Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2412293344', 'doi': 'https://doi.org/10.4238/2015.december.7.4', 'title': 'Changes of circulating CD4+CD25+CD127low regulatory T cells in patients with acute coronary syndrome and its significance', 'display_name': 'Changes of circulating CD4+CD25+CD127low regulatory T cells in patients with acute coronary syndrome and its significance', 'publication_year': 2015, 'publication_date': '2015-01-01', 'ids': {'openalex': 'https://openalex.org/W2412293344', 'doi': 'https://doi.org/10.4238/2015.december.7.4', 'mag': '2412293344', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26662384'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4238/2015.december.7.4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206553565', 'display_name': 'Genetics and Molecular Research', 'issn_l': '1676-5680', 'issn': ['1676-5680'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4322633623', 'host_organization_name': 'Research Foundation of Ribeirão Preto', 'host_organization_lineage': ['https://openalex.org/P4322633623'], 'host_organization_lineage_names': ['Research Foundation of Ribeirão Preto'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.4238/2015.december.7.4', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100658243', 'display_name': 'Min Liu', 'orcid': 'https://orcid.org/0000-0002-5059-3743'}, 'institutions': [{'id': 'https://openalex.org/I4210136596', 'display_name': 'First Affiliated Hospital of Anhui Medical University', 'ror': 'https://ror.org/03t1yn780', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136596']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'M. Liu', 'raw_affiliation_strings': ['Cardiovascular Department, The First Affiliated Hospital of Anhui Medical University, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Department, The First Affiliated Hospital of Anhui Medical University, Anhui, China', 'institution_ids': ['https://openalex.org/I4210136596', 'https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086110755', 'display_name': 'Lihua Xu', 'orcid': 'https://orcid.org/0000-0002-3437-1286'}, 'institutions': [{'id': 'https://openalex.org/I4210149412', 'display_name': 'Second Hospital of Anhui Medical University', 'ror': 'https://ror.org/047aw1y82', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210149412']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'L.-J. Xu', 'raw_affiliation_strings': ['Cardiovascular Department, The Second Affiliated Hospital of Anhui Medical University, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Department, The Second Affiliated Hospital of Anhui Medical University, Anhui, China', 'institution_ids': ['https://openalex.org/I4210149412', 'https://openalex.org/I197869895']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004820665', 'display_name': 'Jiatian Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210149412', 'display_name': 'Second Hospital of Anhui Medical University', 'ror': 'https://ror.org/047aw1y82', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210149412']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'J.-X. Wu', 'raw_affiliation_strings': ['Cardiovascular Department, The Second Affiliated Hospital of Anhui Medical University, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Department, The Second Affiliated Hospital of Anhui Medical University, Anhui, China', 'institution_ids': ['https://openalex.org/I4210149412', 'https://openalex.org/I197869895']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.3, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.654946, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '14', 'issue': '4', 'first_page': '15930', 'last_page': '15936'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12955', 'display_name': 'Immunological Mechanisms in Atherosclerosis Development', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12955', 'display_name': 'Immunological Mechanisms in Atherosclerosis Development', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'Regulatory T Cell Development and Function', 'score': 0.9731, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Natural Killer Cells in Immunity', 'score': 0.9593, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/interleukin-7-receptor', 'display_name': 'Interleukin-7 receptor', 