Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2411805200', 'doi': 'https://doi.org/10.7534/j.issn.1009-2137.2013.02.020', 'title': '[Effects of decitabine on proliferation and apoptosis of NB4 and K562 cells].', 'display_name': '[Effects of decitabine on proliferation and apoptosis of NB4 and K562 cells].', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W2411805200', 'doi': 'https://doi.org/10.7534/j.issn.1009-2137.2013.02.020', 'mag': '2411805200', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23628032'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23628032', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024470614', 'display_name': 'Xinai Han', 'orcid': 'https://orcid.org/0000-0002-3642-330X'}, 'institutions': [{'id': 'https://openalex.org/I4210088873', 'display_name': 'Third Affiliated Hospital of Southern Medical University', 'ror': 'https://ror.org/0050r1b65', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088873']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xin-Ai Han', 'raw_affiliation_strings': ['Department of Rheumatology, Third Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Third Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.', 'institution_ids': ['https://openalex.org/I4210088873']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059384216', 'display_name': 'Huilan Zeng', 'orcid': 'https://orcid.org/0000-0001-7723-0486'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hui-Lan Zeng', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000334611', 'display_name': 'Yanping Han', 'orcid': 'https://orcid.org/0000-0002-0938-777X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yan-Ping Han', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100382884', 'display_name': 'Erwei Sun', 'orcid': 'https://orcid.org/0000-0001-5664-513X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Er-Wei Sun', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.246, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.5319, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 65, 'max': 72}, 'biblio': {'volume': '21', 'issue': '2', 'first_page': '356', 'last_page': '60'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.7973, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.7973, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.7725, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.7652, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/k562-cells', 'display_name': 'K562 cells', 'score': 0.68915874}, {'id': 'https://openalex.org/keywords/decitabine', 'display_name': 'Decitabine', 'score': 0.53918916}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.76611185}, {'id': 'https://openalex.org/C171122931', 'wikidata': 'https://www.wikidata.org/wiki/Q6324626', 'display_name': 'K562 cells', 'level': 3, 'score': 0.68915874}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.6230582}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5665966}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.5513803}, {'id': 'https://openalex.org/C2780235182', 'wikidata': 'https://www.wikidata.org/wiki/Q1181878', 'display_name': 'Decitabine', 'level': 5, 'score': 0.53918916}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.5268803}, {'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.47446424}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4453062}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.44035152}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.4340304}, {'id': 'https://openalex.org/C74864618', 'wikidata': 'https://www.wikidata.org/wiki/Q2332446', 'display_name': 'Staining', 'level': 2, 'score': 0.41398537}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33927435}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.26478294}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15742883}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.066663444}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077209', 'descriptor_name': 'Decitabine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020014', 'descriptor_name': 'K562 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23628032', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.49}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3031579642', 'https://openalex.org/W2410520497', 'https://openalex.org/W2382230817', 'https://openalex.org/W2374592133', 'https://openalex.org/W2364535361', 'https://openalex.org/W2363671651', 'https://openalex.org/W2355505869', 'https://openalex.org/W2354735832', 'https://openalex.org/W2354128257', 'https://openalex.org/W2350294409'], 'abstract_inverted_index': {'This': [0], 'study': [1], 'was': [2, 31, 52, 69, 107, 203], 'aimed': [3], 'to': [4, 71, 169], 'investigate': [5], 'the': [6, 44, 82, 128, 137, 170], 'effects': [7], 'of': [8, 15, 24, 39, 46, 84, 98, 156, 161], 'decitabine': [9], '(DAC)': [10], 'on': [11, 26], 'proliferation': [12, 22, 83], 'and': [13, 18, 28, 49, 86, 101, 110, 186, 191, 221, 228], 'apoptosis': [14, 187], 'leukemia': [16], 'NB4': [17, 27, 85, 100, 190, 220, 234], 'K562': [19, 29, 87, 102, 192, 222], 'cells.': [20, 235], 'The': [21, 57, 66, 75, 93, 153, 176], 'inhibition': [23], 'DAC': [25, 40, 79, 121, 148, 195, 208, 217], 'cells': [30, 88, 103, 193], 'detected': [32, 179], 'by': [33, 54, 63, 180], 'Trypan': [34], 'blue': [35], 'staining.': [36, 65], 'After': [37, 114], 'treatment': [38], 'at': [41, 122, 210], 'different': [42, 123], 'concentrations,': [43], 'changes': [45, 60], 'cell': [47, 58, 73, 118, 129, 138, 163, 177, 223, 226], 'cycle': [48], 'CD11b': [50, 160], 'expression': [51, 154], 'determined': [53], 'flow': [55], 'cytometry.': [56], 'morphological': [59], 'were': [61], 'observed': [62, 204], "Wright's": [64, 181], 'DNA': [67, 201], 'ladder': [68, 202], 'used': [70], 'detect': [72], 'apoptosis.': [74], 'results': [76], 'indicated': [77], 'that': [78, 216], 'significantly': [80, 134, 165], 'inhibited': [81], 'in': [89, 131, 140, 145, 167, 205], 'dose-and': [90], 'time-dependent': [91], 'manner.': [92], 'median': [94], 'inhibitory': [95], 'concentration': [96, 124], '(IC50)': [97], 'DAC-treated': [99], 'for': [104, 125, 196, 233], '72': [105, 126], 'h': [106], '0.113': [108], 'µmol/L': [109, 147, 207], '0.138': [111], 'µmol/L,': [112], 'respectively.': [113], 'treating': [115, 189], 'these': [116], 'two': [117], 'lines': [119, 164], 'with': [120, 194], 'h,': [127], 'ratio': [130, 139], 'G0/G1': [132], 'phase': [133, 142], 'increased,': [135], 'while': [136], 'S': [141], 'obviously': [143, 232], 'decreased': [144], '0.15': [146, 206], 'group': [149, 172, 209], '(P': [150, 173], '<': [151, 174], '0.05).': [152, 175], 'levels': [155], 'myeloid': [157], 'differentiation': [158, 185, 227], 'antigen': [159], 'both': [162], 'increased': [166], 'contrast': [168], 'control': [171], 'morphology': [178], 'staining': [182], 'displayed': [183], 'partial': [184], 'after': [188], '48': [197, 211], 'h.': [198, 212], 'Typical': [199], 'apoptotic': [200], 'It': [213], 'is': [214], 'concluded': [215], 'can': [218], 'inhibit': [219], 'proliferation,': [224], 'induce': [225], 'apoptosis,': [229], 'but': [230], 'more': [231]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2411805200', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-07T19:21:06.172342', 'created_date': '2016-06-24'}