Publication Information

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'physiological': [111], 'significance': [112], 'well': [117], 'their': [119], 'possible': [120], 'involvement': [121], 'such': [123, 302], 'clinical': [124], 'symptoms': [125], 'intractable': [127], 'pain.The': [128], 'purpose': [129], 'this': [131], 'study': [132, 370], 'was': [133, 149, 196, 214, 225, 245, 283, 358, 362], 'to': [134, 156, 168, 207, 227, 273, 337, 348, 410], 'establish': [135], 'radioreceptor-assay': [137, 238], 'system': [138], 'met-enkephalin-like': [141, 241, 394], 'substance': [142, 242, 395], 'CSF.': [145], 'A': [146], 'particulate': [147], 'fraction': [148], 'prepared': [150], 'from': [151, 270, 281, 307, 326, 364, 408], 'rat': [152], 'essentially': [154], 'according': [155], 'method': [158], 'Pasternak': [160], 'used': [162, 197], 'receptor.': [165], 'order': [167], 'obtain': [169], 'most': [171], 'sensitive': [172], 'radioreceptor-assay,': [173], 'displacement': [174], 'curves': [175], 'by': [176, 285, 293, 310, 328, 379], 'met-enkephalin': [177, 205, 280, 309, 357], 'were': [178, 305, 324, 335, 344, 377, 391, 397], 'compared': [179], 'each': [181], 'other': [182], 'using': [183, 248], 'three': [184], 'kinds': [185], 'radiolabeled': [187, 200, 252], 'ligand': [188, 253], ':': [189], '3H-met-enkephalin,': [190], '3H-naloxone': [191], '3H-dihydromorphine.': [193], 'When': [194], '3H-dihydromorphine': [195, 249, 323], 'ligand,': [201], 'concentration': [203], 'required': [206], 'inhibit': [208], '50%': [209], 'specific': [211, 320], 'binding': [212, 321], '(IC50)': [213], 'lowest.': [216], 'addition': [218], '1mM': [220], 'EDTA': [221, 260], '2mM': [223, 262], 'Mg': [224], 'decrease': [228], 'further': [229], 'IC50': [231], 'enhance': [233], 'binding.': [235], 'Thus': [236], 'CSF': [244, 282, 327, 334, 361, 376], 'carried': [246], 'out': [247], 'presence': [256], '1': [258, 272], 'rnM': [259], 'Mg.': [263], 'sensitivity': [265], 'assay': [268], 'ranged': [269, 407], 'about': [271, 359], '100': [274], 'pmoles': [275, 412], 'met-enkephalin.The': [277], 'isolation': [278], 'performed': [284], 'Sephadex': [287], 'G': [288], '10': [289], 'gel': [290, 311], 'filtration': [291], 'followed': [292], 'SP-Sephadex': [295], '(H+)': [296], 'column': [297], 'chromatography.': [298, 330], 'Large': [299], 'substances': [301], 'β-endorphin': [304], 'separated': [306], 'filtration.': [312], 'Sodium': [313], 'non-specific': [315], 'inhibitor': [316], 'removed': [325], 'Five': [331], 'ml': [332, 374], 'applied': [336], 'two': [338], 'successive': [339], 'columns,': [340], 'elutes': [343], 'lyophilized': [345], 'subjected': [347], 'quantification': [349], 'radioreceptor-assay.': [352], 'overall': [354], 'recovery': [355], '60%.Human': [360], 'obtained': [363], '8': [365], 'patients': [366], 'hospitalized': [367], 'for': [368], 'neurosurgical': [369], 'therapy.': [372], 'Ten': [373], 'drawn': [378], 'lumbar': [380], 'puncture': [381], 'kept': [383], 'frozen': [384], 'at': [385], '-60°C': [386], 'until': [387], 'assayed.': 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