'score': 0.8016914}, {'id': 'https://openalex.org/keywords/cd4+cd25+', 'display_name': 'CD4+CD25+', 'score': 0.533512}, {'id': 'https://openalex.org/keywords/regulatory-t-cells', 'display_name': 'Regulatory T Cells', 'score': 0.530237}, {'id': 'https://openalex.org/keywords/unstable-angina', 'display_name': 'Unstable angina', 'score': 0.4899227}, {'id': 'https://openalex.org/keywords/concordance', 'display_name': 'Concordance', 'score': 0.4192116}], 'concepts': [{'id': 'https://openalex.org/C123982805', 'wikidata': 'https://www.wikidata.org/wiki/Q6046964', 'display_name': 'Interleukin-7 receptor', 'level': 5, 'score': 0.8016914}, {'id': 'https://openalex.org/C79484868', 'wikidata': 'https://www.wikidata.org/wiki/Q5971673', 'display_name': 'IL-2 receptor', 'level': 4, 'score': 0.7788793}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.67690986}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6306418}, {'id': 'https://openalex.org/C2777698277', 'wikidata': 'https://www.wikidata.org/wiki/Q266018', 'display_name': 'Acute coronary syndrome', 'level': 3, 'score': 0.59110814}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.5674758}, {'id': 'https://openalex.org/C207886595', 'wikidata': 'https://www.wikidata.org/wiki/Q1456138', 'display_name': 'Pathological', 'level': 2, 'score': 0.5346509}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.5224287}, {'id': 'https://openalex.org/C2777785093', 'wikidata': 'https://www.wikidata.org/wiki/Q2032041', 'display_name': 'Unstable angina', 'level': 3, 'score': 0.4899227}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.48300397}, {'id': 'https://openalex.org/C3017910909', 'wikidata': 'https://www.wikidata.org/wiki/Q618363', 'display_name': 'Peripheral blood', 'level': 2, 'score': 0.4742795}, {'id': 'https://openalex.org/C46762472', 'wikidata': 'https://www.wikidata.org/wiki/Q178648', 'display_name': 'Peripheral', 'level': 2, 'score': 0.42929947}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4282439}, {'id': 'https://openalex.org/C160798450', 'wikidata': 'https://www.wikidata.org/wiki/Q4230870', 'display_name': 'Concordance', 'level': 2, 'score': 0.4192116}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.39955467}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.3888517}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.38069734}, {'id': 'https://openalex.org/C3018906752', 'wikidata': 'https://www.wikidata.org/wiki/Q844935', 'display_name': 'Coronary heart disease', 'level': 2, 'score': 0.10745102}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.07430524}], 'mesh': [{'descriptor_ui': 'D054058', 'descriptor_name': 'Acute Coronary Syndrome', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D054058', 'descriptor_name': 'Acute Coronary Syndrome', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D054058', 'descriptor_name': 'Acute Coronary Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002097', 'descriptor_name': 'C-Reactive Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016130', 'descriptor_name': 'Immunophenotyping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053645', 'descriptor_name': 'Interleukin-2 Receptor alpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053645', 'descriptor_name': 'Interleukin-2 Receptor alpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053699', 'descriptor_name': 'Interleukin-7 Receptor alpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053699', 'descriptor_name': 'Interleukin-7 Receptor alpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007958', 'descriptor_name': 'Leukocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018655', 'descriptor_name': 'Lymphocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4238/2015.december.7.4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206553565', 'display_name': 'Genetics and Molecular Research', 'issn_l': '1676-5680', 'issn': ['1676-5680'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4322633623', 'host_organization_name': 'Research Foundation of Ribeirão Preto', 'host_organization_lineage': ['https://openalex.org/P4322633623'], 'host_organization_lineage_names': ['Research Foundation of Ribeirão Preto'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26662384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4238/2015.december.7.4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206553565', 