Publication Information

{'id': 'https://openalex.org/W2411389177', 'doi': 'https://doi.org/10.1074/mcp.m116.058313', 'title': 'Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling', 'display_name': 'Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling', 'publication_year': 2016, 'publication_date': '2016-06-04', 'ids': {'openalex': 'https://openalex.org/W2411389177', 'doi': 'https://doi.org/10.1074/mcp.m116.058313', 'mag': '2411389177', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27259358', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4974343'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m116.058313', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/8/2671.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.mcponline.org/content/mcprot/15/8/2671.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048396769', 'display_name': 'Emily S. Humphrey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}, {'id': 'https://openalex.org/I4210087110', 'display_name': "St Vincent's Hospital", 'ror': 'https://ror.org/001kjn539', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087110', 'https://openalex.org/I4210098850']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Emily S. Humphrey', 'raw_affiliation_strings': ['Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', "St Vincent's Hospital Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia"], 'affiliations': [{'raw_affiliation_string': 'Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', 'institution_ids': ['https://openalex.org/I136750679']}, {'raw_affiliation_string': "St Vincent's Hospital Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia", 'institution_ids': ['https://openalex.org/I31746571', 'https://openalex.org/I4210087110']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066209341', 'display_name': 'Shih‐Ping Su', 'orcid': 'https://orcid.org/0000-0002-6669-7141'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Shih-Ping Su', 'raw_affiliation_strings': ['Cancer Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University, VIC 3800, Australia'], 'affiliations': [{'raw_affiliation_string': 'Cancer Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University, VIC 3800, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070415176', 'display_name': 'Adnan Nagrial', 'orcid': 'https://orcid.org/0000-0003-0275-2479'}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}, {'id': 'https://openalex.org/I4210087110', 'display_name': "St Vincent's Hospital", 'ror': 'https://ror.org/001kjn539', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087110', 'https://openalex.org/I4210098850']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Adnan M. Nagrial', 'raw_affiliation_strings': ['Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', "St Vincent's Hospital Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia"], 'affiliations': [{'raw_affiliation_string': 'Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', 'institution_ids': ['https://openalex.org/I136750679']}, {'raw_affiliation_string': "St Vincent's Hospital Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia", 'institution_ids': ['https://openalex.org/I31746571', 'https://openalex.org/I4210087110']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112265714', 'display_name': 'Falko Hochgräfe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36522303', 'display_name': 'Universität Greifswald', 'ror': 'https://ror.org/00r1edq15', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I36522303']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Falko Hochgräfe', 'raw_affiliation_strings': ['Competence Center Functional Genomics, University of Greifswald, F.-L-Jahnstr. 15, 17489 Greifswald, Germany'], 'affiliations': [{'raw_affiliation_string': 'Competence Center Functional Genomics, University of Greifswald, F.-L-Jahnstr. 15, 17489 Greifswald, Germany', 'institution_ids': ['https://openalex.org/I36522303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073106472', 'display_name': 'Marina Pajic', 'orcid': 'https://orcid.org/0000-0002-3871-3829'}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}, {'id': 'https://openalex.org/I4210087110', 'display_name': "St Vincent's Hospital", 'ror': 'https://ror.org/001kjn539', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087110', 'https://openalex.org/I4210098850']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Marina Pajic', 'raw_affiliation_strings': ['Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', "St Vincent's Hospital Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia"], 'affiliations': [{'raw_affiliation_string': 'Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', 'institution_ids': ['https://openalex.org/I136750679']}, {'raw_affiliation_string': "St Vincent's Hospital Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia", 'institution_ids': ['https://openalex.org/I31746571', 'https://openalex.org/I4210087110']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004062921', 'display_name': 'Gillian M. Lehrbach', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Gillian M. Lehrbach', 'raw_affiliation_strings': ['Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia'], 'affiliations': [{'raw_affiliation_string': 'Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', 'institution_ids': ['https://openalex.org/I136750679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029211283', 'display_name': 'Robert G. Parton', 'orcid': 'https://orcid.org/0000-0002-7494-5248'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Robert G. Parton', 'raw_affiliation_strings': ['Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane QLD 4072, Australia'], 'affiliations': [{'raw_affiliation_string': 'Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane QLD 4072, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025927529', 'display_name': 'Alpha S. Yap', 'orcid': 'https://orcid.org/0000-0002-1038-8956'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Alpha S. Yap', 'raw_affiliation_strings': ['Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane QLD 4072, Australia'], 'affiliations': [{'raw_affiliation_string': 'Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane QLD 4072, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084855225', 'display_name': 'Lisa G. Horvath', 'orcid': 'https://orcid.org/0000-0001-6842-9223'}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I4210093547', 'display_name': 'Chris O’Brien Lifehouse', 'ror': 'https://ror.org/00qeks103', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210093547']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Lisa G. Horvath', 'raw_affiliation_strings': ['Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', "Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW 2050, Australia"], 'affiliations': [{'raw_affiliation_string': 'Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', 'institution_ids': ['https://openalex.org/I136750679']}, {'raw_affiliation_string': "Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW 2050, Australia", 'institution_ids': ['https://openalex.org/I4210093547']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009039019', 'display_name': 'David K. Chang', 'orcid': 'https://orcid.org/0000-0002-4821-3078'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David K. Chang', 'raw_affiliation_strings': ['Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK'], 'affiliations': [{'raw_affiliation_string': 'Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089677089', 'display_name': 'Andrew V. Biankin', 'orcid': 'https://orcid.org/0000-0002-0362-5597'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Andrew V. Biankin', 'raw_affiliation_strings': ['Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK'], 