}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5582134}, {'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.52527225}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.47983074}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.47564456}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45372015}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.4155396}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34796542}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.2500607}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19274896}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.156961}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.0683915}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001127', 'descriptor_name': 'Arginine Vasopressin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004342', 'descriptor_name': 'Drug Hypersensitivity', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001127', 'descriptor_name': 'Arginine Vasopressin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001127', 'descriptor_name': 'Arginine Vasopressin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004342', 'descriptor_name': 'Drug Hypersensitivity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037342', 'descriptor_name': 'Pertussis Toxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011945', 'descriptor_name': 'Receptors, Angiotensin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011945', 'descriptor_name': 'Receptors, Angiotensin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011945', 'descriptor_name': 'Receptors, Angiotensin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017483', 'descriptor_name': 'Receptors, Vasopressin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010566', 'descriptor_name': 'Virulence Factors, Bordetella', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010566', 'descriptor_name': 'Virulence Factors, Bordetella', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajprenal.1991.260.1.f46', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200780590', 'display_name': 'AJP Renal Physiology', 'issn_l': '1522-1466', 'issn': ['1522-1466', '1931-857X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1825152', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W48708315', 'https://openalex.org/W4243031069', 'https://openalex.org/W2561950586', 'https://openalex.org/W2429511732', 'https://openalex.org/W2414340276', 'https://openalex.org/W2405844234', 'https://openalex.org/W2111847843', 'https://openalex.org/W2034551670', 'https://openalex.org/W2026999737', 'https://openalex.org/W2008054558'], 'abstract_inverted_index': {'This': [0], 'study': [1], 'characterized': [2], 'the': [3, 27, 37, 70, 91, 127, 137, 155, 161, 181, 184, 189], 'rapid': [4], 'desensitization': [5, 38, 43, 56, 128, 138, 190], 'induced': [6], 'by': [7, 78], 'arginine': [8], 'vasopressin': [9], '(AVP)': [10], 'in': [11, 17, 24, 50, 69, 118, 176], 'vascular': [12], 'smooth': [13], 'muscle': [14], 'cells': [15], '(VSMC)': [16], 'culture.': [18], 'The': [19, 55], 'Ca2+': [20, 156], 'mobilization': [21, 157], 'response': [22, 158], 'and,': [23], 'some': [25, 177], 'experiments,': [26], 'intracellular': [28, 163], 'pH': [29], 'changes': [30], 'were': [31], 'used': [32], 'as': [33], 'a': [34, 66, 115, 168], 'probe': [35], 'for': [36, 136], 'phenomenon.': [39, 129], 'In': [40], 'VSMC,': [41], 'AVP': [42, 119, 185], 'was': [44, 57, 65, 114], 'homologous,': [45], 'concentration': [46], 'dependent,': [47], 'and': [48, 188], 'occurred': [49, 143], 'less': [51], 'than': [52, 86], '30': [53], 's.': [54], 'complete': [58, 75], 'with': [59, 98, 149], '10(-7)': [60], 'M': [61], 'AVP.': [62], 'Receptor': [63, 130], 'occupancy': [64], 'critical': [67], 'factor': [68], 'maintenance': [71], 'of': [72, 90, 183], 'desensitization,': [73, 120], 'since': [74, 140], 'hormone': [76, 96], 'washing': [77, 97], 'acid': [79], 'glycine': [80], 'buffer': [81], 'produced': [82], 'an': [83], 'earlier': [84], '(less': [85], '5': [87], 'min)': [88], 'recovery': [89], 'cell': [92], 'response,': [93], 'whereas': [94], 'partial': [95], 'saline': [99], '(pH': [100], '7.4)': [101], 'required': [102], '15': [103], 'min': [104], 'to': [105], 'produce': [106], 'any': [107], 'significant': [108, 116], 'recovery.': [109], 'Protein': [110], 'kinase': [111, 123], 'C': [112, 124], 'activation': [113], 'mechanism': [117], 'because': [121], 'protein': [122, 172], 'downregulation': [125], 'inhibited': [126], 'internalization': [131], 'was,': [132], 'however,': [133], 'not': [134, 153, 179], 'important': [135], 'phenomenon,': [139], 'it': [141], 'still': [142], 'at': [144], '4': [145], 'degrees': [146], 'C.': [147], 'Treatment': [148], 'pertussis': [150], 'toxin': [151], 'did': [152], 'affect': [154], 'but': [159, 178], 'decreased': [160], 'AVP-mediated': [162], 'alkalinization,': [164], 'therefore': [165], 'suggesting': [166], 'that': [167], 'Gi': [169], 'or': [170], 'Go': [171], 'may': [173], 'be': [174], 'involved': [175], 'all': [180], 'aspects': [182], 'signal': [186], 'transduction': [187], 'phenomena.': [191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2414340276', 'counts_by_year': [{'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T05:43:07.088704', 'created_date': '2016-06-24'}