Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2404279166', 'doi': 'https://doi.org/10.1016/s0022-5347(17)40247-3', 'title': 'In Vivo Antiproliferative Effects of Gamma-Interferon and Tumor Necrosis Factor Alpha in a Rat Renal Cell Carcinoma Model System', 'display_name': 'In Vivo Antiproliferative Effects of Gamma-Interferon and Tumor Necrosis Factor Alpha in a Rat Renal Cell Carcinoma Model System', 'publication_year': 1990, 'publication_date': '1990-06-01', 'ids': {'openalex': 'https://openalex.org/W2404279166', 'doi': 'https://doi.org/10.1016/s0022-5347(17)40247-3', 'mag': '2404279166', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2111411'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(17)40247-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037691698', 'display_name': 'R. Jeroen A. van Moorselaar', 'orcid': 'https://orcid.org/0000-0002-2559-9254'}, 'institutions': [{'id': 'https://openalex.org/I2802500869', 'display_name': 'Biomedical Primate Research Centre', 'ror': 'https://ror.org/02ahxbh87', 'country_code': 'NL', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802500869']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Reindert J.A. Van moorselaar', 'raw_affiliation_strings': ['From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands', 'institution_ids': ['https://openalex.org/I2802500869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029291457', 'display_name': 'Anton J.M.C. Beniers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802500869', 'display_name': 'Biomedical Primate Research Centre', 'ror': 'https://ror.org/02ahxbh87', 'country_code': 'NL', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802500869']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Anton J.M.C. Beniers', 'raw_affiliation_strings': ['From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands', 'institution_ids': ['https://openalex.org/I2802500869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042366567', 'display_name': 'B T Hendriks', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802500869', 'display_name': 'Biomedical Primate Research Centre', 'ror': 'https://ror.org/02ahxbh87', 'country_code': 'NL', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802500869']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ben Th. Hendriks', 'raw_affiliation_strings': ['From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands', 'institution_ids': ['https://openalex.org/I2802500869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038929762', 'display_name': 'P H van der Meide', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802500869', 'display_name': 'Biomedical Primate Research Centre', 'ror': 'https://ror.org/02ahxbh87', 'country_code': 'NL', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802500869']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Peter H. Van Der Meide', 'raw_affiliation_strings': ['From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands', 'institution_ids': ['https://openalex.org/I2802500869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038693465', 'display_name': 'Huub Schellekens', 'orcid': 'https://orcid.org/0000-0002-8503-3965'}, 'institutions': [{'id': 'https://openalex.org/I2802500869', 'display_name': 'Biomedical Primate Research Centre', 'ror': 'https://ror.org/02ahxbh87', 'country_code': 'NL', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802500869']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Huub Schellekens', 'raw_affiliation_strings': ['From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands', 'institution_ids': ['https://openalex.org/I2802500869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024919772', 'display_name': 'F.M.J. Debruyne', 'orcid': 'https://orcid.org/0000-0002-6103-199X'}, 'institutions': [{'id': 'https://openalex.org/I2802500869', 