'affiliations': [{'raw_affiliation_string': 'Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068746343', 'display_name': 'Jianmin Wu', 'orcid': 'https://orcid.org/0000-0002-8876-128X'}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210093964', 'display_name': 'Peking University Cancer Hospital', 'ror': 'https://ror.org/00nyxxr91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093964']}, {'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}, {'id': 'https://openalex.org/I4210087110', 'display_name': "St Vincent's Hospital", 'ror': 'https://ror.org/001kjn539', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087110', 'https://openalex.org/I4210098850']}], 'countries': ['AU', 'CN'], 'is_corresponding': True, 'raw_author_name': 'Jianmin Wu', 'raw_affiliation_strings': ['Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', 'Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, 52 Fu-Cheng Road, Hai-Dian District, Beijing 100142, China', "St Vincent's Hospital Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia"], 'affiliations': [{'raw_affiliation_string': 'Cancer Division and Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia', 'institution_ids': ['https://openalex.org/I136750679']}, {'raw_affiliation_string': 'Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, 52 Fu-Cheng Road, Hai-Dian District, Beijing 100142, China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210093964']}, {'raw_affiliation_string': "St Vincent's Hospital Clinical School, Faculty of Medicine, University of New South Wales, NSW 2052, Australia", 'institution_ids': ['https://openalex.org/I31746571', 'https://openalex.org/I4210087110']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060521527', 'display_name': 'Roger J. Daly', 'orcid': 'https://orcid.org/0000-0002-5739-8027'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Roger J. Daly', 'raw_affiliation_strings': ['Cancer Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University, VIC 3800, Australia'], 'affiliations': [{'raw_affiliation_string': 'Cancer Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University, VIC 3800, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 10, 'corresponding_author_ids': ['https://openalex.org/A5089677089', 'https://openalex.org/A5068746343', 'https://openalex.org/A5060521527'], 'corresponding_institution_ids': ['https://openalex.org/I7882870', 'https://openalex.org/I136750679', 'https://openalex.org/I20231570', 'https://openalex.org/I4210093964', 'https://openalex.org/I31746571', 'https://openalex.org/I4210087110', 'https://openalex.org/I56590836'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 2.942, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.999955, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '15', 'issue': '8', 'first_page': '2671', 'last_page': '2685'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 0.9859, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5840993}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.57350975}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.57223123}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.50282735}, {'id': 'https://openalex.org/C2777553839', 'wikidata': 'https://www.wikidata.org/wiki/Q14330986', 'display_name': 'Tyrosine phosphorylation', 'level': 3, 'score': 0.5004692}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.47110918}, {'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.44341308}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.34591076}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.30635458}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.21675974}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.18806782}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15340689}], 'mesh': [{'descriptor_ui': 'D021441', 'descriptor_name': 'Carcinoma, Pancreatic Ductal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019000', 'descriptor_name': 'Phosphotyrosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002853', 'descriptor_name': 'Chromatography, Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060066', 'descriptor_name': 'Protein Interaction Maps', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053719', 'descriptor_name': 'Tandem Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m116.058313', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/8/2671.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4974343', 'pdf_url': 'https://europepmc.org/articles/pmc4974343?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974343', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27259358', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m116.058313', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/8/2671.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'score': 0.76, 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [{'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1037320'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1083896'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1058540'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1044041'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '535903'}], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1497915798', 'https://openalex.org/W1665930447', 'https://openalex.org/W1907787906', 'https://openalex.org/W1966803171', 'https://openalex.org/W1977072117', 'https://openalex.org/W1979559554', 'https://openalex.org/W1987313243', 'https://openalex.org/W1988579615', 'https://openalex.org/W1995328918', 'https://openalex.org/W2015543753', 'https://openalex.org/W2023010129', 'https://openalex.org/W2027847170', 'https://openalex.org/W2031921149', 'https://openalex.org/W2036321220', 'https://openalex.org/W2062983115', 'https://openalex.org/W2067826589', 'https://openalex.org/W2069777211', 'https://openalex.org/W2076751064', 'https://openalex.org/W2080752012', 'https://openalex.org/W2081074104', 'https://openalex.org/W2082514169', 'https://openalex.org/W2089350319', 'https://openalex.org/W2094252120', 'https://openalex.org/W2096440150', 'https://openalex.org/W2097257853', 'https://openalex.org/W2099598705', 'https://openalex.org/W2104487671', 'https://openalex.org/W2105675816', 'https://openalex.org/W2112833912', 'https://openalex.org/W2115031656', 'https://openalex.org/W2119370602', 'https://openalex.org/W2125146087', 'https://openalex.org/W2128086717', 'https://openalex.org/W2129140055', 'https://openalex.org/W2132656693', 'https://openalex.org/W2138811970', 'https://openalex.org/W2154790710', 'https://openalex.org/W2155185697', 'https://openalex.org/W2158134441', 'https://openalex.org/W2161338384', 'https://openalex.org/W2161884651', 'https://openalex.org/W2167404368', 'https://openalex.org/W2168691181', 'https://openalex.org/W2170253702', 'https://openalex.org/W2285093314', 'https://openalex.org/W2589974889', 'https://openalex.org/W4232914613', 'https://openalex.org/W4247176160'], 'related_works': ['https://openalex.org/W2122000206', 'https://openalex.org/W2096014202', 'https://openalex.org/W2087695146', 'https://openalex.org/W2072299589', 'https://openalex.org/W1988749775', 'https://openalex.org/W1987307749', 'https://openalex.org/W1985211644', 'https://openalex.org/W1898795080', 'https://openalex.org/W1576402354', 'https://openalex.org/W1177200553'], 'abstract_inverted_index': {'Comprehensive': [0, 283], 'characterization': [1, 284], 'of': [2, 14, 35, 57, 81, 93, 114, 130, 165, 202, 212, 257, 285, 297, 318, 340, 364, 376, 397, 413, 448, 485, 495, 540, 615, 682, 697, 713, 854, 860, 867, 922, 1380, 1406, 1410, 1417, 1421, 1437, 1715, 1729, 1917, 1934, 2185, 2242, 2347, 2351, 2363, 2421, 2487, 2502, 2520, 2532, 2562, 2840, 2987, 2997, 3035, 3061, 3080, 3100, 3107, 3123, 3130, 3168, 3200, 