'display_name': 'Genetics and Molecular Research', 'issn_l': '1676-5680', 'issn': ['1676-5680'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4322633623', 'host_organization_name': 'Research Foundation of Ribeirão Preto', 'host_organization_lineage': ['https://openalex.org/P4322633623'], 'host_organization_lineage_names': ['Research Foundation of Ribeirão Preto'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 9, 'referenced_works': ['https://openalex.org/W1970017301', 'https://openalex.org/W1984338451', 'https://openalex.org/W2050671947', 'https://openalex.org/W2140694954', 'https://openalex.org/W2146924282', 'https://openalex.org/W2164528568', 'https://openalex.org/W2322380801', 'https://openalex.org/W2382887841', 'https://openalex.org/W2949035540'], 'related_works': ['https://openalex.org/W3031438654', 'https://openalex.org/W3028646680', 'https://openalex.org/W2978025240', 'https://openalex.org/W2416707802', 'https://openalex.org/W2394384891', 'https://openalex.org/W2387346711', 'https://openalex.org/W2381905385', 'https://openalex.org/W2349208158', 'https://openalex.org/W2069586323', 'https://openalex.org/W1816675776'], 'abstract_inverted_index': {'The': [0], 'aim': [1], 'of': [2, 10, 69, 85, 94, 160, 211, 214, 221, 229, 231, 247, 251], 'this': [3], 'study': [4], 'was': [5, 33, 112, 171], 'to': [6, 101, 167], 'investigate': [7], 'the': [8, 67, 82, 106, 135, 141, 150, 157, 175, 185, 209, 212, 218, 227, 232, 243, 248], 'changes': [9], 'circulating': [11], 'CD4': [12, 52, 95, 102, 161, 168], '+': [13, 15, 53, 55, 96, 98, 103, 162, 164, 169], 'CD25': [14, 54, 97, 163], 'CD127': [16, 56, 99, 165], 'low': [17, 57, 100, 166], 'regulatory': [18], 'T': [19], 'cells': [20, 170, 216], '(Treg)': [21], 'in': [22, 81, 105, 118, 140, 149, 217, 242], 'patients': [23, 222], 'with': [24, 174, 223], 'acute': [25], 'coronary': [26], 'syndrome': [27], '(ACS)': [28], 'and': [29, 47, 66, 74, 123, 137, 178, 184, 191, 194, 236, 245], 'its': [30], 'significance.The': [31], 'experiment': [32], 'divided': [34], 'into': [35], 'three': [36], 'groups:': [37], 'ACS': [38, 107, 142, 224], '(48': [39], 'patients),': [40, 46], 'stable': [41], 'angina': [42], 'pectoris': [43], '(SAP)': [44], '(24': [45, 50], 'normal': [48], 'controls': [49], 'subjects).The': [51], 'Treg': [58, 215], 'cell': [59, 104], 'counts': [60, 180], 'were': [61, 79, 89, 144, 189], 'tested': [62], 'by': [63, 181], 'flow': [64], 'cytometry,': [65], 'levels': [68, 139], 'high-sensitivity': [70], 'C-reactive': [71], 'protein': [72], '(hs-CRP)': [73], 'peripheral': [75, 83, 219, 233], 'blood': [76, 84, 220], 'leukocytes': [77], '(PWBCs)': [78], 'determined': [80], 'each': [86], 'group;': [87], 'comparisons': [88], 'made': [90], 'among': [91], 'groups.The': [92], 'frequency': [93, 159, 213], 'group': [108, 143, 152], '(3.18': [109], '±': [110, 121, 126], '1.76%)': [111], 'significantly': [113, 145], 'lower': [114], 'than': [115, 147], 'those': [116, 148], 'observed': [117], 'control': [119, 151], '(5.64': [120], '1.63%)': [122], 'SAP': [124], '(5.60': [125], '1.56%)': [127], 'groups': [128], '(F': [129], '=': [130], '25.247,P': [131], '<': [132, 154, 204], '0.01),': [133], 'while': [134], 'hs-CRP': [136, 177], 'PWBC': [138, 179], 'higher': [146], '(P': [153, 203], '0.05).In': [155], 'addition,': [156], 'reduced': [158], 'negatively': [172], 'correlated': [173], 'increased': [176], 'correlation': [182], 'analysis,': [183], 'related': [186], 'coefficients': [187], '(r)': [188], '-0.518': [190], '©FUNPEC-RP': [192], 'www.funpecrp.com.brGenetics': [193], 'Molecular': [195], 'Research': [196], '14': [197], '(4):': [198], '15930-15936': [199], '(2015)': [200], '-0.311,': [201], 'respectively': [202], '0.01).These': [205], 'findings': [206], 'indicate': [207], 'that': [208], 'decrease': [210], 'might': [225, 237], 'destroy': [226], 'balance': [228], 'tolerance': [230], 'immune': [234], 'system': [235], 'activate': [238], 'inflammation,': [239], 'thus': [240], 'participating': [241], 'occurrence': [244], 'development': [246], 'pathological': [249], 'processes': [250], 'atherosclerosis.': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2412293344', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2024-09-19T18:28:30.863543', 'created_date': '2016-06-24'}