'display_name': 'Biomedical Primate Research Centre', 'ror': 'https://ror.org/02ahxbh87', 'country_code': 'NL', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802500869']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Frans M.J. Debruyne', 'raw_affiliation_strings': ['From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands', 'institution_ids': ['https://openalex.org/I2802500869']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060302039', 'display_name': 'Jack A. Schalken', 'orcid': 'https://orcid.org/0000-0001-8274-7797'}, 'institutions': [{'id': 'https://openalex.org/I2802500869', 'display_name': 'Biomedical Primate Research Centre', 'ror': 'https://ror.org/02ahxbh87', 'country_code': 'NL', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802500869']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jack A. Schalken', 'raw_affiliation_strings': ['From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'From the Dept of Urology, Urologic Research Laboratory, University Hospital Nijmegen, Nijmegen and the Primate Center, TNO, Rijswijk, The Netherlands', 'institution_ids': ['https://openalex.org/I2802500869']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.92, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.593437, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '143', 'issue': '6', 'first_page': '1247', 'last_page': '1251'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11346', 'display_name': 'Role of Mast Cells in Immunoregulation and Disease', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11346', 'display_name': 'Role of Mast Cells in Immunoregulation and Disease', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunobiology of Dendritic Cells', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/antigen-presentation', 'display_name': 'Antigen Presentation', 'score': 0.499371}], 'concepts': [{'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.7116239}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6938262}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.67275465}, {'id': 'https://openalex.org/C2777472916', 'wikidata': 'https://www.wikidata.org/wiki/Q1164529', 'display_name': 'Renal cell carcinoma', 'level': 2, 'score': 0.65853155}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.5381935}, {'id': 'https://openalex.org/C503630168', 'wikidata': 'https://www.wikidata.org/wiki/Q178069', 'display_name': 'Necrosis', 'level': 2, 'score': 0.49768546}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.46802622}, {'id': 'https://openalex.org/C2909179924', 'wikidata': 'https://www.wikidata.org/wiki/Q6046488', 'display_name': 'Alpha interferon', 'level': 3, 'score': 0.42806014}, {'id': 'https://openalex.org/C2780841837', 'wikidata': 'https://www.wikidata.org/wiki/Q24741149', 'display_name': 'Interferon gamma', 'level': 3, 'score': 0.41640285}, {'id': 'https://openalex.org/C2777546739', 'wikidata': 'https://www.wikidata.org/wiki/Q33525', 'display_name': 'Carcinoma', 'level': 2, 'score': 0.41463196}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.35466725}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32115328}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.30079132}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.26727873}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.14989245}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004306', 'descriptor_name': 'Dose-Response Relationship, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011917', 'descriptor_name': 'Rats, Inbred Lew', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(17)40247-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2111411', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.85, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W111083711', 'https://openalex.org/W1488633144', 'https://openalex.org/W1501976972', 