Title: The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain.
Abstract: Cerebrospinal fluid (CSF) transthyretin (TTR), the main CSF thyroxine (T4) carrier protein in the rat and the human is synthesized in the choroid plexus (CP). After injection of 125I-T4 in the rat, radioactive T4 accumulates first in the CP, then in the CSF and later in the brain. We have shown that competitive inhibition of T4-TTR binding sites in the CP and CSF by a flavonoid results in a decrease in the radioactivity present in the brain after i.v. injection of 125I-T4, suggesting that T4 transported to the CSF via the CP is a significant pathway for the supply of thyroid hormones to the brain.
Publication Year: 1992
Publication Date: 1992-01-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 26
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