Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2403891676', 'doi': 'https://doi.org/10.1183/13993003.00014-2016', 'title': 'Cessation of long-acting β2-agonist in children with persistent asthma on inhaled corticosteroids', 'display_name': 'Cessation of long-acting β2-agonist in children with persistent asthma on inhaled corticosteroids', 'publication_year': 2016, 'publication_date': '2016-05-26', 'ids': {'openalex': 'https://openalex.org/W2403891676', 'doi': 'https://doi.org/10.1183/13993003.00014-2016', 'mag': '2403891676', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27230440'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1183/13993003.00014-2016', 'pdf_url': 'https://erj.ersjournals.com/content/erj/48/2/558.full.pdf', 'source': {'id': 'https://openalex.org/S4210207896', 'display_name': 'European Respiratory Journal', 'issn_l': '0903-1936', 'issn': ['0903-1936', '1399-3003'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317833', 'host_organization_name': 'European Respiratory Society', 'host_organization_lineage': ['https://openalex.org/P4310317833'], 'host_organization_lineage_names': ['European Respiratory Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://erj.ersjournals.com/content/erj/48/2/558.full.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5065533338', 'display_name': 'Francine M Ducharme', 'orcid': 'https://orcid.org/0000-0001-5096-0614'}, 'institutions': [{'id': 'https://openalex.org/I70931966', 'display_name': 'Université de Montréal', 'ror': 'https://ror.org/0161xgx34', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I70931966']}, {'id': 'https://openalex.org/I2802351361', 'display_name': 'Centre Hospitalier Universitaire Sainte-Justine', 'ror': 'https://ror.org/01gv74p78', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802351361']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Francine M. Ducharme', 'raw_affiliation_strings': ['Clinical Research and Knowledge Translation Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, QC, Canada', 'Dept of Pediatrics, University of Montreal, Montreal, QC, Canada', 'Dept of Social and Preventive Medicine, University of Montreal, Montreal, QC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Dept of Pediatrics, University of Montreal, Montreal, QC, Canada', 'institution_ids': ['https://openalex.org/I70931966']}, {'raw_affiliation_string': 'Dept of Social and Preventive Medicine, University of Montreal, Montreal, QC, Canada', 'institution_ids': ['https://openalex.org/I70931966']}, {'raw_affiliation_string': 'Clinical Research and Knowledge Translation Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, QC, Canada', 'institution_ids': ['https://openalex.org/I2802351361']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089465611', 'display_name': 'Roxanne Gagnon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802351361', 'display_name': 'Centre Hospitalier Universitaire Sainte-Justine', 'ror': 'https://ror.org/01gv74p78', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802351361']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Roxanne Gagnon', 'raw_affiliation_strings': ['Clinical Research and Knowledge Translation Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, QC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Clinical Research and Knowledge Translation Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, QC, Canada', 'institution_ids': ['https://openalex.org/I2802351361']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013132588', 'display_name': 'Brigitte Bénard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802351361', 'display_name': 'Centre Hospitalier Universitaire Sainte-Justine', 'ror': 'https://ror.org/01gv74p78', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802351361']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Brigitte Bénard', 'raw_affiliation_strings': ['Clinical Research and Knowledge Translation Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, QC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Clinical Research and Knowledge Translation Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, QC, Canada', 'institution_ids': ['https://openalex.org/I2802351361']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057563092', 'display_name': 'Sze Man Tse', 'orcid': 'https://orcid.org/0000-0002-0295-0064'}, 'institutions': [{'id': 'https://openalex.org/I2802351361', 'display_name': 'Centre Hospitalier Universitaire Sainte-Justine', 'ror': 'https://ror.org/01gv74p78', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802351361']}, {'id': 'https://openalex.org/I70931966', 'display_name': 'Université de Montréal', 'ror': 'https://ror.org/0161xgx34', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I70931966']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sze Man Tse', 'raw_affiliation_strings': ['Clinical Research and Knowledge Translation Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, QC, Canada', 'Dept of Pediatrics, University of Montreal, Montreal, QC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Clinical Research and Knowledge Translation Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, QC, Canada', 'institution_ids': ['https://openalex.org/I2802351361']}, {'raw_affiliation_string': 'Dept of Pediatrics, University of Montreal, Montreal, QC, Canada', 'institution_ids': ['https://openalex.org/I70931966']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040596908', 'display_name': 'Robert Thivierge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70931966', 'display_name': 'Université de Montréal', 'ror': 'https://ror.org/0161xgx34', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I70931966']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Robert Thivierge', 'raw_affiliation_strings': ['Dept of Pediatrics, University of Montreal, Montreal, QC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Dept of Pediatrics, University of Montreal, Montreal, QC, Canada', 'institution_ids': ['https://openalex.org/I70931966']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.578816, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 