3217, 3294, 3370, 3441, 3739, 3797, 3821, 3827, 3833, 3846, 3962, 4015, 4104, 4147, 4278, 4319, 4363, 4372, 4380, 4389, 4426, 4455, 4486, 4495, 4503, 4512, 4540], 'signaling': [3, 108, 139, 259, 286, 391, 422, 542, 2522, 2545, 3083, 3203, 3291, 3372, 3410, 3819, 3830], 'in': [4, 76, 138, 181, 287, 359, 421, 464, 722, 726, 740, 763, 908, 913, 1183, 1392, 1435, 1698, 2275, 2324, 2369, 2392, 2437, 2523, 2554, 2824, 2863, 2904, 2993, 3045, 3127, 3181, 3204, 3221, 3376, 3519, 3776, 3813, 3818, 3857, 4059, 4187, 4321, 4330, 4334, 4338, 4343, 4368, 4435, 4447, 4491, 4545], 'pancreatic': [5, 288, 583, 741, 786, 800, 1381, 1918, 2186, 2243, 2325, 2395, 2488, 2865, 2905, 2999, 3048, 3085, 3132, 3184, 3442, 3515, 3740], 'ductal': [6, 289, 567, 574, 787, 2244, 2396, 3049, 3133, 3185, 3516], 'adenocarcinoma': [7, 290, 568, 788, 2245, 3517], '(PDAC)': [8, 291, 569], 'promises': [9, 292], 'to': [10, 47, 198, 230, 248, 293, 330, 481, 513, 531, 580, 702, 719, 772, 780, 796, 864, 885, 889, 898, 1947, 1951, 2201, 2250, 2267, 2355, 2384, 2498, 2558, 3197, 3209, 3226, 3414, 3432, 3499, 3784, 3807, 3815, 3944, 3968, 4029, 4101, 4274], 'enhance': [11, 294], 'our': [12, 295], 'understanding': [13, 296, 853, 2346], 'the': [15, 62, 77, 90, 126, 131, 158, 169, 182, 200, 203, 210, 213, 217, 231, 298, 345, 360, 373, 409, 414, 441, 452, 465, 483, 486, 493, 496, 500, 514, 616, 679, 711, 714, 775, 847, 855, 865, 1377, 1404, 1418, 1719, 1914, 1929, 2268, 2348, 2370, 2559, 2985, 3101, 3124, 3230, 3290, 3453, 3462, 3507, 3736, 3759, 3795, 3828, 3834, 3882, 3899, 3933, 4094, 4130, 4133, 4136, 4223, 4231, 4307, 4369, 4436, 4448, 4472, 4480, 4492], 'molecular': [16, 299, 776, 858, 1408, 2183, 2494, 3418], 'aberrations': [17, 300, 1182, 1697, 2823], 'driving': [18, 301], 'this': [19, 249, 302, 532, 1422, 2380, 3222, 3236], 'devastating': [20, 303], 'disease,': [21, 304], 'and': [22, 68, 79, 89, 120, 145, 150, 172, 185, 269, 305, 351, 362, 372, 403, 428, 433, 455, 468, 552, 627, 784, 857, 870, 910, 916, 1968, 2203, 2246, 2261, 2338, 2398, 2418, 2442, 2491, 2500, 2535, 2846, 2907, 2989, 3040, 3097, 3121, 3170, 3178, 3212, 3412, 3428, 3459, 3493, 3496, 3788, 3824, 3881, 3981, 3999, 4043, 4057, 4079, 4141, 4172, 4205, 4213, 4262, 4341, 4385, 4433, 4460, 4508, 4543], 'may': [23, 241, 306, 524, 2353], 'identify': [24, 307, 2182], 'novel': [25, 264, 308, 547, 3401], 'therapeutic': [26, 309, 629, 2533, 2911], 'targets': [27, 310, 2534], 'as': [28, 30, 311, 313, 705, 2196, 2198, 3066, 3948, 3950, 4327], 'well': [29, 312, 2197, 3949], 'biomarkers': [31, 314, 2376, 3431], 'that': [32, 125, 238, 275, 315, 408, 521, 558, 778, 874, 2343, 2516, 2542, 2983], 'enable': [33, 316, 3825], 'stratification': [34, 317, 759, 2358, 3436], 'patients': [36, 319, 698, 1439, 1935, 3046, 3182], 'for': [37, 188, 246, 266, 279, 320, 471, 529, 549, 562, 760, 1403, 1430, 1721, 2359, 2372, 2377, 2530, 3420, 3437, 3752, 3803, 3893, 3925, 3995, 4222, 4230, 4466], 'optimal': [38, 321], 'therapy.': [39, 251, 322, 534, 900, 1953, 2360, 3438], 'Here,': [40, 323], 'we': [41, 324, 3233], 'use': [42, 325], 'immunoaffinity-coupled': [43, 326], 'high-resolution': [44, 327], 'mass': [45, 328, 588, 807, 812, 4214, 4370, 4450, 4493], 'spectrometry': [46, 329, 808, 813], 'characterize': [48, 331], 'global': [49, 332, 3215, 3241], 'tyrosine': [50, 86, 104, 152, 163, 333, 369, 387, 435, 446, 600, 828, 2543, 2897, 3063, 3201, 3218, 3407], 'phosphorylation': [51, 87, 105, 164, 334, 370, 388, 447, 3219, 3287, 3408], 'patterns': [52, 335, 1728, 1967, 3220], 'across': [53, 216, 336, 499, 3392], 'two': [54, 218, 337, 501, 849, 3393, 3842], 'large': [55, 338], 'panels': [56, 339], 'human': [58, 341, 799, 2864, 3131], 'PDAC': [59, 95, 273, 342, 378, 556, 781, 1411, 1438, 1716, 1959, 2277, 2352, 2422, 2524, 3205, 3396, 3402, 3421], 'cell': [60, 66, 72, 96, 222, 343, 349, 355, 379, 505, 3397, 3444, 3450, 3504, 3753, 3836, 3840, 3963, 4438], 'lines:': [61, 344], 'ATCC': [63, 132, 346, 415, 3454, 3500, 3853, 4095, 4232], 'series': [64, 70, 98, 133, 190, 205, 226, 347, 353, 381, 416, 473, 488, 509], '(19': [65, 348], 'lines)': [67, 350], 'TKCC': [69, 183, 352, 466, 3508, 3523, 3525, 3527, 3529, 3531, 3533, 3535, 3537, 3539, 3541, 3543, 3545, 3547, 3549, 3551, 3553, 3894, 4131, 4224], '(17': [71, 354], 'lines).': [73, 356], 'This': [74, 123, 357, 406, 881, 2514, 3416, 3810], 'resulted': [75, 358], 'identification': [78, 113, 361, 396, 2531], 'quantification': [80, 363], 'over': [82, 365], '1800': [83, 366], 'class': [84, 367], '1': [85, 368, 3449, 3873, 3877, 3885, 3969, 4331], 'sites': [88, 187, 371, 470], 'consistent': [91, 374], 'segregation': [92, 375], 'both': [94, 225, 377, 508], 'line': [97, 380, 3398, 3754, 3964], 'into': [99, 272, 382, 555, 1723, 1960, 3425, 3790, 4350, 4479], 'three': [100, 127, 214, 383, 410, 497, 4167, 4173], 'subtypes': [101, 128, 201, 215, 384, 411, 484, 498, 1725, 1961, 2184], 'with': [102, 118, 136, 142, 206, 385, 401, 419, 425, 489, 604, 833, 878, 1398, 2272, 2868, 3047, 3176, 3183, 3928, 3976, 3986, 4006, 4021, 4069, 4119, 4144, 4169, 4175, 4181, 4293, 4359, 4377, 4500], 'distinct': [103, 386], 'profiles.': [106, 389], 'Subtype-selective': [107, 390], 'networks': [109, 140, 260, 392, 423, 543], 'were': [110, 134, 196, 393, 417, 479, 3446, 3456, 3494, 3510, 3781, 3851, 3855, 3916, 3941, 4026, 4038, 4054, 4113, 4117, 4164, 4179, 4196, 4216, 4236, 4311, 4375, 4416, 4445, 4462, 4476, 4498, 4530], 'characterized': [111, 394, 621, 1936, 3404], 'by': [112, 395, 622, 1937, 3239, 3405, 3461, 3758, 3921, 4166, 4198, 4238, 4281], 'subtype-enriched': [115, 398], 'phosphosites': [116, 399], 'together': [117, 400], 'pathway': [119, 402, 1186, 1433, 1701, 2270, 2314, 2827, 3105], 'network': [121, 404, 3292, 3831], 'analyses.': [122, 405], 'revealed': [124, 407], 'characteristic': [129, 412], 'associated': [135, 141, 418, 424, 1397, 3175], 'perturbations': [137, 420], 'cell-cell': [143, 426], 'adhesion': [144, 427], 'epithelial-mesenchyme': [146, 429], 'transition,': [147, 430], 'mRNA': [148, 431], 'metabolism,': [149, 432], 'receptor': [151, 434, 827, 2313, 2321, 2896, 3039], 'kinase': [153, 436, 716, 829, 2544, 2898, 3082, 3202], '(RTK)': [154, 437], 'signaling,': [155, 438], 'respectively.': [156, 439], 'Specifically,': [157, 440], 'third': [159, 442], 'subtype': [160, 178, 443, 461, 1933], 'exhibited': [161, 227, 444, 510], 'enhanced': [162, 228, 445, 511, 3098], 'multiple': [166, 449], 'RTKs': [167, 450], 'including': [168, 451, 2440, 2843], 'EGFR,': [170, 453, 2844], 'ERBB3': [171, 454, 2845], 'MET.': [173, 456], 'Interestingly,': [174, 457], 'a': [175, 243, 263, 458, 526, 546, 723, 851, 920, 1932, 1941, 2262, 2344, 2414, 2427, 2517, 2527, 2909, 2994, 3128, 4126, 4241, 4265, 4282, 4300, 4317, 4351, 4360, 4378, 4424, 4453, 4467, 4483, 4501, 4538], 'similar': [176, 459, 3897], 'RTK-enriched': [177, 221, 460, 504], 'was': [179, 462, 1945, 3756, 3811, 3896, 3902, 3966, 4139, 4348], 'identified': [180, 191, 463, 474, 1426, 2430], 'series,': [184, 467], "'classifier'": [186, 469], 'each': [189, 472, 3839], 'using': [192, 475, 4200, 4299, 4316, 4482], 'Random': [193, 476, 823], 'Forest': [194, 477, 824], 'models': [195, 478], 'able': [197, 480], 'predict': [199, 482], 'alternate': [204, 487], 'high': [207, 490], 'accuracy,': [208, 491], 'highlighting': [209, 492], 'conservation': [211, 494], 'series.': [219, 502], 'Finally,': [220, 503], 'lines': [223, 506, 3445, 3451, 3505], 'from': [224, 507, 678, 3458, 3512, 4135, 4464], 'sensitivity': [229, 512, 1950, 2200, 2323, 3413], 'small': [232, 515], 'molecule': [233, 516], 'EGFR': [234, 517, 2269], 'inhibitor': [235, 518, 717, 2322, 2991], 'erlotinib,': [236, 519], 'indicating': [237, 520], 'their': [239, 522, 2247, 2399], 'phosphosignature': [240, 523], 'provide': [242, 262, 