Title: Function of DnaA Protein, the Initiator for Chromosomal DNA Replication in E.coli
Abstract: DnaA protein is an initiator for chromosomal DNA replication in E.coli. We have examined the function of the protein to answer the foollowing four questions;(1) How DnaA protein is inactivated after DNA replication for the suppression of re-initiation? (2) How DnaA protein is activated for the initiation of DNA replication? (3) Does DnaA protein have functions other than that for DNA replication? (4) Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.