Title: Recent progress on miRNAs in the pathogenesis of colon cancer
Abstract: microRNAs(miRNAs)are endogenous,small noncoding RNA molecules discovered in animals, plants and virHse.They play a critical role in developmental and physiological processes and are implicated in the patho genesis of many human cancers.Presently,human cancer,including colorectal cancer,is recognized as both a genetic and epigenefic disease.Changes induced by miRNAs are considered as epigenetic changes.Experiments were largely performed to analyze the colorectal microRNAome and bio-networking involving miRNAs.This review focuses on recent advanccs in colorectal miRNA expression profiles.Further,we discuss the regulatory network of miRNAs in the inifiation and carcinogenesis of colon cancer in order to open up an avenue of anticancer therapy based on the epigenetic regulation by miRNAs.
Key words:
micmRNA; colorectal cancer; epigenesis
Publication Year: 2008
Publication Date: 2008-06-01
Language: en
Type: article
Indexed In: ['pubmed']
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