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[5], '(以下DLBと略す)': [6], 'は,': [7], '1976年以降の筆者らの一連の研究により注目され,': [8], '筆者らにより提唱された「Lewy': [9], '小体病」Lewy': [10], 'body': [11, 17], 'disease': [12, 18], 'やその一型である「びまん性': [13], '小体病」diffuse': [15], 'を基礎として,': [19], '1995年の第一回国際ワークショップで提唱された名称である.': [20], 'そのワークショップの報告が1996年にCDLBガイドラインとしてまとめられ,': [21], 'そこで臨床および病理診断基準が提唱された.': [22], 'これにより臨床診断が可能になり,': [23], 'DLBは臨床家の間でもよく知られるようになり,': [24], '現在では頻度が高いことから,': [25], 'アルツハイマー型痴呆,': [26], '血管性痴呆とともに三大痴呆疾患と討われている.その後,': [27], '1998年に第2回国際ワークショップが,': [28], '2003年に第3回国際ワークショップが開催され,': [29], 'また,DLBに関する臨床的・病理学的・生化学的・分子遺伝学的研究が進展し,': [30], '新しい知見が加わってきている.近いうちに,': [31], '改訂版CDLBガイドラインが報告されることになっているが,': [32], '小体の主要な構成成分としてα-synuclein': [34], 'が明らかになり,': [35], 'その免疫染色により': [36], '小体や': [38], '神経突起が容易に見い出されるようになり,': [40], '病理診断も容易になった.': [41], 'また,': [42], 'DLBでは脳内のアセチルコリン濃度がアルツハイマー型痴呆よりも少ないことから,': [43], 'コリンエステラーゼ阻害薬がより効果的であることも明らかにされ,': [44], 'また家族例でのα-synuclein': [45], '遺伝子異常も明らかになりつつあり,': [46], 'DLBがますます注目されるようになった.': [47], 'ここでは,': [48], '筆者らの研究を中心に紹介し,': [49], 'DLBの研究の進歩について概説する.': [50]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2409514309', 'counts_by_year': [], 'updated_date': '2024-08-21T01:58:47.786082', 'created_date': '2016-06-24'}