Publication Information

{'id': 'https://openalex.org/W2412007572', 'doi': 'https://doi.org/10.1242/jeb.204.15.2699', 'title': 'Mechanisms of urea tolerance in urea-adapted populations of<i>Drosophila melanogaster</i>', 'display_name': 'Mechanisms of urea tolerance in urea-adapted populations of<i>Drosophila melanogaster</i>', 'publication_year': 2001, 'publication_date': '2001-08-01', 'ids': {'openalex': 'https://openalex.org/W2412007572', 'doi': 'https://doi.org/10.1242/jeb.204.15.2699', 'mag': '2412007572', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11533120'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1242/jeb.204.15.2699', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S20257348', 'display_name': 'Journal of Experimental Biology', 'issn_l': '0022-0949', 'issn': ['0022-0949', '1477-9145'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061199813', 'display_name': 'Regine Etienne', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142393192', 'display_name': 'College of Staten Island', 'ror': 'https://ror.org/02p179j44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I142393192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Regine Etienne', 'raw_affiliation_strings': ['Department of Biology, College of Staten Island/CUNY, 2800 Victory Boulevard, Staten Island, NY 10314, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, College of Staten Island/CUNY, 2800 Victory Boulevard, Staten Island, NY 10314, USA', 'institution_ids': ['https://openalex.org/I142393192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050914156', 'display_name': 'Kechener Fortunat', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142393192', 'display_name': 'College of Staten Island', 'ror': 'https://ror.org/02p179j44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I142393192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kechener Fortunat', 'raw_affiliation_strings': ['Department of Biology, College of Staten Island/CUNY, 2800 Victory Boulevard, Staten Island, NY 10314, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, College of Staten Island/CUNY, 2800 Victory Boulevard, Staten Island, NY 10314, USA', 'institution_ids': ['https://openalex.org/I142393192']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033384855', 'display_name': 'Valerie A. Pierce', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142393192', 'display_name': 'College of Staten Island', 'ror': 'https://ror.org/02p179j44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I142393192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Valerie Pierce', 'raw_affiliation_strings': ['Department of Biology, College of Staten Island/CUNY, 2800 Victory Boulevard, Staten Island, NY 10314, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, College of Staten Island/CUNY, 2800 Victory Boulevard, Staten Island, NY 10314, USA', 'institution_ids': ['https://openalex.org/I142393192']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.224, 'has_fulltext': False, 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.584554, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '204', 'issue': '15', 'first_page': '2699', 'last_page': '2707'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11056', 'display_name': 'Physiological and biochemical adaptations', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10174', 'display_name': 'Animal Behavior and Reproduction', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1105', 'display_name': 'Ecology, Evolution, Behavior and Systematics'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hemolymph', 'display_name': 'Hemolymph', 'score': 0.6170447}], 'concepts': [{'id': 'https://openalex.org/C2780365088', 'wikidata': 'https://www.wikidata.org/wiki/Q48318', 'display_name': 'Urea', 'level': 2, 'score': 0.9721273}, {'id': 'https://openalex.org/C100068826', 'wikidata': 'https://www.wikidata.org/wiki/Q485675', 'display_name': 'Hemolymph', 'level': 2, 'score': 0.6170447}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.5782984}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.52337277}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.47057077}, {'id': 'https://openalex.org/C10146269', 'wikidata': 'https://www.wikidata.org/wiki/Q185557', 'display_name': 'Excretion', 'level': 2, 'score': 0.47041896}, {'id': 'https://openalex.org/C140793950', 'wikidata': 'https://www.wikidata.org/wiki/Q168091', 'display_name': 'Animal science', 'level': 1, 'score': 0.4511671}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32661596}], 'mesh': [{'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000222', 'descriptor_name': 'Adaptation, Physiological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004032', 'descriptor_name': 'Diet', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004361', 'descriptor_name': 'Drug Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006458', 'descriptor_name': 'Hemolymph', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006458', 'descriptor_name': 'Hemolymph', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1242/jeb.204.15.2699', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S20257348', 'display_name': 'Journal of Experimental Biology', 'issn_l': '0022-0949', 'issn': ['0022-0949', '1477-9145'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11533120', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.49, 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1184179188', 'https://openalex.org/W1504490211', 'https://openalex.org/W153489251', 'https://openalex.org/W1563177871', 