Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2410975151', 'doi': None, 'title': 'Anti-inflammatory effect of methanolic extract of Conyzacanadensis in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophage cells.', 'display_name': 'Anti-inflammatory effect of methanolic extract of Conyzacanadensis in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophage cells.', 'publication_year': 2016, 'publication_date': '2016-05-01', 'ids': {'openalex': 'https://openalex.org/W2410975151', 'mag': '2410975151', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27166556'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27166556', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061920579', 'display_name': 'Jia‐Le Song', 'orcid': 'https://orcid.org/0000-0001-6269-5846'}, 'institutions': [{'id': 'https://openalex.org/I176134282', 'display_name': 'Guilin Medical University', 'ror': 'https://ror.org/000prga03', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I176134282']}, {'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['CN', 'KR'], 'is_corresponding': False, 'raw_author_name': 'Jia-Le Song', 'raw_affiliation_strings': ["Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, Guangxi, People's Republic of China / Department of Food Science and Nutrition, Pusan National University, Busan, South Korea."], 'affiliations': [{'raw_affiliation_string': "Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, Guangxi, People's Republic of China / Department of Food Science and Nutrition, Pusan National University, Busan, South Korea.", 'institution_ids': ['https://openalex.org/I176134282', 'https://openalex.org/I4921948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011785508', 'display_name': 'Ruokun Yi', 'orcid': 'https://orcid.org/0000-0002-5585-6717'}, 'institutions': [{'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ruo-Kun Yi', 'raw_affiliation_strings': ['Department of Food Science and Nutrition Pusan National University Busan South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Food Science and Nutrition Pusan National University Busan South Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052243820', 'display_name': 'Yang Gao', 'orcid': 'https://orcid.org/0000-0001-6357-7470'}, 'institutions': [{'id': 'https://openalex.org/I4210137355', 'display_name': "Northern Jiangsu People's Hospital", 'ror': 'https://ror.org/04gz17b59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137355']}, {'id': 'https://openalex.org/I78978612', 'display_name': 'Yangzhou University', 'ror': 'https://ror.org/03tqb8s11', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I78978612']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Gao', 'raw_affiliation_strings': ["Department of Pharmacy, Northern Jiangsu People's Hospital Affiliated to Yangzhou University (Clinical Medical College of Yangzhou University), Yangzhou, Jiangsu, People's Republic of China."], 'affiliations': [{'raw_affiliation_string': "Department of Pharmacy, Northern Jiangsu People's Hospital Affiliated to Yangzhou University (Clinical Medical College of Yangzhou University), Yangzhou, Jiangsu, People's Republic of China.", 'institution_ids': ['https://openalex.org/I4210137355', 'https://openalex.org/I78978612']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.124, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.528678, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 80}, 'biblio': {'volume': '29', 'issue': '3', 'first_page': '935', 'last_page': '40'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11385', 'display_name': 'Biological Activities of Triterpenoids and Saponins', 'score': 0.9819, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11385', 'display_name': 'Biological Activities of Triterpenoids and Saponins', 'score': 0.9819, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11613', 'display_name': 'Medicinal Plants: Chemical Constituents and Biological Activities', 'score': 0.9799, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13792', 'display_name': 'Therapeutic Properties of Morinda citrifolia', 'score': 0.9716, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anti-inflammatory', 'display_name': 'Anti-inflammatory', 'score': 0.518503}], 'concepts': [{'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.88116854}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.8223739}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.7689604}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.71465194}, {'id': 'https://openalex.org/C2777956040', 'wikidata': 'https://www.wikidata.org/wiki/Q416554', 'display_name': 'Prostaglandin E2', 'level': 2, 'score': 0.690041}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.6344168}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.59013534}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.5519351}, {'id': 'https://openalex.org/C2779689624', 'wikidata': 'https://www.wikidata.org/wiki/Q410251', 'display_name': 'Cyclooxygenase', 'level': 3, 'score': 0.47050306}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.41588035}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40164128}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3491363}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.30314058}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.29195496}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.267005}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.25881654}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19498786}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.1614826}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.15311262}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000432', 'descriptor_name': 'Methanol', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D012997', 'descriptor_name': 'Solvents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005591', 'descriptor_name': 'Chemical Fractionation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000432', 'descriptor_name': 'Methanol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008517', 'descriptor_name': 'Phytotherapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000067996', 'descriptor_name': 'RAW 264.7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012997', 'descriptor_name': 'Solvents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27166556', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.44}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3178871832', 'https://openalex.org/W2978537570', 'https://openalex.org/W2800313057', 'https://openalex.org/W2410975151', 'https://openalex.org/W2269603625', 'https://openalex.org/W2174181978', 'https://openalex.org/W2146503628', 'https://openalex.org/W2098857326', 'https://openalex.org/W2051267793', 'https://openalex.org/W1986259368'], 'abstract_inverted_index': {'The': [0], 'aim': [1], 'of': [2, 12, 21, 38, 46, 69, 98, 110], 'this': [3], 'study': [4], 'was': [5, 40], 'to': [6], 'investigate': [7], 'the': [8, 43, 66, 95, 108], 'potential': [9], 'anti-inflammatory': [10, 91], 'effect': [11], 'Conyzacanadeusis': [13], 'methanol': [14], 'extract': [15], '(CME)': [16], 'using': [17], 'a': [18], 'cell': [19, 25], 'model': [20], 'RAW264.7': [22, 82, 118], 'murine': [23], 'macrophage': [24], 'stimulated': [26], 'with': [27, 31], 'lipopolysaccharide': [28], '(LPS)(1μg/ml).': [29], 'Co-treatment': [30], 'different': [32], 'concentrations': [33], '(10,': [34], '50': [35], 'and': [36, 59, 78, 103, 105, 115], '100μg/ml)': [37], 'CME': [39, 63, 88], 'concentration-dependently': [41], 'reduced': [42, 65, 94], 'LPS-induced': [44], 'generation': [45], 'prostaglandin': [47], 'E2': [48], '(PGE2),': [49], 'nitric': [50, 73], 'oxide': [51, 74], '(NO)': [52], 'tumor': [53], 'necrosis': [54], 'factor-α': [55], '(TNF-α),': [56], 'interleukin': [57], '(IL)-1β': [58], 'IL-6.': [60], 'In': [61], 'addition,': [62], 'also': [64, 106], 'mRNA': [67, 96], 'expressions': [68], 'cyclooxygenase-2': [70], '(COX-2),': [71], 'inducible': [72], '(iNOS),': [75], 'TNF-α,': [76], 'IL-1β': [77, 102, 114], 'IL-6': [79, 104], 'in': [80], 'LPS-stimulated': [81, 117], 'cells.': [83, 119], 'These': [84], 'results': [85], 'suggested': [86], 'that': [87], 'showed': [89], 'an': [90], 'activity': [92], 'through': [93], 'expression': [97], 'COX-2,': [99], 'iNOS,': [100], 'TNF-α': [101, 113], 'decreased': [107], 'productions': [109], 'PGE2,': [111], 'NO,': [112], 'IL-6in': [116]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2410975151', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-08-21T12:59:14.867022', 'created_date': '2016-06-24'}