Publication Information

{'id': 'https://openalex.org/W2409657626', 'doi': 'https://doi.org/10.1007/s00345-016-1868-5', 'title': 'Systemic therapy in metastatic renal cell carcinoma', 'display_name': 'Systemic therapy in metastatic renal cell carcinoma', 'publication_year': 2016, 'publication_date': '2016-06-09', 'ids': {'openalex': 'https://openalex.org/W2409657626', 'doi': 'https://doi.org/10.1007/s00345-016-1868-5', 'mag': '2409657626', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27277600', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5272893'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00345-016-1868-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00345-016-1868-5.pdf', 'source': {'id': 'https://openalex.org/S49004918', 'display_name': 'World Journal of Urology', 'issn_l': '0724-4983', 'issn': ['0724-4983', '1433-8726'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s00345-016-1868-5.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080116321', 'display_name': 'Jens Bedke', 'orcid': 'https://orcid.org/0000-0003-2778-3108'}, 'institutions': [{'id': 'https://openalex.org/I8087733', 'display_name': 'University of Tübingen', 'ror': 'https://ror.org/03a1kwz48', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8087733']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Jens Bedke', 'raw_affiliation_strings': ['Department of Urology, Eberhard Karls University Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Eberhard Karls University Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany', 'institution_ids': ['https://openalex.org/I8087733']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047006205', 'display_name': 'Thomas Gauler', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Gauler', 'raw_affiliation_strings': ['Department of Radiation Oncology, University of Essen, Essen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, University of Essen, Essen, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001987856', 'display_name': 'Viktor Grünwald', 'orcid': 'https://orcid.org/0000-0003-2083-7687'}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Viktor Grünwald', 'raw_affiliation_strings': ['Department of Hematology and Oncology, Medical School Hannover, Hannover, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Oncology, Medical School Hannover, Hannover, Germany', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112738888', 'display_name': 'Axel Hegele', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161103922', 'display_name': 'Philipps University of Marburg', 'ror': 'https://ror.org/01rdrb571', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161103922']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Axel Hegele', 'raw_affiliation_strings': ['Department of Urology and Pediatric Urology, University of Marburg, Marburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology and Pediatric Urology, University of Marburg, Marburg, Germany', 'institution_ids': ['https://openalex.org/I161103922']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103385944', 'display_name': 'Edwin Herrmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Edwin Herrmann', 'raw_affiliation_strings': ['Department of Urology, University of Münster, Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, University of Münster, Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048386880', 'display_name': 'Stefan Hinz', 'orcid': 'https://orcid.org/0000-0003-3184-2983'}, 'institutions': [{'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stefan Hinz', 'raw_affiliation_strings': ['Department of Urology, Charité Universitaetsmedizin Berlin, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Charité Universitaetsmedizin Berlin, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006956385', 'display_name': 'Jan Janssen', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jan Janssen', 'raw_affiliation_strings': ['Onkologie Westerstede, Westerstede, Germany'], 'affiliations': [{'raw_affiliation_string': 'Onkologie Westerstede, Westerstede, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110483044', 'display_name': 'Stephan Schmitz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139683', 'display_name': 'Praxis für Hämatologie und Onkologie', 'ror': 'https://ror.org/03wgek846', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139683']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stephan Schmitz', 'raw_affiliation_strings': ['Gemeinschaftspraxis für Onkologie und Hämatologie, Köln, Germany'], 'affiliations': [{'raw_affiliation_string': 'Gemeinschaftspraxis für Onkologie