'https://openalex.org/W1507995773', 'https://openalex.org/W1513377274', 'https://openalex.org/W1581118634', 'https://openalex.org/W1849550043', 'https://openalex.org/W1984949243', 'https://openalex.org/W1989705551', 'https://openalex.org/W2019223926', 'https://openalex.org/W2021914855', 'https://openalex.org/W2047052568', 'https://openalex.org/W2051828182', 'https://openalex.org/W2083726090', 'https://openalex.org/W2083735475', 'https://openalex.org/W2099060758', 'https://openalex.org/W2102583295', 'https://openalex.org/W2107403843', 'https://openalex.org/W2113497740', 'https://openalex.org/W2115506517', 'https://openalex.org/W2120137683', 'https://openalex.org/W2143826392', 'https://openalex.org/W2149724818', 'https://openalex.org/W2172109321', 'https://openalex.org/W2276982989', 'https://openalex.org/W2419353775', 'https://openalex.org/W2467402094', 'https://openalex.org/W83380745'], 'related_works': ['https://openalex.org/W2804530609', 'https://openalex.org/W2416574063', 'https://openalex.org/W2414858665', 'https://openalex.org/W2412960471', 'https://openalex.org/W2409509982', 'https://openalex.org/W2398766250', 'https://openalex.org/W2333389543', 'https://openalex.org/W2028855342', 'https://openalex.org/W1967482218', 'https://openalex.org/W1041627362'], 'abstract_inverted_index': {'No': [0], 'AccessJournal': [1], 'of': [2, 9, 146, 202, 213, 230, 252, 282, 290, 313, 338, 381, 396, 422, 447], 'Urology1': [3], 'Jun': [4], '1990In': [5], 'Vivo': [6], 'Antiproliferative': [7], 'Effects': [8], 'Gamma-Interferon': [10], 'and': [11, 44, 118, 149, 321, 360, 376, 392, 416, 424, 431, 441, 474], 'Tumor': [12, 189, 384, 388, 442], 'Necrosis': [13, 389, 443], 'Factor': [14, 390, 438, 444], 'Alpha': [15, 391, 445], 'in': [16, 156, 183, 238, 245, 260, 344, 394, 427, 432], 'a': [17, 157, 184, 235, 246, 310], 'Rat': [18, 382], 'Renal': [19, 428], 'Cell': [20, 429], 'Carcinoma': [21], 'Model': [22], 'System': [23], 'Reindert': [24, 48, 478], 'J.A.': [25, 49, 52, 479], 'Van': [26, 36, 50, 53, 85, 89, 370, 480, 505], 'moorselaar,': [27], 'Anton': [28, 61, 487], 'J.M.C.': [29, 62, 64, 488], 'Beniers,': [30], 'Ben': [31, 72, 495], 'Th.': [32, 73, 75, 496], 'Hendriks,': [33], 'Peter': [34, 83, 503], 'H.': [35, 84, 88, 504], 'Der': [37, 86, 90, 371, 506], 'Meide,': [38], 'Huub': [39, 98, 513], 'Schellekens,': [40], 'Frans': [41, 107, 520], 'M.J.': [42, 108, 110, 521], 'Debruyne,': [43], 'Jack': [45, 119, 528], 'A.': [46, 120, 122, 529], 'Schalken': [47, 123, 377, 530], 'moorselaarReindert': [51], 'moorselaar': [54, 481], 'More': [55, 66, 77, 92, 101, 112, 124, 482, 490, 498, 508, 515, 523, 531], 'articles': [56, 67, 78, 93, 102, 113, 125, 483, 491, 499, 509, 516, 524, 532], 'by': [57, 68, 79, 94, 103, 114, 126, 354, 387, 435, 468, 484, 492, 500, 510, 517, 525, 533], 'this': [58, 69, 80, 95, 104, 115, 127, 485, 493, 501, 511, 518, 526, 534], 'author': [59, 70, 81, 96, 105, 116, 128, 486, 494, 502, 512, 519, 527, 535], ',': [60, 71, 82, 97, 106, 117], 'BeniersAnton': [63], 'Beniers': [65, 489], 'HendriksBen': [74], 'Hendriks': [76, 366, 497], 'MeidePeter': [87], 'Meide': [91, 372, 507], 'SchellekensHuub': [99], 'Schellekens': [100, 514], 'DebruyneFrans': [109], 'Debruyne': [111, 374, 522], 'SchalkenJack': [121], 'View': [129], 'All': [130, 537], 'Author': [131], 'Informationhttps://doi.org/10.1016/S0022-5347(17)40247-3AboutPDF': [132], 'ToolsAdd': [133], 'to': [134, 256, 269, 315], 'favoritesDownload': [135], 'CitationsTrack': [136], 'CitationsPermissionsReprints': [137], 'ShareFacebookLinked': [138], 'InTwitterEmail': [139], 'We': [140], 'have': [141, 205], 'investigated': [142], 'the': [143, 169, 197, 203, 227, 231, 239, 253, 272], 'antiproliferative': [144, 209], 'activities': [145], 'recombinant': [147, 150], 'rat-gamma-interferon': [148], 'human': [151], 'tumor': [152, 165, 180, 219, 236, 247, 