Publication Information

{'id': 'https://openalex.org/W2408198815', 'doi': None, 'title': '[The molecular basis of resistance to anti-influenza drugs].', 'display_name': '[The molecular basis of resistance to anti-influenza drugs].', 'publication_year': 2006, 'publication_date': '2006-10-01', 'ids': {'openalex': 'https://openalex.org/W2408198815', 'mag': '2408198815', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17037359'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17037359', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103167477', 'display_name': 'Shuji Hatakeyama', 'orcid': 'https://orcid.org/0000-0003-2684-1695'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}, {'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shuji Hatakeyama', 'raw_affiliation_strings': ['Department of Infectious Diseases, Graduate School of Medicine, Institute of Medical Science, University of Tokyo.'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Graduate School of Medicine, Institute of Medical Science, University of Tokyo.', 'institution_ids': ['https://openalex.org/I74801974', 'https://openalex.org/I161296585']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076363097', 'display_name': 'Yoshihiro Kawaoka', 'orcid': 'https://orcid.org/0000-0001-5061-8296'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yoshihiro Kawaoka', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.646, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.641224, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 78}, 'biblio': {'volume': '64', 'issue': '10', 'first_page': '1845', 'last_page': '52'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research Studies', 'score': 0.9552, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research Studies', 'score': 0.9552, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rimantadine', 'display_name': 'Rimantadine', 'score': 0.97333133}, {'id': 'https://openalex.org/keywords/amantadine', 'display_name': 'Amantadine', 'score': 0.91115695}, {'id': 'https://openalex.org/keywords/neuraminidase-inhibitor', 'display_name': 'Neuraminidase inhibitor', 'score': 0.6462217}, {'id': 'https://openalex.org/keywords/adamantane', 'display_name': 'Adamantane', 'score': 0.54832345}, {'id': 'https://openalex.org/keywords/transmissibility', 'display_name': 'Transmissibility (structural dynamics)', 'score': 0.43617567}, {'id': 'https://openalex.org/keywords/h5n1-genetic-structure', 'display_name': 'H5N1 genetic structure', 'score': 0.41857088}], 'concepts': [{'id': 'https://openalex.org/C2780391423', 'wikidata': 'https://www.wikidata.org/wiki/Q42171', 'display_name': 'Rimantadine', 'level': 4, 'score': 0.97333133}, {'id': 'https://openalex.org/C2777374534', 'wikidata': 'https://www.wikidata.org/wiki/Q409761', 'display_name': 'Amantadine', 'level': 2, 'score': 0.91115695}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.78248036}, {'id': 'https://openalex.org/C134164806', 'wikidata': 'https://www.wikidata.org/wiki/Q409485', 'display_name': 'Neuraminidase', 'level': 3, 'score': 0.74270445}, {'id': 'https://openalex.org/C2777538117', 'wikidata': 'https://www.wikidata.org/wiki/Q425196', 'display_name': 'Neuraminidase inhibitor', 'level': 5, 'score': 0.6462217}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.5746582}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5670855}, {'id': 'https://openalex.org/C2779556047', 'wikidata': 'https://www.wikidata.org/wiki/Q351461', 'display_name': 'Adamantane', 'level': 2, 'score': 0.54832345}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.5159215}, {'id': 'https://openalex.org/C16683452', 'wikidata': 'https://www.wikidata.org/wiki/Q7834601', 'display_name': 'Transmissibility (structural dynamics)', 'level': 4, 'score': 0.43617567}, {'id': 'https://openalex.org/C2777546802', 'wikidata': 'https://www.wikidata.org/wiki/Q834390', 'display_name': 'Influenza A virus', 'level': 3, 'score': 0.41994715}, {'id': 'https://openalex.org/C82988372', 'wikidata': 'https://www.wikidata.org/wiki/Q5628866', 'display_name': 'H5N1 genetic structure', 'level': 5, 'score': 