und Hämatologie, Köln, Germany', 'institution_ids': ['https://openalex.org/I4210139683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079462263', 'display_name': 'Martin Schostak', 'orcid': 'https://orcid.org/0000-0002-8717-2096'}, 'institutions': [{'id': 'https://openalex.org/I4210138551', 'display_name': 'University Hospital Magdeburg', 'ror': 'https://ror.org/03m04df46', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210138551']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Martin Schostak', 'raw_affiliation_strings': ['Department of Urology, University of Magdeburg, Magdeburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, University of Magdeburg, Magdeburg, Germany', 'institution_ids': ['https://openalex.org/I4210138551']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072762948', 'display_name': 'Hans Tesch', 'orcid': 'https://orcid.org/0000-0001-7839-4917'}, 'institutions': [{'id': 'https://openalex.org/I4210089193', 'display_name': 'Cardiovascular Center Bethanien', 'ror': 'https://ror.org/00bypm595', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210089193']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hans Tesch', 'raw_affiliation_strings': ['Onkologie Bethanien, Frankfurt am Main, Germany'], 'affiliations': [{'raw_affiliation_string': 'Onkologie Bethanien, Frankfurt am Main, Germany', 'institution_ids': ['https://openalex.org/I4210089193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046265390', 'display_name': 'Stefan Zastrow', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stefan Zastrow', 'raw_affiliation_strings': ['Department of Urology, Technical University of Dresden, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Technical University of Dresden, Dresden, Germany', 'institution_ids': ['https://openalex.org/I78650965']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110049408', 'display_name': 'Kurt Miller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Kurt Miller', 'raw_affiliation_strings': ['Department of Urology, Charité Universitaetsmedizin Berlin, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Charité Universitaetsmedizin Berlin, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 9, 'corresponding_author_ids': ['https://openalex.org/A5080116321'], 'corresponding_institution_ids': ['https://openalex.org/I8087733'], 'apc_list': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'apc_paid': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'fwci': 5.286, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 204, 'citation_normalized_percentile': {'value': 0.99959, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '35', 'issue': '2', 'first_page': '179', 'last_page': '188'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10449', 'display_name': 'Renal cell carcinoma treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10449', 'display_name': 'Renal cell carcinoma treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9901, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/temsirolimus', 'display_name': 'Temsirolimus', 'score': 0.9225286}, {'id': 'https://openalex.org/keywords/pazopanib', 'display_name': 'Pazopanib', 'score': 0.8863126}, {'id': 'https://openalex.org/keywords/everolimus', 'display_name': 'Everolimus', 'score': 0.8404273}, {'id': 'https://openalex.org/keywords/axitinib', 'display_name': 'Axitinib', 'score': 0.67737395}, {'id': 'https://openalex.org/keywords/targeted-therapy', 'display_name': 'Targeted Therapy', 'score': 0.43981856}], 'concepts': [{'id': 'https://openalex.org/C2776820818', 'wikidata': 'https://www.wikidata.org/wiki/Q7699074', 'display_name': 'Temsirolimus', 'level': 5, 'score': 0.9225286}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.89860976}, {'id': 'https://openalex.org/C2778439243', 'wikidata': 'https://www.wikidata.org/wiki/Q7157043', 'display_name': 'Pazopanib', 'level': 4, 'score': 0.8863126}, {'id': 'https://openalex.org/C2779699572', 'wikidata': 'https://www.wikidata.org/wiki/Q421052', 'display_name': 'Everolimus', 'level': 2, 'score': 0.8404273}, {'id': 'https://openalex.org/C2779490328', 'wikidata': 'https://www.wikidata.org/wiki/Q417542', 'display_name': 'Sunitinib', 'level': 3, 'score': 0.8208853}, {'id': 'https://openalex.org/C2778695046', 'wikidata': 'https://www.wikidata.org/wiki/Q421136', 'display_name': 'Sorafenib', 'level': 3, 'score': 0.7647501}, {'id': 'https://openalex.org/C2776539811', 'wikidata': 'https://www.wikidata.org/wiki/Q4830631', 'display_name': 'Axitinib', 'level': 4, 'score': 0.67737395}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.6444539}, {'id': 