270, 525, 545, 553], 'predictive': [244, 527], 'biomarker': [245, 528], 'response': [247, 530, 897], 'targeted': [250, 533, 868], 'These': [252, 535, 766, 2336, 3939, 4036], 'studies': [253, 536, 2340], 'highlight': [254, 537, 768], 'how': [255, 538], 'resolution': [256, 539, 4379, 4454, 4502], 'subtype-selective': [258, 541], 'can': [261, 276, 544, 559, 2547], 'taxonomy': [265, 548, 3419], 'particular': [267, 550, 2841], 'cancers,': [268, 551, 620], 'insights': [271, 554, 3424], 'biology': [274, 557], 'be': [277, 560, 886, 2548, 3227], 'exploited': [278, 561], 'improved': [280, 563, 2356], 'patient': [281, 564, 727, 758, 1969, 2357, 3435], 'management.': [282, 565], 'Pancreatic': [566, 1178, 1693, 2136, 2819], '1The': [570], 'abbreviations': [571], 'used': [572, 3495, 3773, 3943], 'are:PDACpancreatic': [573], 'adenocarcinomaAJsadheren': [575], 'junctionsATCCAmerican': [576], 'Type': [577, 792, 3464], 'Culture': [578, 793, 3465, 3771], 'CollectionEMTepithelial': [579], 'mesenchyme': [581, 797], 'transitionHPDEhuman': [582], 'duct': [584, 801], 'epithelialIAPimmunoaffinity': [585], 'purificationLC-MS/MSLiquid': [586], 'chromatography-tandem': [587, 806], 'spectrometryMDAmean': [589], 'decrease': [590, 810], 'accuracyMSmass': [591], 'spectrometryPCAprincipal': [592], 'component': [593, 815], 'analysisPINAProtein': [594], 'Interaction': [595, 818], 'Network': [596, 819], 'AnalysispTyrphosphotyrosineQMquasimesenchymalRFRandom': [597], 'ForestRTRoom': [598], 'temperatureRTKreceptor': [599], 'kinaseTBSTTris': [601], 'Buffered': [602, 831], 'Saline': [603, 832], 'TweenTCEPtris': [605], '(2-carboxyethyl)': [606, 836, 3888], 'phosphineTFAtrifluoroacetic': [607], 'acidTJstight': [608], 'junctionsTKCCThe': [609], 'Kinghorn': [610, 843], 'Cancer': [611, 677, 844, 2137, 2871, 3087], 'Centre.': [612, 845], 'remains': [613, 762], 'one': [614], 'most': [617, 4399, 4518], 'deadly': [618], 'solid': [619], 'extremely': [623], 'poor': [624, 895, 3043, 3179], 'survival': [625, 728], 'rates': [626], 'limited': [628, 701, 3208], 'options': [630], '(1.Vogelzang': [631], 'N.J.': [632], 'Benowitz': [633], 'S.I.': [634], 'Adams': [635, 1144, 1659, 2785], 'S.': [636, 952, 956, 962, 964, 986, 1101, 1113, 1229, 1231, 1237, 1259, 1265, 1467, 1471, 1477, 1479, 1501, 1616, 1628, 1766, 1768, 1774, 1796, 1802, 1998, 2000, 2004, 2014, 2022, 2216, 2451, 2457, 2467, 2593, 2597, 2603, 2605, 2627, 2742, 2754, 2885, 2938, 2966, 3011, 3013, 3023, 3588, 3590, 3596, 3618, 3624], 'Aghajanian': [637], 'C.': [638, 958, 982, 1038, 1233, 1253, 1313, 1349, 1363, 1473, 1497, 1553, 1770, 1790, 1850, 1886, 1900, 1992, 2016, 2122, 2151, 2298, 2389, 2455, 2465, 2599, 2623, 2679, 2976, 3325, 3592, 3612, 3672, 3708, 3722], 'Chang': [639, 945, 1067, 1202, 1460, 1582, 1739, 1973, 2586, 2708, 3561], 'S.M.': [640, 1177, 1373, 1692, 1910, 2179, 2818, 3732], 'Dreyer': [641], 'Z.E.': [642], 'Janne': [643], 'P.A.': [644, 1109, 1143, 1624, 1658, 2750, 2784], 'Ko': [645, 2227], 'A.H.': [646, 2228], 'Masters': [647], 'G.A.': [648, 2306], 'Odenike': [649], 'O.': [650, 980, 1249, 1495, 1786, 2008, 2163, 2621, 3025, 3608], 'Patel': [651], 'J.D.': [652, 1173, 1688, 2814], 'Roth': [653], 'B.J.': [654], 'Samlowski': [655], 'W.E.': [656, 1058, 1573, 2143, 2699], 'Seidman': [657], 'A.D.': [658], 'Tap': [659], 'W.D.': [660], 'Temel': [661], 'J.S.': [662, 1028, 1305, 1325, 1543, 1842, 1862, 2078, 2100, 2669, 3664, 3684], 'Von': [663], 'Roenn': [664], 'J.H.': [665], 'Kris': [666], 'M.G.': [667], 'Clinical': [668, 683], 'cancer': [669, 861, 1179, 1694, 2489, 2499, 2820, 2866, 2906, 3297, 3443], 'advances': [670, 739, 2391], '2011:': [671], 'Annual': [672], 'Report': [673], 'on': [674, 3904, 3918, 4125, 4218, 4264], 'Progress': [675], 'Against': [676], 'American': [680, 791, 3463], 'Society': [681], 'Oncology.J.': [684], 'Clin.': [685], 'Oncol.': [686], '2012;': [687, 1188, 1703, 2829], '30:': [688], '88-109Crossref': [689], 'PubMed': [690, 751, 1191, 1386, 1706, 1923, 2191, 2256, 2331, 2408, 2509, 2832, 2918, 3005, 3054, 3092, 3139, 3191, 3303, 3387, 3745], 'Scopus': [691, 752, 1192, 1387, 1707, 1924, 2192, 2257, 2332, 2409, 2510, 2833, 2919, 3006, 3055, 3093, 3140, 3192, 3304, 3388, 3746], '(85)': [692, 3094], 'Google': [693, 754, 1194, 1389, 1709, 1926, 2194, 2259, 2334, 2411, 2512, 2835, 2876, 2921, 3008, 3057, 3095, 3142, 3194, 3306, 3390, 3748], 'Scholar).': [694, 755, 1927, 2335, 2412, 2513, 3195, 3749], 'Postoperative': [695], 'treatment': [696, 872], 'is': [699, 2540, 3174], 'largely': [700], 'chemotherapeutics,': [703], 'such': [704, 876, 3065], 'gemcitabine,': [706], 'nab-paclitaxel': [707], 'or': [708, 2374, 3144, 3799, 3957, 3973, 4087, 4227], 'Folfirinox,': [709], 'although': [710, 2379], 'addition': [712, 2557, 3796], 'EGFR-directed': [715], 'erlotinib': [718, 2202, 2273], 'gemcitabine': [720, 2204], 'results': [721], 'modest': [724], 'improvement': [725], '(2.Paulson': [729], 'A.S.': [730], 'Tran': [731], 'Cao': [732], 'H.S.': [733, 2226], 'Tempero': [734, 1136, 1356, 1651, 1893, 2233, 2777, 3715], 'M.A.': [735, 1137, 1357, 1652, 1894, 2234, 2778, 3716], 'Lowy': [736], 'A.M.': [737, 942, 1016, 1201, 1279, 1287, 1457, 1531, 1738, 1816, 1824, 1980, 2056, 2583, 2657, 3560, 3638, 3646], 'Therapeutic': [738], 'cancer.Gastroenterology.': [742], '2013;': [743, 3188], '144:': [744], '1316-1326Abstract': [745], 'Full': [746, 748, 3382, 3384], 'Text': [747, 749, 3383, 3385], 'PDF': [750, 3386], '(237)': [753], 'In': [756, 1928, 1954, 2413, 2556, 3229], 'addition,': [757, 1955], 'therapy': [761], 'its': [764, 894], 'infancy.': [765], 'factors': [767], 'an': [769, 1427, 2900, 3213, 4201, 4275, 4386, 4509], 'urgent': [770], 'need': [771], 'better': [773], 'understand': [774], 'mechanisms': [777, 3427], 'contribute': [779], 'development,': [782], 'progression': [783], 'heterogeneity.': [785], 'adheren': [789], 'junctions': [790, 841], 'Collection': [794, 3466], 'epithelial': [795, 802], 'transition': [798], 'immunoaffinity': [803, 4060], 'purification': [804, 4061], 'Liquid': [805], 'mean': [809], 'accuracy': [811], 'principal': [814], 'analysis': [816], 'Protein': [817], 'Analysis': [820], 'phosphotyrosine': [821, 3243, 3371], 'quasimesenchymal': [822], 'Room': [825], 'temperature': [826, 3937], 'Tris': [830], 'Tween': [834], 'tris': [835, 3887], 'phosphine': [837, 3889], 'trifluoroacetic': [838, 4184], 'acid': [839, 4185, 4326], 'tight': [840], 'The': [842, 2894, 3030, 3891, 4346, 4396, 4515], 'Over': [846], 'last': [848], 'decades,': [850], 'deeper': [852], 'genetic': [856], 'basis': [859, 1720], 'has': [862, 883, 1412, 2382, 3206, 3224], 'led': [863], 'development': [866], 'therapeutics': [869], 'personalized': [871], 'strategies': [873], 'combine': [875], 'approaches': [877, 2365], 'companion': [879], 'biomarkers.': [880], 'paradigm': [882], 'yet': [884, 2383, 3225], 'successfully': [887], 'applied': [888, 2368], 'PDAC,': [890, 2378], 'which': [891], 'likely': [892, 2496], 'explains': [893], 'overall': [896], 'adjuvant': [899], 'Although': [901], 'almost': [902], 'all': [903], 'PDACs': [904], 'harbor': [905], 'activating': [906, 2563], 'mutations': [907, 912, 1391, 2565], 'KRAS,': [909], 'inactivating': [911], 'TP53,': [914], 'SMAD4': [915], 'CDKN2A': [917], 'occur': [918], 'at': [919, 2550, 3935, 3983, 4001, 4122, 4313, 4382, 4423, 4452, 4457, 4505, 4537], 'frequency': [921], '>': [923, 4405, 4524], '30%': [924], '(3.Biankin': [925, 1440, 2566], 'A.V.': [926, 974, 1299, 1371, 1441, 1489, 1836, 1908, 2072, 2177, 2567, 2615, 3279, 3658, 3730], 'Waddell': [927, 1262, 1442, 1799, 2019, 2174, 2568, 3621], 'N.': [928, 998, 1046, 1048, 1092, 1103, 1197, 1243, 1263, 1321, 1443, 1513, 1561, 1563, 1607, 1618, 1734, 1780, 1800, 1858, 2020, 2028, 2094, 2175, 2483, 2569, 2639, 2687, 2689, 2733, 2744, 2948, 3017, 3556, 