Abstract: Much of the remarkable advance in our understanding of the immunopathology of MG relates to the availability of two gifts of nature that permit the ready purification of the antigen, AChR. Immunization of experimental animals with AChR has led to the development of the extremely faithful animal model, EAMG. The pathogenic effects on neuromuscular transmission in myasthenia gravis and experimental autoimmune myasthenia gravis are mediated by antibody-induced antigenic modulation of end plate AChR, end plate membrane destruction through complement fixation and recruitment of inflammatory cells, and antibody-induced blockade of the function of the remaining AChR molecules.
Publication Year: 1994
Publication Date: 1994-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 21
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