Title: [The significance of the mu- and delta-opiate receptors in realizing enkephalin action on the course of hypoxic hypoxia].
Abstract: New enkephalins analogues have been synthesized. They are characterized by linear, cyclic and branched peptide chain. A relationship has been established between antihypoxic activity of opioid peptides an their interaction with opiate receptors. Compounds efficiently interacting with mu-receptors irrespective of delta-receptors affinity, promote longer survival of mice in hypoxia. The antihypoxic effect of opioids is proportional to their specificity to mu-receptors.
Publication Year: 1992
Publication Date: 1992-11-01
Language: en
Type: article
Indexed In: ['pubmed']
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