Title: P2Y receptors: biological advances and therapeutic opportunities.
Abstract: The P2 family of membrane-bound receptors is activated by naturally occurring nucleotides. When activated, these widely distributed receptors elicit cellular signaling which mediate multiple tissue-specific effects throughout the body. P2X receptors are ligand-gated ionotropic channels, while P2Y receptors belong to the superfamily of metabotropic G protein-coupled receptors. To date, there are six human cloned and functionally characterized subtypes of the P2Y family: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11 and P2Y12. There exists enough agonist specificity between receptor subtypes to allow functional identification of newly found putative receptors. There are few specific antagonists of the P2Y receptors.
Publication Year: 2001
Publication Date: 2001-09-01
Language: en
Type: article
Indexed In: ['pubmed']
Access and Citation
Cited By Count: 25
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