3602, 3622, 3680], 'Kassahn': [929, 1204, 1444, 1741, 2029, 2570, 3563], 'K.S.': [930, 1205, 1445, 1742, 2030, 2571, 3564], 'Gingras': [931, 1446, 1981, 2572], 'M.C.': [932, 1217, 1447, 1754, 1982, 1990, 2573, 3576], 'Muthuswamy': [933, 1448, 2574], 'L.B.': [934, 1449, 2575], 'Johns': [935, 1208, 1450, 1745, 1977, 2576, 3567], 'A.L.': [936, 1209, 1451, 1746, 1978, 2577, 3568], 'Miller': [937, 1210, 1452, 1747, 1983, 2578, 3569], 'D.K.': [938, 946, 1203, 1453, 1461, 1740, 1974, 1984, 2579, 2587, 3562], 'Wilson': [939, 1238, 1454, 1775, 2025, 2580, 3597], 'P.J.': [940, 1239, 1455, 1776, 2026, 2581, 3598], 'Patch': [941, 1200, 1456, 1737, 1979, 2582, 3559], 'Wu': [943, 1051, 1268, 1458, 1566, 1805, 2045, 2584, 2692, 3627], 'J.': [944, 1066, 1269, 1281, 1459, 1581, 1806, 1818, 2046, 2064, 2106, 2218, 2220, 2284, 2292, 2469, 2477, 2585, 2707, 3317, 3321, 3337, 3341, 3345, 3349, 3365, 3628, 3640], 'Cowley': [947, 1272, 1462, 1809, 2049, 2588, 3631], 'M.J.': [948, 1245, 1273, 1463, 1782, 1810, 2012, 2050, 2589, 3283, 3367, 3604, 3632], 'Gardiner': [949, 1464, 2590], 'B.B.': [950, 1465, 2591], 'Song': [951, 1258, 1466, 1795, 2592, 3617], 'Harliwong': [953, 1226, 1468, 1763, 1995, 2594, 3585], 'I.': [954, 976, 1227, 1303, 1469, 1491, 1764, 1840, 1996, 2076, 2139, 2485, 2595, 2617, 3586, 3662], 'Idrisoglu': [955, 1228, 1470, 1765, 1997, 2596, 3587], 'Nourse': [957, 1232, 1472, 1769, 1991, 2598, 3591], 'Nourbakhsh': [959, 1234, 1474, 1771, 2001, 2600, 3593], 'E.': [960, 1235, 1241, 1475, 1772, 1778, 2002, 2601, 2944, 3594, 3600], 'Manning': [961, 1230, 1476, 1767, 1999, 2602, 3589], 'Wani': [963, 1236, 1478, 1773, 2003, 2604, 3595], 'Gongora': [965, 1480, 2606], 'M.': [966, 968, 978, 1004, 1054, 1082, 1133, 1199, 1271, 1301, 1351, 1481, 1483, 1493, 1519, 1569, 1597, 1648, 1736, 1808, 1838, 1888, 2048, 2068, 2074, 2214, 2302, 2308, 2473, 2607, 2609, 2619, 2645, 2695, 2723, 2774, 2859, 2952, 3019, 3115, 3254, 3333, 3558, 3630, 3660, 3710], 'Pajic': [967, 1198, 1482, 1735, 2067, 2608, 3557], 'Scarlett': [969, 1296, 1484, 1833, 2069, 2610, 3655], 'C.J.': [970, 1076, 1297, 1485, 1591, 1834, 2070, 2611, 2717, 3656], 'Gill': [971, 1358, 1486, 1895, 2168, 2612, 3717], 'A.J.': [972, 1219, 1359, 1487, 1756, 1896, 2169, 2613, 3578, 3718], 'Pinho': [973, 1298, 1488, 1835, 2071, 2614, 3657], 'Rooman': [975, 1302, 1490, 1839, 2075, 2616, 3661], 'Anderson': [977, 1244, 1492, 1781, 2011, 2618, 3603], 'Holmes': [979, 1248, 1494, 1785, 2007, 2620, 3607], 'Leonard': [981, 1252, 1496, 1789, 2015, 2622, 3611], 'Taylor': [983, 1260, 1498, 1797, 2031, 2624, 3619], 'D.': [984, 1088, 1105, 1211, 1261, 1333, 1499, 1603, 1620, 1748, 1798, 1870, 2032, 2132, 2238, 2445, 2481, 2625, 2729, 2746, 2946, 3263, 3273, 3355, 3570, 3620, 3692], 'Wood': [985, 1264, 1500, 1801, 2021, 2626, 3114, 3623], 'Xu': [987, 1266, 1502, 1803, 2023, 2628, 3625], 'Q.': [988, 1267, 1503, 1804, 2024, 2629, 3313, 3626], 'Nones': [989, 1212, 1504, 1749, 1975, 2630, 3571], 'K.': [990, 1040, 1068, 1084, 1213, 1215, 1315, 1505, 1555, 1583, 1599, 1750, 1752, 1852, 1976, 2034, 2088, 2096, 2104, 2631, 2681, 2709, 2725, 2964, 3027, 3309, 3323, 3572, 3574, 3674], 'Fink': [991, 1246, 1506, 1783, 2005, 2632, 3605], 'J.L.': [992, 1008, 1247, 1507, 1523, 1784, 2633, 2649, 3162, 3606], 'Christ': [993, 1224, 1508, 1761, 1985, 2634, 3583], 'A.': [994, 1020, 1026, 1044, 1086, 1090, 1117, 1161, 1289, 1295, 1319, 1337, 1365, 1509, 1535, 1541, 1559, 1601, 1605, 1632, 1676, 1826, 1832, 1856, 1874, 1902, 2036, 2062, 2066, 2092, 2110, 2157, 2208, 2280, 2300, 2449, 2635, 2661, 2667, 2685, 2727, 2731, 2758, 2802, 2893, 2926, 2930, 2954, 2960, 3150, 3257, 3265, 3271, 3311, 3315, 3648, 3654, 3678, 3696, 3724], 'Bruxner': [995, 1222, 1510, 1759, 1987, 2636, 3581], 'T.': [996, 1078, 1511, 1593, 2637, 2719, 2942], 'Cloonan': [997, 1242, 1512, 1779, 2027, 2638, 3601], 'Kolle': [999, 1514, 2640], 'G.': [1000, 1135, 1353, 1355, 1515, 1650, 1890, 1892, 2130, 2459, 2641, 2776, 2883, 2936, 3712, 3714], 'Newell': [1001, 1254, 1516, 1791, 2017, 2642, 3613], 'F.': [1002, 1050, 1255, 1517, 1565, 1792, 2018, 2102, 2643, 2691, 3073, 3246, 3614], 'Pinese': [1003, 1270, 1518, 1807, 2047, 2644, 3253, 3629], 'Mead': [1005, 1520, 2646], 'R.S.': [1006, 1521, 2647], 'Humphris': [1007, 1280, 1522, 1817, 2063, 2648, 3639], 'Kaplan': [1009, 1524, 2650], 'W.': [1010, 1525, 2651, 2956], 'Jones': [1011, 1276, 1526, 1813, 2051, 2652, 2973, 3635], 'M.D.': [1012, 1277, 1527, 1814, 2052, 2653, 3636], 'Colvin': [1013, 1292, 1528, 1829, 2053, 2654, 3651], 'E.K.': [1014, 1293, 1529, 1830, 2054, 2655, 3652], 'Nagrial': [1015, 1278, 1530, 1815, 2055, 2656, 3637], 'Humphrey': [1017, 1290, 1532, 1827, 2057, 2658, 3649], 'E.S.': [1018, 1291, 1533, 1828, 2058, 2659, 3650], 'Chou': [1019, 1294, 1534, 1831, 2065, 2660, 3653], 'Chin': [1021, 1284, 1536, 1821, 2009, 2662, 3643], 'V.T.': [1022, 1537, 2663], 'Chantrill': [1023, 1282, 1538, 1819, 2059, 2664, 3641], 'L.A.': [1024, 1283, 1539, 1820, 2060, 2665, 3642], 'Mawson': [1025, 1288, 1540, 1825, 2061, 2666, 3647], 'Samra': [1027, 1304, 1542, 1841, 2077, 2668, 3663], 'Kench': [1029, 1306, 1544, 1843, 2079, 2670, 3665], 'J.G.': [1030, 1064, 1307, 1545, 1579, 1844, 2080, 2671, 2705, 3666], 'Lovell': [1031, 1546, 2081, 2672], 'J.A.': [1032, 1309, 1547, 1846, 2082, 2673, 3668], 'Daly': [1033, 1548, 2674, 3284], 'R.J.': [1034, 1549, 2675, 3285], 'Merrett': [1035, 1310, 1550, 1847, 2083, 2676, 3669], 'N.D.': [1036, 1311, 1551, 1848, 2084, 2677, 3670], 'Toon': [1037, 1312, 1552, 1849, 2085, 2678, 3671], 'Epari': [1039, 1314, 1554, 1851, 2087, 2680, 3673], 'Nguyen': [1041, 1316, 1556, 1853, 2089, 2682, 3675], 'N.Q.': [1042, 1317, 1557, 1854, 2090, 2683, 3676], 'Barbour': [1043, 1318, 1558, 1855, 2091, 2684, 3677], 'Zeps': [1045, 1320, 1560, 1857, 2093, 2686, 3679], 'Kakkar': [1047, 1562, 2688], 'Zhao': [1049, 1564, 2690], 'Y.Q.': [1052, 1567, 2693], 'Wang': [1053, 1568, 2694, 2933, 3151, 3165], 'Muzny': [1055, 1570, 2696], 'D.M.': [1056, 1571, 2141, 2697], 'Fisher': [1057, 1572, 2142, 2698], 'Brunicardi': [1059, 1574, 2700], 'F.C.': [1060, 1575, 2701], 'Hodges': [1061, 1576, 2702], 'S.E.': [1062, 1577, 2703], 'Reid': [1063, 1578, 2704], 'Drummond': [1065, 1580, 2706], 'Han': [1069, 1584, 2710], 'Y.': [1070, 1585, 2447, 2711, 2851, 3021, 3327, 3329], 'Lewis': [1071, 1586, 2712], 'L.R.': [1072, 1587, 2713], 'Dinh': [1073, 1588, 2714], 'H.': [1074, 1589, 2715, 2849, 2891, 2932, 2934, 3015, 3029, 3152, 3166, 3319], 'Buhay': [1075, 1590, 2716], 'Beck': [1077, 1592, 2718], 'Timms': [1079, 1594, 2720], 'L.': [1080, 1595, 2006, 2038, 2040, 2044, 2224, 2475, 2721, 2950, 3113, 3248, 3335], 'Sam': [1081, 1596, 2722], 'Begley': [1083, 1598, 2724], 'Brown': [1085, 1600, 2726], 'Pai': [1087, 1602, 2728], 'Panchal': [1089, 1604, 2730], 'Buchner': [1091, 1606, 2732], 'De': [1093, 1608, 2734], 'Borja': [1094, 1609, 2735], 'R.': [1095, 1329, 1331, 1610, 1866, 1868, 2108, 2128, 2471, 2736, 2940, 3267, 3269, 3339, 3688, 3690], 'Denroche': [1096, 1611, 2737], 'R.E.': [1097, 1612, 2738], 'Yung': [1098, 1613, 2739], 'C.K.': [1099, 1614, 2740], 'Serra': [1100, 1615, 2741], 'Onetto': [1102, 1617, 2743], 'Mukhopadhyay': [1104, 1619, 2131, 2745], 'Tsao': [1106, 1621, 2747], 'M.S.': [1107, 1622, 2748, 2853], 'Shaw': [1108, 1623, 2749], 'Petersen': [1110, 1625, 2133, 2751], 'G.M.': [1111, 1626, 2134, 2752, 3259], 'Gallinger': [1112, 1627, 2753], 'Hruban': [1114, 1334, 1629, 1871, 2148, 2755, 3693], 'R.H.': [1115, 1335, 1630, 1872, 2149, 2756, 3694], 'Maitra': [1116, 1336, 1631, 1873, 2109, 2299, 2757, 2892, 3695], 'Iacobuzio-Donahue': [1118, 1338, 1633, 1875, 2111, 2297, 2759, 3697], 'C.A.': [1119, 1339, 1634, 1876, 2112, 2760, 2881, 3698], 'Schulick': [1120, 1635, 2761], 'R.D.': [1121, 1636, 2762, 3363], 'Wolfgang': [1122, 1340, 1637, 1877, 2113, 2763, 