'https://openalex.org/C2780030458', 'wikidata': 'https://www.wikidata.org/wiki/Q7041828', 'display_name': 'Nivolumab', 'level': 4, 'score': 0.641773}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5901351}, {'id': 'https://openalex.org/C2777472916', 'wikidata': 'https://www.wikidata.org/wiki/Q1164529', 'display_name': 'Renal cell carcinoma', 'level': 2, 'score': 0.5021987}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.46665975}, {'id': 'https://openalex.org/C2781230642', 'wikidata': 'https://www.wikidata.org/wiki/Q492646', 'display_name': 'Targeted therapy', 'level': 3, 'score': 0.43981856}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.3754589}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.3088476}, {'id': 'https://openalex.org/C183713625', 'wikidata': 'https://www.wikidata.org/wiki/Q5282002', 'display_name': 'Discovery and development of mTOR inhibitors', 'level': 4, 'score': 0.24190348}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.23031417}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.09591529}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077784', 'descriptor_name': 'Axitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003663', 'descriptor_name': 'Decision Trees', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068338', 'descriptor_name': 'Everolimus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068338', 'descriptor_name': 'Everolimus', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007191', 'descriptor_name': 'Indazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007191', 'descriptor_name': 'Indazoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D009536', 'descriptor_name': 'Niacinamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009536', 'descriptor_name': 'Niacinamide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D009536', 'descriptor_name': 'Niacinamide', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D000077594', 'descriptor_name': 'Nivolumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010671', 'descriptor_name': 'Phenylurea Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010671', 'descriptor_name': 'Phenylurea Compounds', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D000077157', 'descriptor_name': 'Sorafenib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000077210', 'descriptor_name': 'Sunitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00345-016-1868-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00345-016-1868-5.pdf', 'source': {'id': 'https://openalex.org/S49004918', 'display_name': 'World Journal of Urology', 'issn_l': '0724-4983', 'issn': ['0724-4983', '1433-8726'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5272893', 'pdf_url': 'https://europepmc.org/articles/pmc5272893?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44129', 'pdf_url': 'http://publikationen.ub.uni-frankfurt.de/files/44129/345_2016_Article_1868.pdf', 'source': {'id': 'https://openalex.org/S4306400432', 'display_name': 'Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I114090438', 'host_organization_name': 'Goethe University Frankfurt', 'host_organization_lineage': ['https://openalex.org/I114090438'], 'host_organization_lineage_names': ['Goethe University Frankfurt'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272893', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27277600', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00345-016-1868-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00345-016-1868-5.pdf', 'source': {'id': 'https://openalex.org/S49004918', 'display_name': 'World Journal of Urology', 'issn_l': '0724-4983', 'issn': ['0724-4983', '1433-8726'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.79, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320332736', 'funder_display_name': 'Novartis Pharma', 'award_id': 'educational grant'}], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1544119899', 'https://openalex.org/W1717153315', 'https://openalex.org/W1767959606', 'https://openalex.org/W1852876364', 'https://openalex.org/W1970465313', 'https://openalex.org/W2023952988', 'https://openalex.org/W2029905169', 'https://openalex.org/W2036434473', 'https://openalex.org/W2037716205', 'https://openalex.org/W2040473030', 'https://openalex.org/W2046507292', 'https://openalex.org/W2047871200', 'https://openalex.org/W2057394313', 'https://openalex.org/W2058736678', 'https://openalex.org/W2066604995', 'https://openalex.org/W2071794510', 'https://openalex.org/W2099088585', 'https://openalex.org/W2100669312', 'https://openalex.org/W2116949558', 'https://openalex.org/W2118677643', 