Title: 61 Hypoxia-Inducible Factor 1 (HIF-1) Transcription is a “Signalling Driver” for Allergic Inflammation, Host Innate Immune Defence and Leukaemia Progression
Abstract:Background
Hypoxia-inducible factor 1 is a transcription complex that plays a pivotal role in cellular adaptation to low oxygen availability, which occurs during allergic responses, host immune defen...Background
Hypoxia-inducible factor 1 is a transcription complex that plays a pivotal role in cellular adaptation to low oxygen availability, which occurs during allergic responses, host immune defence and leukaemia progression. We investigated the role of HIF-1 in cellular adaptation to stress associated with different types of pathological reactions of immune cells. We studied IgE-dependent responses of human mast cells and basophils, Toll-like receptor (TLR)-mediated innate immune reactions of human myeloid cells and stem cell factor (SCF)-mediated responses of hematopoietic cells of myeloid lineage.Read More