Title: Adapter Molecules in Immune Receptor Signaling
Abstract: Adapter proteins are critical components of the T cell and B cell receptor signaling pathways. Although they do not contain enzymatic properties, adapters enable signal propagation by coordinating the assembly of signaling proteins in the proper spatiotemporal orientation. These complexes are highly dynamic and dependent on multiple protein–protein and protein–lipid interactions. LAT and SLP-76 are two T cell adapter proteins that are required for T cell development and function. Using these two adapters as examples, this article illustrates the critical nature of adapters in immune cell signaling and how the protein domains and motifs present in adapter proteins regulate this process.
Publication Year: 2016
Publication Date: 2016-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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