Publication Information

{'id': 'https://openalex.org/W2404885310', 'doi': None, 'title': 'Screening of DNA topoisomerase inhibitors', 'display_name': 'Screening of DNA topoisomerase inhibitors', 'publication_year': 2004, 'publication_date': '2004-04-01', 'ids': {'openalex': 'https://openalex.org/W2404885310', 'mag': '2404885310', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15114689'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pubmed/15114689', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112642220', 'display_name': 'Toshiwo Andoh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210088637', 'display_name': 'Soka University', 'ror': 'https://ror.org/003qdfg20', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I4210088637']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshiwo Andoh', 'raw_affiliation_strings': ['Department of Bioinformatics, Faculty of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioinformatics, Faculty of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.', 'institution_ids': ['https://openalex.org/I4210088637']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054003917', 'display_name': 'Ken Umemura', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ken Umemura', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005202536', 'display_name': 'Kae Yanase', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kae Yanase', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035038653', 'display_name': 'Noriko Takahashi', 'orcid': 'https://orcid.org/0000-0003-1025-1690'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Noriko Takahashi', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.119, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.333434, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 61, 'max': 68}, 'biblio': {'volume': '31', 'issue': '4', 'first_page': '495', 'last_page': '500'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11175', 'display_name': 'Gyrotron and Vacuum Electronics Research', 'score': 0.975, 'subfield': {'id': 'https://openalex.org/subfields/3107', 'display_name': 'Atomic and Molecular Physics, and Optics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.6401026}, {'id': 'https://openalex.org/keywords/topoisomerase-inhibitor', 'display_name': 'Topoisomerase inhibitor', 'score': 0.47057885}, {'id': 'https://openalex.org/keywords/topotecan', 'display_name': 'Topotecan', 'score': 0.43549964}, {'id': 'https://openalex.org/keywords/anticancer-drug', 'display_name': 'Anticancer drug', 'score': 0.4193405}], 'concepts': [{'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.9064736}, {'id': 'https://openalex.org/C2778119113', 'wikidata': 'https://www.wikidata.org/wiki/Q418817', 'display_name': 'Etoposide', 'level': 3, 'score': 0.83365786}, {'id': 'https://openalex.org/C2780259306', 'wikidata': 'https://www.wikidata.org/wiki/Q412197', 'display_name': 'Irinotecan', 'level': 4, 'score': 0.7738582}, {'id': 'https://openalex.org/C2781303535', 'wikidata': 'https://www.wikidata.org/wiki/Q18936', 'display_name': 'Doxorubicin', 'level': 3, 'score': 0.69217604}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.6401026}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.5197977}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5175911}, {'id': 'https://openalex.org/C2778616834', 'wikidata': 'https://www.wikidata.org/wiki/Q281044', 'display_name': 'Topoisomerase inhibitor', 'level': 4, 'score': 0.47057885}, {'id': 'https://openalex.org/C2781209748', 'wikidata': 'https://www.wikidata.org/wiki/Q419953', 'display_name': 'Topotecan', 'level': 3, 'score': 0.43549964}, {'id': 'https://openalex.org/C3018146709', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Anticancer drug', 'level': 3, 'score': 0.4193405}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41550255}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.39951855}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3899571}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.37497038}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.34070218}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33622062}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.29671595}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.2798398}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20297617}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.1998165}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15119758}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D059003', 'descriptor_name': 'Topoisomerase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026942', 'descriptor_name': 'DNA Topoisomerases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026942', 'descriptor_name': 'DNA Topoisomerases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077146', 'descriptor_name': 'Irinotecan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pubmed/15114689', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15114689', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.81, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W574455832', 'https://openalex.org/W3088400226', 'https://openalex.org/W3021314536', 'https://openalex.org/W2980164919', 'https://openalex.org/W2937890444', 'https://openalex.org/W2932081683', 'https://openalex.org/W2784709079', 'https://openalex.org/W2560110815', 'https://openalex.org/W2507958286', 'https://openalex.org/W2409574046', 'https://openalex.org/W2398614440', 'https://openalex.org/W2383777176', 'https://openalex.org/W2346299219', 'https://openalex.org/W2253758274', 'https://openalex.org/W2090745860', 'https://openalex.org/W2072497885', 'https://openalex.org/W2060199545', 'https://openalex.org/W2059731771', 'https://openalex.org/W2054486764', 'https://openalex.org/W2032535564'], 'abstract_inverted_index': {'It': [0], 'has': [1], 'been': [2], 'established': [3], 'that': [4], 'etoposide': [5], '(ETP),': [6], 'adriamycin': [7], '(doxorubicin:': [8], 'DOX)': [9], 'and': [10, 51, 68, 70, 78], 'irinotecan': [11], '(CPT-11),': [12], 'efficacious': [13], 'antitumor': [14], 'drugs': [15, 40, 62], 'widely': [16], 'used': [17], 'in': [18, 24, 79], 'clinics,': [19], 'target': [20], 'DNA': [21], 'topoisomerases': [22], '(topo)': [23], 'vivo.': [25], 'The': [26], 'present': [27], 'report': [28], 'attempts': [29], 'to': [30], 'explain': [31], 'why': [32], 'topos': [33, 64], 'are': [34, 65, 74], 'the': [35, 42, 49], 'good': [36], 'targets': [37], 'of': [38, 44, 46, 48, 55], 'anticancer': [39, 61], 'from': [41], 'point': [43], 'view': [45], 'enzymology': [47], 'enzymes': [50], 'cell': [52], 'cycle': [53], 'behavior': [54], 'tumor': [56], 'cells.': [57], 'Thus,': [58], 'many': [59], 'candidate': [60], 'targeting': [63], 'being': [66, 75], 'screened,': [67], 'preclinical': [69], 'clinical': [71], 'studies': [72], 'thereof': [73], 'conducted': [76], 'world-wide': [77], 'Japan.': [80]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2404885310', 'counts_by_year': [], 'updated_date': '2024-12-08T12:43:07.264818', 'created_date': '2016-06-24'}