Title: Antagonistic action of anti-androgens on the formation of a specific dihydrotestosterone-receptor protein complex in rat ventral prostate.
Abstract: Cyproterone (1,2α-methylene-6-chloro-Δ4,6-pregnadien-17α-ol-3,20-dione) 17α-acetate, a potent anti-androgen, suppressed the uptake of radioactive androgens in vivo by the ventral prostate of rats. This was accompanied by a decrease in the retention of 5α-dihydrotestosterone (17β-hydroxy-5α-androstan-3-one) by prostate cell nuclei . Cyproterone and its 17α-acetate (less than 0.5 µg/ml) also inhibited the formation of a specific dihydrotestosterone-protein complex in prostate cell nuclei when minced prostate was incubated with radioactive testosterone or dihydrotestosterone. Estradiol-17β, diethylstilbestrol, and progesterone, but not hydrocortisone succinate, also suppressed the retention of dihydrotestosterone by prostatic cell nuclei in vitro, but to a much lesser extent than cyproterone.
Publication Year: 1969
Publication Date: 1969-07-01
Language: en
Type: article
Indexed In: ['pubmed']
Access and Citation
Cited By Count: 108
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