3699], 'C.L.': [1123, 1341, 1638, 1878, 2114, 2764, 3700], 'Morgan': [1124, 1342, 1639, 1879, 2115, 2765, 3701], 'R.A.': [1125, 1175, 1343, 1640, 1690, 1880, 2116, 2171, 2766, 2816, 2978, 3160, 3702], 'Lawlor': [1126, 1344, 1641, 1881, 2117, 2767, 3703], 'R.T.': [1127, 1345, 1642, 1882, 2118, 2768, 3704], 'Capelli': [1128, 1643, 2125, 2769], 'P.': [1129, 1207, 1644, 1744, 1972, 2126, 2210, 2288, 2461, 2463, 2770, 2924, 2928, 2974, 3275, 3566], 'Corbo': [1130, 1346, 1645, 1883, 2119, 2771, 3705], 'V.': [1131, 1285, 1347, 1646, 1822, 1884, 2010, 2120, 2453, 2772, 3644, 3706], 'Scardoni': [1132, 1647, 2773], 'Tortora': [1134, 1354, 1649, 1891, 2129, 2775, 3713], 'Mann': [1138, 1653, 2779], 'K.M.': [1139, 1654, 2780], 'Jenkins': [1140, 1655, 2781], 'N.A.': [1141, 1656, 2782], 'Perez-Mancera': [1142, 1657, 2783], 'D.J.': [1145, 1660, 2786, 3277], 'Largaespada': [1146, 1661, 2787], 'D.A.': [1147, 1155, 1169, 1662, 1670, 1684, 2167, 2788, 2796, 2810, 2855], 'Wessels': [1148, 1663, 2789], 'L.F.': [1149, 1664, 2790], 'Rust': [1150, 1665, 2791], 'A.G.': [1151, 1666, 2792], 'Stein': [1152, 1667, 2793], 'L.D.': [1153, 1668, 2794], 'Tuveson': [1154, 1669, 2795], 'Copeland': [1156, 1671, 2797], 'N.G.': [1157, 1672, 2798], 'Musgrove': [1158, 1366, 1673, 1903, 2158, 2799, 3725], 'E.A.': [1159, 1367, 1674, 1904, 2159, 2206, 2800, 3726], 'Scarpa': [1160, 1364, 1675, 1901, 2156, 2801, 3723], 'Eshleman': [1162, 1360, 1677, 1897, 2146, 2803, 3719], 'J.R.': [1163, 1361, 1678, 1898, 2147, 2804, 3119, 3720], 'Hudson': [1164, 1679, 2805], 'T.J.': [1165, 1223, 1680, 1760, 1988, 2806, 3582], 'Sutherland': [1166, 1681, 2164, 2807, 3280], 'R.L.': [1167, 1682, 2165, 2808, 3281], 'Wheeler': [1168, 1683, 2166, 2809], 'Pearson': [1170, 1368, 1685, 1905, 2172, 2811, 3727], 'J.V.': [1171, 1369, 1686, 1906, 2173, 2812, 3728], 'McPherson': [1172, 1687, 2813], 'Gibbs': [1174, 1689, 2170, 2815], 'Grimmond': [1176, 1372, 1691, 1909, 2178, 2817, 3731], 'genomes': [1180, 1375, 1695, 1912, 1939, 2821, 3734], 'reveal': [1181, 1696, 2822], 'axon': [1184, 1431, 1699, 2825], 'guidance': [1185, 1432, 1700, 2826], 'genes.Nature.': [1187, 1702, 2828], '491:': [1189, 1704, 2830], '399-405Crossref': [1190, 1705, 2831], '(1513)': [1193, 1708, 2834], 'Scholar,': [1195, 2877, 2922, 3009, 3307], '4.Waddell': [1196], 'Bailey': [1206, 1743, 2160, 3565], 'Quek': [1214, 1751, 2033, 3573], 'Quinn': [1216, 1753, 1989, 3575], 'Robertson': [1218, 1755, 2035, 3577], 'Fadlullah': [1220, 1757, 3579], 'M.Z.': [1221, 1758, 3580], 'A.N.': [1225, 1762, 1986, 3584], 'Markham': [1240, 1777, 3599], 'Kazakoff': [1250, 1787, 2013, 3609], 'S.H.': [1251, 1788, 3610], 'Poudel': [1256, 1793, 3615], 'B.': [1257, 1794, 2124, 2290, 2294, 3353, 3616], 'Lee': [1274, 1811, 3155, 3322, 3633], 'H.C.': [1275, 1812, 3634], 'Steinmann': [1286, 1823, 3645], 'Giry-Laterriere': [1300, 1837, 2073, 3659], 'Pettitt': [1308, 1845, 3667], 'Jamieson': [1322, 1859, 2097, 3681], 'N.B.': [1323, 1860, 2098, 3077, 3682], 'Graham': [1324, 1861, 2099, 3683], 'Niclou': [1326, 1863, 3685], 'S.P.': [1327, 1864, 3359, 3686], 'Bjerkvig': [1328, 1865, 3687], 'Grutzmann': [1330, 1867, 2107, 3689], 'Aust': [1332, 1869, 3691], 'Bassi': [1348, 1885, 2121, 3707], 'Falconi': [1350, 1887, 3709], 'Zamboni': [1352, 1889, 3711], 'Pilarsky': [1362, 1899, 2150, 3721], 'Biankin': [1370, 1907, 2176, 3278, 3729], 'Whole': [1374, 1911, 3733], 'redefine': [1376, 1913, 3735], 'mutational': [1378, 1915, 1943, 3737], 'landscape': [1379, 1420, 1916, 3738], 'cancer.Nature.': [1382, 1919, 2187, 3741], '2015;': [1383, 1920, 2405, 3002, 3742], '518:': [1384, 1921, 3743], '495-501Crossref': [1385, 1922, 3744], '(1687)': [1388, 1925, 3747], 'Scholar),': [1390, 1710, 2260, 2836], 'these': [1393, 2837], 'genes': [1394, 1434], 'are': [1395, 3774], 'not': [1396], 'clinically': [1399], "'actionable'": [1400], 'phenotypes.': [1401], 'Evidence': [1402], 'existence': [1405], 'different': [1407, 2552, 3835], 'phenotypes': [1409], 'been': [1413, 2367, 3207], 'found': [1414], 'through': [1415], 'exploration': [1416], 'genomic': [1419, 1730, 2337], 'disease.': [1423], 'Exome': [1424], 'sequencing': [1425, 1714], 'unsuspected': [1428], 'role': [1429], '∼20%': [1436], 'whereas': [1711], 'whole': [1712], 'genome': [1713], 'specimens': [1717], 'provided': [1718], 'classification': [1722], 'four': [1724], 'based': [1726, 3903], 'upon': [1727], 'structural': [1731], 'variation': [1732], '(4.Waddell': [1733, 3555], 'latter': [1930], 'study,': [1931, 2416, 3232], 'unstable': [1938], 'and/or': [1940], 'BRCA': [1942], 'signature': [1944, 2265], 'demonstrated': [1946], 'have': [1948, 2366, 3234], 'increased': [1949, 2435, 3059], 'platinum-based': [1952], 'transcript': [1956], 'profiling': [1957, 3244, 3288], 'subclassifies': [1958], 'exhibiting': [1962, 2434, 4161], 'contrasting': [1963, 3406], 'histopathogical': [1964], 'characteristics,': [1965], 'mutation': [1966], 'outcome': [1970], '(5.Bailey': [1971], 'Murtaugh': [1993], 'L.C.': [1994], 'Pantano': [2037], 'Mincarelli': [2039], 'Sanchez': [2041, 2947], 'L.N.': [2042], 'Evers': [2043], 'C.W.': [2086], 'Moran-Jones': [2095], 'Duthie': [2101], 'Oien': [2103], 'Hair': [2105], 'Rusev': [2123], 'Salvia': [2127], 'Australian': [2135], 'Genome,': [2138], 'Munzy': [2140], 'Karim': [2144], 'S.A.': [2145, 3250], 'Morton': [2152], 'J.P.': [2153], 'Sansom': [2154], 'O.J.': [2155], 'U.M.': [2161], 'Hofmann': [2162], 'Genomic': [2180], 'analyses': [2181], '2016;': [2188], '531:': [2189], '47-52Crossref': [2190], '(1975)': [2193], 'Scholar)': [2195, 3143, 3391], 'differential': [2199], '(6.Collisson': [2205], 'Sadanandam': [2207], 'Olson': [2209], 'Gibb': [2211], 'W.J.': [2212], 'Truitt': [2213], 'Gu': [2215, 3360], 'Cooc': [2217], 'Weinkle': [2219], 'Kim': [2221], 'G.E.': [2222], 'Jakkula': [2223], 'Feiler': [2225], 'Olshen': [2229], 'A.B.': [2230], 'Danenberg': [2231], 'K.L.': [2232], 'Spellman': [2235], 'P.T.': [2236], 'Hanahan': [2237], 'Gray': [2239], 'J.W.': [2240], 'Subtypes': [2241], 'differing': [2248], 'responses': [2249], 'therapy.Nat.': [2251], 'Med.': [2252], '2011;': [2253], '17:': [2254], '500-503Crossref': [2255], '(1054)': [2258], 'gene': [2263, 2315], 'expression': [2264, 2436, 2862, 3173], 'corresponding': [2266], 'correlates': [2271, 2867], 'responsiveness': [2274], 'primary': [2276, 3513], 'xenografts': [2278, 3518], '(7.Jimeno': [2279], 'Tan': [2281, 3330], 'A.C.': [2282], 'Coffa': [2283], 'Rajeshkumar': [2285], 'N.V.': [2286], 'Kulesza': [2287], 'Rubio-Viqueira': [2289], 'Wheelhouse': [2291], 'Diosdado': [2293], 'Messersmith': [2295], 'W.A.': [2296], 'Varella-Garcia': [2301], 'Hirsch': [2303], 'F.R.': [2304], 'Meijer': [2305], 'Hidalgo': [2307], 'Coordinated': [2309], 'epidermal': [2310, 2318, 3036], 'growth': [2311, 2319, 3037, 3801], 'factor': [2312, 2320, 3038], 'overexpression': [2316, 2839, 3034, 3122], 'predicts': [2317], 'cancer.Cancer': [2326, 3000], 'Res.': [2327, 2872, 3001, 3299], '2008;': [2328], '68:': [2329], '2841-2849Crossref': [2330], '(79)': [2333], 'transcriptomic': [2339], 'strongly': [2341], 'suggest': [2342], 'greater': [2345], 'phenotypic': [2349], 'heterogeneity': [2350], 'lead': [2354], 'A': [2361], 'variety': [2362], 'proteomics': [2364], 'search': [2371], 'diagnostic': [2373], 'prognostic': [2375, 2902], 'work': [2381], 'achieve': [2385], 'clinical': [2386, 2401], 'impact': [2387], '(8.Roesli': [2388], 'Recent': [2390], 'proteomically': [2393], 'subtyping': [2394], 'adenocarcinomas': [2397], 'potential': [2400, 3430], 'impact.Expert': [2402], 'Rev.': [2403], 'Proteomics.': [2404], '12:': [2406], '5-8Crossref': [2407], '(2)': [2410], 'recent': [2415], 'proteomic': [2417], 'phosphoproteomic': [2419], 'interrogation': [2420, 3199], 'versus': [2423], 'normal': [2424], 'tissue': [2425], 'via': [2426], 'LC-MS/MS': [2428], 