'https://openalex.org/W2123826780', 'https://openalex.org/W2127385754', 'https://openalex.org/W2131818083', 'https://openalex.org/W2138129102', 'https://openalex.org/W2140116071', 'https://openalex.org/W2149456801', 'https://openalex.org/W2153867442', 'https://openalex.org/W2158082603', 'https://openalex.org/W2160476851', 'https://openalex.org/W2160724351', 'https://openalex.org/W2162424705', 'https://openalex.org/W2164317031', 'https://openalex.org/W2222086386', 'https://openalex.org/W2237254160', 'https://openalex.org/W2316731546', 'https://openalex.org/W2335012284', 'https://openalex.org/W2513946864', 'https://openalex.org/W2514514995', 'https://openalex.org/W2589691326', 'https://openalex.org/W2589722562', 'https://openalex.org/W2616462236'], 'related_works': ['https://openalex.org/W4380896460', 'https://openalex.org/W4286959671', 'https://openalex.org/W4214919057', 'https://openalex.org/W3013397008', 'https://openalex.org/W2809235123', 'https://openalex.org/W2598164697', 'https://openalex.org/W2590180656', 'https://openalex.org/W2540734518', 'https://openalex.org/W2254527377', 'https://openalex.org/W2057068676'], 'abstract_inverted_index': {'Current': [0], 'systemic': [1], 'treatment': [2, 56, 84, 124, 130, 203], 'of': [3, 22, 44, 57, 74, 79, 138, 146, 167, 189, 197, 231], 'targeted': [4], 'therapies,': [5, 172], 'namely': [6], 'the': [7, 72, 122, 178, 187, 194, 219], 'vascular': [8], 'endothelial': [9], 'growth': [10], 'factor-antibody': [11], '(VEGF-AB),': [12], 'VEGF': [13], 'receptor': [14], 'tyrosine': [15], 'kinase': [16], 'inhibitor': [17, 182], '(TKI)': [18], 'and': [19, 30, 82, 89, 140, 148, 201], 'mammalian': [20], 'target': [21], 'rapamycin': [23], '(mTOR)': [24], 'inhibitors,': [25], 'have': [26], 'improved': [27, 158], 'progression-free': [28], 'survival': [29, 160], 'replaced': [31], 'non-specific': [32], 'immunotherapy': [33], 'with': [34, 85, 99, 116, 218], 'cytokines': [35], 'in': [36, 60, 94, 114, 183, 204, 223], 'metastatic': [37], 'renal': [38], 'cell': [39, 104, 118], 'carcinoma': [40], '(mRCC).': [41], 'A': [42], 'panel': [43], 'experts': [45], 'convened': [46], 'to': [47, 62, 163, 176], 'review': [48, 70], 'currently': [49], 'available': [50, 63], 'phase': [51], '3': [52], 'data': [53, 66, 206], 'for': [54, 67, 97, 186, 199, 207], 'mRCC': [55], 'approved': [58, 92], 'agents,': [59], 'addition': [61], 'EAU': [64], 'guideline': [65], 'a': [68, 152, 228], 'collaborative': [69], 'as': [71], 'plurality': [73], 'substances': [75], 'offers': [76], 'different': [77], 'options': [78, 133, 144], 'first-,': [80], 'second-': [81], 'third-line': [83, 143, 208], 'potential': [86], 'sequencing.': [87], 'Sunitinib': [88], 'pazopanib': [90], 'are': [91, 129, 210], 'treatments': [93], 'first-line': [95], 'therapy': [96, 209], 'patients': [98, 115], 'favorable-': [100], 'or': [101, 126, 169, 216], 'intermediate-risk': [102], 'clear': [103], 'RCC': [105, 119], '(ccRCC).': [106], 'Temsirolimus': [107], 'has': [108], 'proven': [109], 'benefit': [110, 161], 'over': [111], 'interferon-alfa': [112], '(IFN-α)': [113], 'non-clear': [117], '(non-ccRCC).': [120], 'In': [121], 'second-line': [123, 202], 'TKIs': [125], 'mTOR': [127], 'inhibitors': [128, 222], 'choices.': [131], 'Therapy': [132], 'after': [134, 165, 233], 'TKI': [135, 235], 'failure': [136, 166], 'consist': [137, 145], 'everolimus': [139, 147, 164], 'axitinib.': [141], 'Available': [142], 'sorafenib.': [149], 'Recently,': [150], 'nivolumab,': [151], 'programmed': [153], 'death-1': [154], '(PD1)': [155], 'checkpoint': [156, 181, 221], 'inhibitor,': [157], 'overall': [159], 'compared': [162], 'one': [168], 'two': [170], 'VEGFR-targeted': [171], 'which': [173, 225], 'is': [174], 'likely': [175], 'become': [177], 'first': [179, 200], 'established': [180], 'mRCC.': [184], 'Data': [185], 'sequencing': [188], 'agents': [190], 'remain': [191], 'limited.': [192, 211], 'Despite': [193], 'high': [195], 'level': [196], 'evidence': [198], 'mRCC,': [205], 'Possible': [212], 'sequences': [213], 'include': [214], 'TKI-mTOR-TKI': [215], 'TKI–TKI-mTOR': [217], 'upcoming': [220], 'perspective,': [224], 'might': [226], 'settle': [227], 'new': [229], 'standard': [230], 'care': [232], 'previous': [234], 'therapy.': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2409657626', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 30}, {'year': 2022, 'cited_by_count': 24}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 27}, {'year': 2019, 'cited_by_count': 30}, {'year': 2018, 'cited_by_count': 32}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-29T11:18:07.701860', 'created_date': '2016-06-24'}