'https://openalex.org/W1584160551', 'https://openalex.org/W1878371896', 'https://openalex.org/W1879220584', 'https://openalex.org/W1940527306', 'https://openalex.org/W1963742054', 'https://openalex.org/W1964603949', 'https://openalex.org/W1983574642', 'https://openalex.org/W1985015433', 'https://openalex.org/W1986115510', 'https://openalex.org/W1988137523', 'https://openalex.org/W1990725516', 'https://openalex.org/W1992897439', 'https://openalex.org/W2016487391', 'https://openalex.org/W2017178589', 'https://openalex.org/W2028311036', 'https://openalex.org/W2036021155', 'https://openalex.org/W2042183801', 'https://openalex.org/W2050557334', 'https://openalex.org/W2055792804', 'https://openalex.org/W2061002513', 'https://openalex.org/W2073009499', 'https://openalex.org/W2079498128', 'https://openalex.org/W2084759866', 'https://openalex.org/W2087460940', 'https://openalex.org/W2104271112', 'https://openalex.org/W2109268015', 'https://openalex.org/W2120378837', 'https://openalex.org/W2124269029', 'https://openalex.org/W2138610132', 'https://openalex.org/W2144664512', 'https://openalex.org/W2147583598', 'https://openalex.org/W2159557474', 'https://openalex.org/W2179348510', 'https://openalex.org/W2183427423', 'https://openalex.org/W2313757065', 'https://openalex.org/W2346770017', 'https://openalex.org/W2399182681', 'https://openalex.org/W3143608703', 'https://openalex.org/W411566327', 'https://openalex.org/W4245549186', 'https://openalex.org/W568806491', 'https://openalex.org/W96165550', 'https://openalex.org/W972026182'], 'related_works': ['https://openalex.org/W2592794631', 'https://openalex.org/W2388960186', 'https://openalex.org/W23724372', 'https://openalex.org/W2262177935', 'https://openalex.org/W2094071155', 'https://openalex.org/W2078260086', 'https://openalex.org/W2062380464', 'https://openalex.org/W2036288686', 'https://openalex.org/W1983213408', 'https://openalex.org/W1980997809'], 'abstract_inverted_index': {'SUMMARY': [0], 'When': [1], 'behavioral': [2], 'avoidance': [3], 'cannot': [4], 'prevent': [5], 'an': [6], 'animal': [7], 'from': [8, 101, 159], 'being': [9], 'exposed': [10], 'to': [11, 42, 150, 177, 267, 270, 280], 'novel': [12], 'environmental': [13], 'toxins,': [14], 'physiological': [15], 'mechanisms': [16], 'must': [17], 'cope': [18], 'with': [19], 'the': [20, 28, 56, 72, 90, 102, 155, 182, 188, 220, 244, 255, 263, 276, 285], 'toxin': [21], 'and': [22, 44, 97, 118, 140, 153, 169, 180, 223], 'its': [23], 'effects.': [24], 'We': [25, 104, 162, 190], 'are': [26], 'investigating': [27], 'basis': [29], 'of': [30, 35, 62, 78, 85, 114, 126, 157, 184, 234, 278], 'urea': [31, 63, 87, 92, 95, 99, 107, 124, 131, 158, 164, 178, 185, 195, 206, 218, 230, 235, 260, 271, 279], 'tolerance': [32], 'in': [33, 46, 64, 89, 134, 187, 237, 246, 258, 284, 294], 'populations': [34], 'Drosophila': [36], 'melanogaster': [37], 'that': [38, 55, 251], 'have': [39, 59, 268], 'been': [40], 'selected': [41, 170, 221, 238, 264], 'survive': [43], 'develop': [45], 'food': [47, 145, 152, 179], 'containing': [48], '300mmoll−1': [49], 'urea.': [50], 'Previous': [51], 'research': [52], 'has': [53], 'demonstrated': [54], 'urea-selected': [57, 141], 'larvae': [58, 69, 142, 171, 204, 222, 239, 265], 'lower': [60], 'levels': [61, 88], 'their': [65, 127, 160, 282], 'body': [66, 259, 283], 'than': [67, 211, 219, 243], 'control': [68, 139, 168, 247], 'reared': [70, 138], 'under': [71], 'same': [73], 'conditions.': [74], 'The': [75, 232, 288], 'current': [76], 'series': [77], 'experiments': [79], 'focuses': [80], 'on': [81, 143, 172], 'three': [82], 'possible': [83], 'ways': [84], 'reducing': [86], 'body:': [91], 'metabolism,': [93], 'increased': [94], 'excretion': [96, 132], 'decreased': [98], 'uptake': [100, 165, 236, 295], 'environment.': [103], 'tested': [105], 'for': [106, 112, 122, 194, 229, 254, 291], 'metabolism': [108, 196], 'directly,': [109], 'by': [110, 120, 166, 197, 274], 'assaying': [111], 'activity': [113], 'two': [115], 'urea-metabolizing': [116], 'enzymes,': [117], 'indirectly,': [119], 'looking': [121], 'reduced': [123], 'content': [125], 'medium.': [128], 'To': [129], 'measure': [130], 'rates': [133], 'whole': [135], 'animals,': [136], 'we': [137], 'urea-containing': [144], '(urea': [146], 'food),': [147], 'switched': [148], 'them': [149, 176], 'normal': [151, 173], 'monitored': [154], 'loss': [156], 'hemolymph.': [161, 189], 'measured': [163, 256], 'rearing': [167], 'food,': [174], 'switching': [175], 'monitoring': [181], 'rate': [183, 210, 233, 245], 'appearance': [186], 'found': [191], 'no': [192], 'evidence': [193], 'either': [198], 'direct': [199], 'or': [200], 'indirect': [201], 'methods.': [202], 'Control': [203], 'excreted': [205], 'at': [207], 'a': [208, 226, 249], 'higher': [209], 'selected,': [212], 'probably': [213], 'because': [214], 'they': [215], 'contained': [216], 'more': [217], 'thus': [224], 'had': [225], 'greater': [227], 'gradient': [228], 'loss.': [231], 'was': [240], '2mmoll−1h−1': [241], 'slower': [242], 'larvae,': [248], 'difference': [250], 'could': [252], 'account': [253], 'differences': [257], 'levels.': [261], 'Thus': [262], 'appear': [266], 'adapted': [269], 'exposure': [272], 'primarily': [273], 'decreasing': [275], 'ability': [277], 'enter': [281], 'first': [286], 'place.': [287], 'mechanism': [289], 'responsible': [290], 'this': [292], 'reduction': [293], 'is': [296], 'uncertain.': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2412007572', 'counts_by_year': [{'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T02:57:37.651025', 'created_date': '2016-06-24'}