278, 288, 302, 311, 322, 330], 'necrosis': [153, 190, 323], 'factor': [154, 191, 324], 'alpha': [155, 192], 'rat': [158], 'renal': [159], 'cell': [160], 'carcinoma': [161], 'model': [162], 'system.': [163], 'The': [164, 211, 294, 355, 420, 469], 'was': [166, 193, 275, 307], 'transplanted': [167], 'subcutaneously,': [168], 'drugs': [170, 204, 340], 'were': [171], 'administered': [172], 'peritumorally.': [173], 'Gamma-interferon': [174], 'treatment': [175, 254, 306], 'starting': [176], 'two': [177, 257, 314], 'days': [178], 'after': [179], 'implantation': [181], 'resulted': [182, 259], 'dose-dependent': [185], 'growth': [186, 220, 289, 303], 'inhibiting': [187], 'effect.': [188], 'only': [194], 'effective': [195, 327, 343], 'at': [196, 280, 309, 328], 'highest': [198, 215, 298], 'concentration.': [199], 'Different': [200], 'combinations': [201], 'additive': [206], 'or': [207], 'synergistic': [208], 'effects.': [210], 'combination': [212, 295], 'both': [214, 297], 'doses': [216], 'completely': [217], 'inhibited': [218, 301], 'without': [221], 'any': [222], 'obvious': [223], 'toxic': [224], 'effects': [225], 'on': [226, 277], 'rats.': [228], 'Rechallenge': [229], 'cured': [232], 'rats': [233], 'with': [234, 296, 319], 'piece': [237], 'contralateral': [240], 'flank': [241], 'did': [242], 'not': [243, 286], 'result': [244], 'specific': [248], 'immune': [249], 'response.': [250], 'Shortening': [251], 'period': [255], 'weeks': [258], 'an': [261, 291, 345], 'increased': [262], 'lag-period,': [263], 'but': [264], 'finally': [265], 'all': [266], 'tumors': [267], 'started': [268, 308], 'grow.': [270], 'Furthermore,': [271], 'antitumor': [273], 'effect': [274], 'dependent': [276], 'volume': [279, 312], 'start': [281], 'therapy.': [283], 'Monotherapy': [284], 'could': [285], 'inhibit': [287], 'established': [292], 'tumor.': [293], 'doses,': [299], 'however,': [300], 'even': [304], 'when': [305], 'five': [316], 'cm3.': [317], 'Treatment': [318], 'gamma-interferon': [320], 'is': [325, 341], 'most': [326, 342], 'low': [329], 'burden.': [331], 'These': [332], 'studies': [333], 'suggest': [334], 'that': [335], 'clinical': [336], 'application': [337], 'these': [339], 'adjuvant': [346], 'setting.': [347], '(J.': [348], 'Urol,': [349], '143:1247–1251,': [350], '1990)': [351], '©': [352], '1990': [353, 467], 'American': [356, 470], 'Urological': [357, 471], 'Association': [358, 472], 'Education': [359, 473], 'Research,': [361, 475], 'Inc.FiguresReferencesRelatedDetailsCited': [362], 'ByVan': [363], 'Moorselaar': [364], 'R,': [365, 411], 'B,': [367], 'Borm': [368], 'G,': [369], 'P,': [373], 'F': [375], 'J': [378, 415], '(2018)': [379, 419], 'Inhibition': [380], 'Bladder': [383], '(Rbt323)': [385], 'Growth': [386, 437], 'Interferon-Gamma': [393], 'VivoJournal': [395], 'Urology,': [397, 448], 'VOL.': [398, 449], '148,': [399, 450], 'NO.': [400, 451], '2': [401], 'Part': [402], '1,': [403], '(458-462),': [404], 'Online': [405, 454], 'publication': [406, 455], 'date:': [407, 456], '1-Aug-1992.Koo': [408], 'A,': [409], 'Chiu': [410], 'Soong': [412], 'J,': [413], 'Dekernion': [414], 'Belldegrun': [417], 'A': [418], 'Expression': [421], 'C-Jun': [423], 'Junb': [425], 'mRNA': [426], 'Cancer': [430], 'Vitro': [433], 'Regulation': [434], 'Transforming': [436], 'Beta': [439], '1': [440], '1Journal': [446], '4,': [452], '(1314-1318),': [453], '1-Oct-1992.': [457], 'Volume': [458], '143Issue': [459], '6June': [460], '1990Page:': [461], '1247-1251': [462], 'Advertisement': [463, 538], 'Copyright': [464], '&': [465], 'Permissions©': [466], 'Inc.MetricsAuthor': [476], 'Information': [477], 'Expand': [536], 'PDF': [539], 'DownloadLoading': [540], '...': [541]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2404279166', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-01T05:57:25.875487', 'created_date': '2016-06-24'}