'workflow': [2429], 'several': [2431, 2551], 'protein': [2432], 'kinases': [2433, 3375], 'tumor': [2438, 2869, 3041], 'tissue,': [2439], 'HIPK1': [2441], 'MLCK': [2443], '(9.Britton': [2444], 'Zen': [2446], 'Quaglia': [2448], 'Selzer': [2450], 'Mitra': [2452], 'Lobetaner': [2454], 'Jung': [2456], 'Bohm': [2458], 'Schmid': [2460], 'Prefot': [2462], 'Hoehle': [2464], 'Koncarevic': [2466], 'Gee': [2468], 'Nicholson': [2470], 'Ward': [2472], 'Castellano': [2474], 'Stebbing': [2476], 'Zucht': [2478], 'H.D.': [2479], 'Sarker': [2480], 'Heaton': [2482], 'Pike': [2484], 'Quantification': [2486], 'proteome': [2490], 'phosphorylome:': [2492], 'indicates': [2493], 'events': [2495, 2982], 'contributing': [2497], 'activity': [2501], 'drug': [2503], 'targets.PloS': [2504], 'One.': [2505], '2014;': [2506], '9:': [2507, 3090], 'e90948Crossref': [2508], '(44)': [2511], 'suggests': [2515], 'comprehensive': [2518], 'survey': [2519, 3216, 3369, 4489], 'deregulated': [2521, 2549], 'might': [2525], 'represent': [2526], 'fruitful': [2528], 'strategy': [2529], 'disease': [2536, 3426], 'subclassification.': [2537], 'Furthermore,': [2538], 'it': [2539], 'well-established': [2541], 'pathways': [2546], 'levels': [2553], 'PDAC.': [2555], 'near-universal': [2560], 'presence': [2561], 'KRAS': [2564], 'include:': [2838], 'RTKs,': [2842], 'AXL': [2847], '(10.Friess': [2848], 'Yamanaka': [2850], 'Kobrin': [2852], 'Do': [2854], 'Buchler': [2856], 'M.W.': [2857], 'Korc': [2858], 'Enhanced': [2860], 'erbB-3': [2861], 'progression.Clin.': [2870], '1995;': [2873], '1:': [2874], '1413-1420PubMed': [2875], '11.Koorstra': [2878], 'J.B.': [2879, 2970, 3164], 'Karikari': [2880], 'Feldmann': [2882], 'Bisht': [2884], 'Rojas': [2886], 'P.L.': [2887], 'Offerhaus': [2888], 'G.J.': [2889], 'Alvarez': [2890], 'Axl': [2895], 'confers': [2899], 'adverse': [2901], 'influence': [2903], 'represents': [2908], 'new': [2910, 3417], 'target.Cancer': [2912], 'Biol.': [2913], 'Therapy.': [2914], '2009;': [2915], '8:': [2916], '618-626Crossref': [2917], '(148)': [2920], '12.Pettazzoni': [2923], 'Viale': [2925], 'Shah': [2927], 'Carugo': [2929], 'Ying': [2931], 'Genovese': [2935], 'Seth': [2937], 'Minelli': [2939], 'Green': [2941], 'Huang-Hobbs': [2943], 'Corti': [2945], 'Nezi': [2949], 'Marchesini': [2951], 'Kapoor': [2953], 'Yao': [2955], 'Francesco': [2957], 'M.E.': [2958], 'Petrocchi': [2959], 'Deem': [2961], 'A.K.': [2962], 'Scott': [2963], 'Colla': [2965], 'Mills': [2967], 'G.B.': [2968], 'Fleming': [2969, 3163], 'Heffernan': [2971], 'T.P.': [2972], 'Toniatti': [2975], 'DePinho': [2977], 'Draetta': [2979], 'G.F.': [2980], 'Genetic': [2981], 'limit': [2984], 'efficacy': [2986], 'MEK': [2988], 'RTK': [2990], 'therapies': [2992], 'mouse': [2995], 'model': [2996], 'KRAS-driven': [2998], '75:': [3003], '1091-1101Crossref': [3004], '(53)': [3007], '13.Ueda': [3010], 'Ogata': [3012], 'Tsuda': [3014], 'Kawarabayashi': [3016], 'Kimura': [3018], 'Sugiura': [3020], 'Tamai': [3022], 'Matsubara': [3024], 'Hatsuse': [3026], 'Mochizuki': [3028], 'correlation': [3031], 'between': [3032], 'cytoplasmic': [3033], 'aggressiveness:': [3042], 'prognosis': [3044, 3180], 'adenocarcinoma.Pancreas.': [3050], '2004;': [3051], '29:': [3052], 'e1-8Crossref': [3053], '(222)': [3056], 'Scholar);': [3058, 3096], 'activation': [3060, 3099], 'nonreceptor': [3062], 'kinases,': [3064], 'Src': [3067], '(14.Nagaraj': [3068], 'N.S.': [3069], 'Smith': [3070, 3352], 'J.J.': [3071], 'Revetta': [3072], 'Washington': [3074], 'M.K.': [3075], 'Merchant': [3076], 'Targeted': [3078], 'inhibition': [3079], 'SRC': [3081], 'attenuates': [3084], 'tumorigenesis.Mol.': [3086], 'Therapeutics.': [3088], '2010;': [3089, 3300], '2322-2332Crossref': [3091], 'phosphatidylinositol': [3102], '3-kinase': [3103], '(PI3K)': [3104], 'because': [3106, 3820], 'AKT2': [3108, 3125], 'amplification': [3109], '(15.Ruggeri': [3110], 'B.A.': [3111], 'Huang': [3112], 'Cheng': [3116], 'J.Q.': [3117], 'Testa': [3118], 'Amplification': [3120], 'oncogene': [3126], 'subset': [3129], 'adenocarcinomas.Mol.': [3134], 'Carcinogenesis.': [3135], '1998;': [3136], '21:': [3137], '81-86Crossref': [3138], '(287)': [3141], 'PTEN': [3145], 'loss': [3146], '(16.Foo': [3147], 'W.C.': [3148], 'Rashid': [3149], 'Katz': [3153], 'M.H.': [3154], 'J.E.': [3156], 'Pisters': [3157], 'P.W.': [3158], 'Wolff': [3159], 'Abbruzzese': [3161], 'Loss': [3167], 'phosphatase': [3169], 'tensin': [3171], 'homolog': [3172], 'recurrence': [3177], 'adenocarcinoma.Human': [3186], 'Pathol.': [3187], '44:': [3189], '1024-1030Crossref': [3190], '(17)': [3193], 'However,': [3196], 'date,': [3198], 'candidate-based': [3210], 'studies,': [3211], 'unbiased,': [3214], 'malignancy': [3223], 'reported.': [3228], 'current': [3231], 'addressed': [3235], 'knowledge': [3237], 'gap': [3238], 'undertaking': [3240], 'MS-based': [3242], '(17.Hochgrafe': [3245], 'Zhang': [3247], "O'Toole": [3249], 'Browne': [3251], 'B.C.': [3252], 'Porta': [3255], 'Cubas': [3256], 'Lehrbach': [3258], 'Croucher': [3260], 'D.R.': [3261], 'Rickwood': [3262], 'Boulghourjian': [3264], 'Shearer': [3266], 'Nair': [3268], 'Swarbrick': [3270], 'Faratian': [3272], 'Mullen': [3274], 'Harrison': [3276], 'Raftery': [3282], 'Tyrosine': [3286], 'reveals': [3289], 'characteristics': [3293], 'Basal': [3295], 'breast': [3296], 'cells.Cancer': [3298], '70:': [3301], '9391-9401Crossref': [3302], '(146)': [3305], '18.Rikova': [3308], 'Guo': [3310], 'Zeng': [3312], 'Possemato': [3314], 'Yu': [3316], 'Haack': [3318], 'Nardone': [3320], 'Reeves': [3324], 'Li': [3326, 3354], 'Hu': [3328], 'Z.': [3331], 'Stokes': [3332], 'Sullivan': [3334], 'Mitchell': [3336], 'Wetzel': [3338], 'Macneill': [3340], 'Ren': [3342], 'J.M.': [3343, 3351], 'Yuan': [3344], 'Bakalarski': [3346], 'C.E.': [3347], 'Villen': [3348], 'Kornhauser': [3350], 'Zhou': [3356], 'X.': [3357], 'Gygi': [3358], 'T.L.': [3361], 'Polakiewicz': [3362], 'Rush': [3364], 'Comb': [3366], 'Global': [3368], 'identifies': [3373], 'oncogenic': [3374], 'lung': [3377], 'cancer.Cell.': [3378], '2007;': [3379], '131:': [3380], '1190-1203Abstract': [3381], '(1914)': [3389], 'large,': [3394], 'independent': [3395, 3843], 'cohorts,': [3399], 'revealing': [3400], 'subgroups': [3403], 'patterns,': [3409], 'networks,': [3411], 'erlotinib.': [3415], 'provides': [3422], 'important': [3423], 'highlights': [3429], 'help': [3433], 'guide': [3434], 'Two': [3439, 4017], 'cohorts': [3440], 'used.': [3447], 'Cohort': [3448, 3502, 4225, 4233], '(termed': [3452, 3506], 'Cohort)': [3455, 3509], 'purchased': [3457], 'authenticated': [3460], '(ATCC)': [3467], '(AsPC-1,': [3468], 'BxPC-3,': [3469], 'CFPAC-1,': [3470], 'Capan-1,': [3471], 'Capan-2,': [3472], 'HPAC,': [3473], 'HPAF-II,': [3474], 'Hs700T,': [3475], 'Hs766T,': [3476], 'Panc': [3477, 3479, 3481, 3484, 3486], '02.03,': [3478], '03.27,': [3480], '04.03,': [3482], 'Panc05.04,': [3483], '08.13,': [3485], '10.05,': [3487], 'Panc-1,': [3488], 'PL45,': [3489], 'MiaPaca-2,': [3490], 'SU.86.86,': [3491], 'SW1990)': [3492], 'cultured': [3497], 'according': [3498], 'protocols.': [3501], '2': [3503, 4246, 4339], 'isolated': [3511, 4418, 4532], 'patient-derived': [3514], 'house': [3520], '(TKCC': [3521, 3955, 4091], '2.1,': [3522], '04,': [3524], '05,': [3526], '06,': [3528], '07,': [3530], '09,': [3532], '10,': [3534], '12,': [3536], '14,': [3538], '15,': [3540], '16,': [3542], '17,': [3544], '18,': [3546], '19,': [3548], '22,': [3550], '26,': [3552], '27)': [3554], 'Animal': [3750, 3764], 'experimentation': [3751], 'generation': [3755], 'approved': [3757], 'Garvan': [3760], 'Institute/St': [3761], "Vincent's": [3762], 'Hospital': [3763], 'Ethics': [3765], 'Committee': [3766], '(approval': [3767], 'number:': [3768], 'ARA': [3769], '12/21).': [3770], 'conditions': [3772, 3823], 