0.41857088}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.32753956}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24085721}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.17833638}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.17529872}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.14459062}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.12202281}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C45799244', 'wikidata': 'https://www.wikidata.org/wiki/Q109968206', 'display_name': 'Vibration isolation', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C198394728', 'wikidata': 'https://www.wikidata.org/wiki/Q3695508', 'display_name': 'Vibration', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009980', 'descriptor_name': 'Influenza A virus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009981', 'descriptor_name': 'Influenza B virus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000547', 'descriptor_name': 'Amantadine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000547', 'descriptor_name': 'Amantadine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009980', 'descriptor_name': 'Influenza A virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009981', 'descriptor_name': 'Influenza B virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009439', 'descriptor_name': 'Neuraminidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009439', 'descriptor_name': 'Neuraminidase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17037359', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3101405816', 'https://openalex.org/W2948455240', 'https://openalex.org/W2899126788', 'https://openalex.org/W2171852104', 'https://openalex.org/W2130835056', 'https://openalex.org/W2129168218', 'https://openalex.org/W2128284760', 'https://openalex.org/W2127668938', 'https://openalex.org/W2127476782', 'https://openalex.org/W2099728935', 'https://openalex.org/W2078368610', 'https://openalex.org/W2077909990', 'https://openalex.org/W2063704000', 'https://openalex.org/W2032352890', 'https://openalex.org/W2003317860', 'https://openalex.org/W1991335064', 'https://openalex.org/W1981090797', 'https://openalex.org/W1597780184', 'https://openalex.org/W1567222511', 'https://openalex.org/W1537507249'], 'abstract_inverted_index': {'Influenza': [0], 'A': [1], 'viruses': [2, 19, 97, 109], 'resistant': [3, 30, 63], 'to': [4, 31, 43, 64, 71, 81, 119], 'adamantanes(amantadine': [5], 'and': [6, 27, 110], 'rimantadine)': [7], 'have': [8, 20, 39, 68], 'drastically': [9], 'increased': [10], 'in': [11, 98, 107], 'the': [12, 32, 85, 111, 115], 'last': [13], 'few': [14], 'years.': [15], 'Moreover,': [16], 'these': [17, 120], 'adamantane-resistant': [18], 'acquired': [21], 'resistance': [22, 106, 118], 'without': [23], 'compromising': [24], 'viral': [25], 'pathogenicity': [26], 'transmissibility.': [28], 'Viruses': [29], 'other': [33], 'anti-influenza': [34], 'drugs,': [35], 'neuraminidase': [36], '(NA)': [37], 'inhibitors,': [38], 'also': [40], 'been': [41], 'shown': [42], 'emerge': [44], 'at': [45], 'a': [46], 'rate': [47], 'higher': [48], 'than': [49], 'previously': [50], 'thought.': [51], 'In': [52], 'addition,': [53], 'several': [54], 'recent': [55], 'observations': [56], 'suggest': [57], 'that': [58, 74], 'human-to-human': [59], 'transmission': [60], 'of': [61, 87, 94, 114, 117], 'variants': [62, 76], 'NA': [65, 88], 'inhibitors': [66], 'may': [67], 'occurred,': [69], 'contrary': [70], 'earlier': [72], 'predictions': [73], 'such': [75], 'were': [77], 'much': [78], 'less': [79], 'likely': [80], 'be': [82], 'transmitted.': [83], 'Although': [84], 'prevalence': [86], 'inhibitor': [89], 'resistants': [90], 'remains': [91], 'low,': [92], 'surveillance': [93], 'drug-resistant': [95], 'influenza': [96, 108], 'communities': [99], 'is': [100], 'essential.': [101], 'Here,': [102], 'we': [103], 'review': [104], 'antiviral': [105], 'molecular': [112], 'mechanisms': [113], 'acquisition': [116], 'drugs.': [121]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2408198815', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-07T14:59:15.485745', 'created_date': '2016-06-24'}