Title: The effect of perphenazine treatment during the organogenesis in rats.
Abstract: The teratogenic effect of perphenazine was studied in closed-bred Wistar rats. Rats were given the substance orally continuously on days 7 to 14 of pregnancy, or as a single dose on one of days 9-15. The doses were considerably higher than the specific neuroleptic doses of perphenazine (20-150 mg/kg). The fetal mortality and malformation rates were significantly higher in the perphenazine-treated groups than in the controls. The results were compared with the earlier results of methophenazine treatment. Perphenazine was found to be more toxic for rat embryos than methophenazine.
Publication Year: 1976
Publication Date: 1976-01-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 1
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