'summarized': [3775], 'supplemental': [3777], 'Table': [3778], 'S1.': [3779], 'Cells': [3780], 'plated,': [3782], 'allowed': [3783], 'reach': [3785], '∼70%': [3786], 'confluence,': [3787], 'placed': [3789], 'base': [3791], 'culture': [3792, 3822], 'medium,': [3793], 'without': [3794], 'serum': [3798], 'additional': [3800], 'factors,': [3802], '6': [3804, 3905], 'h': [3805, 3997], 'prior': [3806, 4028], 'lysate': [3808, 3965], 'collection.': [3809], 'undertaken': [3812], 'order': [3814], 'minimize': [3816], 'differences': [3817], 'comparison': [3826], 'inherent': [3829], 'properties': [3832], 'lines.': [3837], 'For': [3838, 4093, 4129, 4191, 4306, 4471], 'line,': [3841], 'biological': [3844], 'replicates': [3845], '∼2': [3847], '×': [3848], '108': [3849], 'cells': [3850, 3854, 3895], 'generated.': [3852], 'homogenized': [3856], '8': [3858], 'm': [3859, 3906], 'Urea': [3860], 'lysis': [3861, 3900], 'buffer': [3862, 3901, 4063, 4171], 'containing': [3863, 3909], '20': [3864, 3953], 'mm': [3865, 3870, 3874, 3878, 3886, 3911, 3930, 3970, 3978, 4065, 4071, 4076], 'HEPES': [3866], '(pH': [3867, 3913, 4067], '8),': [3868], '2.5': [3869, 4535], 'sodium': [3871, 3879, 4072, 4077], 'pyrophosphate,': [3872], 'β-glycerol': [3875], 'phosphate,': [3876], 'orthovanadate': [3880], 'reducing': [3883], 'agent': [3884], '(TCEP).': [3890], 'procedure': [3892], 'except': [3898], 'Guanidine': [3907], 'hydrochloride': [3908, 3972], '50': [3910, 3977], 'Tris-HCL': [3912], '8).': [3914], 'Samples': [3915, 4235], 'sonicated': [3917], 'ice,': [3919], 'cleared': [3920], 'centrifugation,': [3922], 'then': [3923, 4000, 4114], 'alkylated': [3924], '45': [3926], 'min': [3927], '4': [3929, 3996, 4123], 'iodoacetamide': [3931], '(in': [3932], 'dark)': [3934], 'room': [3936], '(RT).': [3938], 'lysates': [3940], 'subsequently': [3942], 'conduct': [3945], 'pTyr': [3946], 'profiling,': [3947], 'Western': [3951], 'blotting.': [3952], 'mg': [3954, 3959], 'panel)': [3956, 3961, 4086], '30': [3958], '(ATCC': [3960, 4085], 'diluted': [3967], 'guanidine': [3971], 'urea': [3974], 'respectively': [3975], 'ammonium': [3979], 'bicarbonate,': [3980], 'digested': [3982], '1:200': [3984], '(w/w)': [3985, 4003], 'Lysyl': [3987], 'Endopeptidase': [3988], '(WAKO': [3989], 'Chemicals,': [3990], 'Cape': [3991], 'Charles,': [3992], 'VA,': [3993], 'USA)': [3994, 4112, 4291], '(RT)': [3998, 4005], '1:100': [4002], 'overnight': [4004, 4056, 4121], 'TPCK': [4007], 'treated': [4008], 'trypsin': [4009], '(Worthington,': [4010], 'Lakewood,': [4011], 'NJ,': [4012], 'USA,': [4013], 'ratio': [4014], '1:100).': [4016], '"spike-in"': [4018], 'heavy': [4019], 'peptides': [4020, 4037, 4053, 4178, 4195, 4310, 4475], 'alanine': [4022], '(al)': [4023], 'C13N15': [4024], 'modifications': [4025], 'added': [4027], 'tC-18': [4030], 'clean-up': [4031], '(Waters,': [4032], 'Milford,': [4033], 'MA,': [4034, 4111, 4211], 'USA).': [4035, 4159], 'EF1A1': [4039], '(EHA(al)LLApYTLGVK)': [4040], '(500': [4041], 'fM)': [4042], 'MAPK14': [4044], '(HTDDEMTGpYVA(al)TR)': [4045], '(50': [4046, 4064], 'pm)': [4047], '(Mimotopes,': [4048], 'Nottinghill,': [4049], 'Vic,': [4050], 'Aus).': [4051], 'Purified': [4052, 4148], 'lyophilized': [4055], 'dissolved': [4058, 4194], '(IAP)': [4062], 'MOPS': [4066], '7.4)': [4068], '10': [4070, 4517], 'phosphate': [4073], 'dibasic,': [4074], '130': [4075], 'chloride': [4078], 'either': [4080], '0.5%': [4081], '(v/v)': [4082, 4089, 4183, 4189, 4323], 'Nonidet': [4083], 'P-40': [4084], '1%': [4088], 'n-octyl-b-d-glucopyranoside': [4090], 'panel)).': [4092], 'panel,': [4096, 4132], 'Sepharose': [4097], '4B': [4098], 'beads': [4099], 'pre-conjugated': [4100], '100': [4102, 4255, 4431], 'μg': [4103, 4146], 'PY100': [4105, 4137], 'antibody': [4106, 4120, 4152], '(Cell': [4107], 'Signaling': [4108], 'Technology,': [4109], 'Danvers,': [4110], 'added.': [4115], 'Peptides': [4116, 4160], 'incubated': [4118], '°C': [4124], 'rotating': [4127], 'apparatus.': [4128], 'flowthrough': [4134], 'IP': [4138], 'collected': [4140], 'immunoprecipitated': [4142], 'again': [4143], '150': [4145], 'Mouse': [4149], 'Anti-Phosphotyrosine': [4150], '(pY20)': [4151], '(BD': [4153], 'Transduction': [4154], 'Labs,': [4155], 'San': [4156], 'Jose,': [4157], 'CA,': [4158, 4290], 'nonspecific': [4162], 'binding': [4163], 'removed': [4165], 'washes': [4168, 4174], 'IAP': [4170], 'dH2O.': [4176], 'Bound': [4177], 'eluted': [4180, 4312], '0.15%': [4182], '(TFA)': [4186], '40%': [4188], 'acetonitrile.': [4190], 'MS': [4192, 4481], 'analyses,': [4193], 'separated': [4197, 4263], 'nano-LC': [4199], 'Ultimate': [4202, 4302], '3000': [4203, 4303], 'HPLC': [4204], 'autosampler': [4206], 'system': [4207], '(Thermo': [4208], 'Scientific,': [4209], 'Waltham,': [4210], 'USA),': [4212], 'spectra': [4215, 4444], 'acquired': [4217, 4376, 4446, 4499], 'Q': [4219, 4308], 'Exactive': [4220], 'Plus': [4221], 'samples': [4226], 'Orbitrap': [4228, 4449, 4473], 'Velos': [4229], 'samples.': [4234], 'desalted': [4237], 'loading': [4239], 'onto': [4240], 'C18': [4242, 4294], 'pre-column': [4243], '(100': [4244], 'μm,': [4245], 'cm': [4247, 4267], 'column;': [4248], 'particle': [4249], 'size': [4250, 4254], '5': [4251, 4279, 4344], 'μm;': [4252], 'pore': [4253], 'Å;': [4256], 'Acclaim': [4257], 'PepMap': [4258], 'RSLC,': [4259], 'Thermo': [4260, 4357], 'Scientific),': [4261], '12': [4266, 4398], '75': [4268], 'μm': [4269, 4280], 'ID': [4270], 'analytical': [4271], 'column': [4272], 'pulled': [4273], 'internal': [4276], 'diameter': [4277], 'P-2000': [4283], 'laser': [4284], 'puller': [4285], '(Sutter': [4286], 'Instruments': [4287], 'Co,': [4288], 'Novato,': [4289], 'packed': [4292], 'Magic': [4295], 'reverse': [4296], 'phase': [4297], 'material,': [4298], 'Dionex': [4301], 'LC': [4304], 'system.': [4305], 'Exactive,': [4309], '250': [4314], 'nL/min': [4315], 'gradient': [4318], 'acetonitrile': [4320], '0.1%': [4322], 'aqueous': [4324], 'formic': [4325], 'follows:': [4328], '2–10%': [4329], 'min,': [4332, 4336, 4340], '10–26%': [4333], '27': [4335], '26–34%': [4337], '34–80%': [4342], 'min.': [4345], 'eluent': [4347], 'directed': [4349], 'nano-electrospray': [4352], 'ion': [4353], 'source': [4354], '(Nanospray': [4355], 'Flex,': [4356], 'Scientific)': [4358], 'spray': [4361, 4484], 'voltage': [4362, 4485], '1.7': [4364], 'kV.': [4365], 'Survey': [4366], 'scans': [4367, 4490], 'range': [4371, 4494], '375–1600': [4373], 'm/z': [4374, 4383, 4458, 4497, 4506], '70,000': [4381], '200': [4384, 4459], 'AGC': [4387, 4510], 'target': [4388, 4425, 4511, 4539], '3e6': [4390], 'ions': [4391, 4401, 4428, 4461, 4520, 4542], '(max': [4392, 4429], 'IIT': [4393, 4430], '120': [4394], 'ms).': [4395], 'top': [4397, 4516], 'intense': [4400, 4519], '(ion': [4402, 4521], 'selection': [4403, 4465, 4522], 'threshold': [4404, 4523], '1000': [4406], 'ions,': [4407, 4526], 'charge': [4408, 4527], 'state': [4409, 4528], '2–5,': [4410], 'preferred': [4411], 'peptide': [4412], 'match,': [4413], 'exclude': [4414], 'isotopes)': [4415], 'sequentially': [4417, 4531], '(isolation': [4419, 4533], 'window': [4420, 4534], '1.8': [4421, 4487], 'm/z)': [4422, 4536], '1e5': [4427, 4541], 'ms),': [4432], 'fragmented': [4434, 4544], 'HCD': [4437], '(normalized': [4439], 'collision': [4440], 'energy': [4441], '27).': [4442], 'MS/MS': [4443], 'analyzer': [4451], '17,500': [4456], 'excluded': [4463], 'further': [4468], '15': [4469], 's.': [4470], 'Velos,': [4474], 'electrosprayed': [4477], 'directly': [4478], 'kV,': [4488], '350–1750': [4496], '60,000': [4504], '400': [4507], '1e6': [4513], 'ions.': [4514], '500': [4525], '≥2)': [4529]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2411389177', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2025-01-07T18:12:01.303584', 'created_date': '2016-06-24'}