Title: Deterioration in premorbid functioning in schizophrenia: a developmental model of negative symptoms in drug-free patients
Abstract: Back to table of contents Previous article Next article No AccessDeterioration in premorbid functioning in schizophrenia: a developmental model of negative symptoms in drug-free patientsPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.149.11.1543AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors examined the relationship between negative symptoms and premorbid variables in drug-free schizophrenic patients. METHOD: The authors studied 63 clinically stable male schizophrenic inpatients who were not receiving any psychoactive medication. The patients were classified as having negative, positive, or mixed symptoms, and their premorbid functioning during childhood, early adolescence, and late adolescence was assessed by using the Premorbid Adjustment Scale. Correlational analyses were applied to the classification and developmental models. RESULTS: Patients with negative symptoms had significantly lower levels of premorbid functioning during late adolescence and significantly greater premorbid deterioration between childhood and early adolescence. Correlational analysis revealed significant positive relationships between premorbid variables and negative symptoms. CONCLUSIONS: The data suggest that a deterioration in social and intellectual functioning between childhood and adolescence is associated with the development of a negative symptom syndrome in schizophrenia. The premorbid deterioration appears to be an early prodrome of the disorder. Whether this residual negative symptom syndrome is in some way related to the deficit syndrome of schizophrenia awaits a prospective study. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byNegative Symptoms and Functioning in Youth at Risk of Psychosis: A Systematic Review and Meta-analysisHarvard Review of Psychiatry, Vol. 28, No. 6DURATION OF UNTREATED PSYCHOSIS (DUP) AND PRE-MORBID FUNCTIONING, MAY PREDICT CLINICAL PRESENTATION IN FIRST EPISODE OF PSYCHOSIS (FEP): NORTH-EAST INDIAN STUDY26 April 2019 | Journal of Evidence Based Medicine and Healthcare, Vol. 6, No. 17Psychiatry Research, Vol. 272Journal of Clinical Medicine, Vol. 8, No. 5Acta Psychiatrica Scandinavica, Vol. 138, No. 5Early Intervention in Psychiatry, Vol. 12, No. 4Clinical Psychopharmacology and Neuroscience, Vol. 16, No. 2The impact of cognitive reserve in the outcome of first-episode psychoses: 2-year follow-up studyEuropean Neuropsychopharmacology, Vol. 26, No. 10Schizophrenia Research, Vol. 174, No. 1-3International Journal of Molecular Medicine, Vol. 38, No. 1Psychological Medicine, Vol. 45, No. 1The World Journal of Biological Psychiatry, Vol. 16, No. 4International Journal of Molecular Medicine, Vol. 35, No. 1Short-term functional outcome and premorbid adjustment in clinical high-risk patients. Results of the EPOS project15 April 2020 | European Psychiatry, Vol. 29, No. 6Schizophrenia Bulletin, Vol. 40, No. 1Schizophrenia Bulletin, Vol. 40, No. 6Social Psychiatry and Psychiatric Epidemiology, Vol. 48, No. 7Psychiatry Research, Vol. 209, No. 3Premorbid Functioning and Treatment Response in Recent-Onset SchizophreniaJournal of Clinical Psychopharmacology, Vol. 31, No. 1Psychological Medicine, Vol. 40, No. 5CNS Drugs, Vol. 24, No. 1Neurodevelopmental markers in different psychopathological dimensions of first episode psychosis: The ESPIGAS Study16 April 2020 | European Psychiatry, Vol. 23, No. 8Schizophrenia Research, Vol. 100, No. 1-3SchizophreniaBrain Research, Vol. 1156Neuroscience Letters, Vol. 425, No. 1Schizophrenia Research, Vol. 92, No. 1-3Acta Psychiatrica Scandinavica, Vol. 117, No. 2The Relationship of Premorbid Functioning to Illness Course in Schizophrenia and Psychotic Mood Disorders During Two Years Following First HospitalizationJournal of Nervous & Mental Disease, Vol. 194, No. 10British Journal of Psychiatry, Vol. 189, No. 1Association between functioning in adolescence prior to first admission for schizophrenia and affective disorders and patterns of hospitalizations thereafterSchizophrenia Research, Vol. 73, No. 2-3American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 136B, No. 1Schizophrenia Research, Vol. 75, No. 2-3Acta Psychiatrica Scandinavica, Vol. 112, No. 1Journal of Psychiatric Research, Vol. 38, No. 2British Journal of Psychiatry, Vol. 185, No. 2Schizophrenia Research, Vol. 55, No. 3Schizophrenia Research, Vol. 52, No. 1-2Empirical Validation of Primary Negative Symptoms: Independence From Effects of Medication and PsychosisMary E. Kelley, M.S., Daniel P. van Kammen, M.D., Ph.D., and Daniel N. Allen, Ph.D.1 March 1999 | American Journal of Psychiatry, Vol. 156, No. 3Psychiatry Research, Vol. 85, No. 2Six-Month Outcome following a Relapse of Schizophrenia26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 32, No. 6Course of psychopathology, cognition and neurobiological abnormality in schizophrenia: developmental origins and amelioration by antipsychotics?Journal of Psychiatric Research, Vol. 32, No. 3-4Journal of Psychiatric Research, Vol. 32, No. 3-4Psychiatric Clinics of North America, Vol. 21, No. 1Premorbid Social Functioning in Schizophrenia and Bipolar Disorder: Similarities and DifferencesMary Cannon, M.Sc., M.R.C.Psych., Peter Jones, M.Sc., M.R.C.Psych., Catherine Gilvarry, B.A., Larry Rifkin, M.R.C.Psych., Kwame McKenzie, M.R.C.Psych., Alice Foerster, M.R.C.Psych., and Robin M. Murray, D.Sc.15 January 2015 | American Journal of Psychiatry, Vol. 154, No. 11Developmental trajectory and disease progression in schizophrenia: the conundrum, and insights from a 12-year prospective study in the Monaghan 101Schizophrenia Research, Vol. 23, No. 2Correlations of premorbid adjustment in schizophrenia with auditory event-related potential and neuropsychological abnormalities1 April 2006 | American Journal of Psychiatry, Vol. 153, No. 10Clinical characteristics of Kraepelinian schizophrenia: replication and extension of previous findings1 April 2006 | American Journal of Psychiatry, Vol. 153, No. 6Cognitive Neuropsychiatry, Vol. 1, No. 3Biological Psychiatry, Vol. 38, No. 8Schizophrenia Research, Vol. 15, No. 3Psychological Medicine, Vol. 25, No. 4Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 34, No. 10British Journal of Psychiatry, Vol. 165, No. 3Motivation and Emotion, Vol. 17, No. 3 Volume 149Issue 11 November 1992Pages 1543-1548 Metrics PDF download History Published online 1 April 2006 Published in print 1 November 1992
Publication Year: 1992
Publication Date: 1992-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 86
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot