Title: [Transcriptional regulation by CREB and proteins of CREB family].
Abstract: CREB (cAMP-responsive element binding protein), which can be activated after phosphorylation by protein kinase A, plays an important role in cAMP-induced gene expression. Several recent studies have suggested that a co-activator designated as CREB binding protein (CBP) is crucial in mediating the transcriptional activity of CREB. In nervous system, in addition to playing a role in neurotransmitter-induced gene transcription, CREB may take part in mediating neurotrophin signals that ultimately lead to such cellular responses as proliferation, differentiation and survival.
Publication Year: 1996
Publication Date: 1996-07-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 3
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