80}, 'biblio': {'volume': '48', 'issue': '2', 'first_page': '558', 'last_page': '560'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11651', 'display_name': 'Pulmonary Drug Delivery Techniques', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12418', 'display_name': 'Diagnosis and Management of Chronic Cough', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/asthma', 'display_name': 'Asthma', 'score': 0.516756}, {'id': 'https://openalex.org/keywords/b2-receptor', 'display_name': 'B2 receptor', 'score': 0.4667611}, {'id': 'https://openalex.org/keywords/salmeterol', 'display_name': 'Salmeterol', 'score': 0.42660478}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8834324}, {'id': 'https://openalex.org/C2991922776', 'wikidata': 'https://www.wikidata.org/wiki/Q210420', 'display_name': 'Inhaled corticosteroids', 'level': 3, 'score': 0.795271}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.785594}, {'id': 'https://openalex.org/C2776804153', 'wikidata': 'https://www.wikidata.org/wiki/Q210420', 'display_name': 'Corticosteroid', 'level': 2, 'score': 0.5416546}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.53747624}, {'id': 'https://openalex.org/C3018890749', 'wikidata': 'https://www.wikidata.org/wiki/Q204711', 'display_name': 'Food and drug administration', 'level': 2, 'score': 0.527171}, {'id': 'https://openalex.org/C3017940444', 'wikidata': 'https://www.wikidata.org/wiki/Q287961', 'display_name': 'B2 receptor', 'level': 4, 'score': 0.4667611}, {'id': 'https://openalex.org/C2776719499', 'wikidata': 'https://www.wikidata.org/wiki/Q424333', 'display_name': 'Salmeterol', 'level': 3, 'score': 0.42660478}, {'id': 'https://openalex.org/C187212893', 'wikidata': 'https://www.wikidata.org/wiki/Q123028', 'display_name': 'Pediatrics', 'level': 1, 'score': 0.41932282}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.3578274}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.34033638}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24392444}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.12878582}, {'id': 'https://openalex.org/C2779591629', 'wikidata': 'https://www.wikidata.org/wiki/Q24745328', 'display_name': 'Bradykinin', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000305', 'descriptor_name': 'Adrenal Cortex Hormones', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000318', 'descriptor_name': 'Adrenergic beta-Agonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018927', 'descriptor_name': 'Anti-Asthmatic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D028761', 'descriptor_name': 'Withholding Treatment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000280', 'descriptor_name': 'Administration, Inhalation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000305', 'descriptor_name': 'Adrenal Cortex Hormones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000318', 'descriptor_name': 'Adrenergic beta-Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018927', 'descriptor_name': 'Anti-Asthmatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007223', 'descriptor_name': 'Infant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1183/13993003.00014-2016', 'pdf_url': 'https://erj.ersjournals.com/content/erj/48/2/558.full.pdf', 'source': {'id': 'https://openalex.org/S4210207896', 'display_name': 'European Respiratory Journal', 'issn_l': '0903-1936', 'issn': ['0903-1936', '1399-3003'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317833', 'host_organization_name': 'European Respiratory Society', 'host_organization_lineage': ['https://openalex.org/P4310317833'], 'host_organization_lineage_names': ['European Respiratory Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27230440', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1183/13993003.00014-2016', 'pdf_url': 'https://erj.ersjournals.com/content/erj/48/2/558.full.pdf', 'source': {'id': 'https://openalex.org/S4210207896', 'display_name': 'European Respiratory Journal', 'issn_l': '0903-1936', 'issn': ['0903-1936', '1399-3003'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317833', 'host_organization_name': 'European Respiratory Society', 'host_organization_lineage': ['https://openalex.org/P4310317833'], 'host_organization_lineage_names': ['European Respiratory Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.61, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320307776', 'funder_display_name': 'Merck', 'award_id': 'Merck Investigator Studies Program 50925'}], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1645202110', 'https://openalex.org/W1897527580', 'https://openalex.org/W1983694202', 'https://openalex.org/W1988431729', 'https://openalex.org/W2016715361', 'https://openalex.org/W2056770521', 'https://openalex.org/W2069105771', 'https://openalex.org/W2091144167', 'https://openalex.org/W2146960414', 'https://openalex.org/W2153149205', 'https://openalex.org/W2158067376', 'https://openalex.org/W2170364105', 'https://openalex.org/W2170374219', 'https://openalex.org/W2288873333', 'https://openalex.org/W2910567650', 'https://openalex.org/W387031605', 'https://openalex.org/W4239915351'], 'related_works': ['https://openalex.org/W4241532160', 'https://openalex.org/W4239336517', 'https://openalex.org/W2350763737', 'https://openalex.org/W2312282834', 'https://openalex.org/W2162450621', 'https://openalex.org/W2117287154', 'https://openalex.org/W2090592797', 'https://openalex.org/W2025221899', 'https://openalex.org/W1997523076', 'https://openalex.org/W126673384'], 'abstract_inverted_index': {'International': [0], 'guidelines': [1], 'recommend': [2], 'adding': [3], 'long-acting': [4, 123], 'β2-agonists': [5, 124], '(LABA)': [6], 'to': [7, 36, 47, 88, 99, 125, 133], 'inhaled': [8, 126], 'corticosteroids': [9, 76], '(ICS)': [10], 'as': [11], 'a': [12, 68], 'step': [13], '3': [14], 'or': [15, 24], '4': [16], 'strategy': [17], 'in': [18, 20, 30, 43, 60, 150, 168], 'children': [19, 44, 117, 166], 'whom': [21], 'ICS,': [22], 'with': [23, 56, 63], 'without': [25], 'adjunct': [26], 'therapy,': [27], 'is': [28, 106], 'ineffective': [29], 'adequately': [31], 'controlling': [32], 'asthma': [33, 109], '[1–4].': [34], 'Contrary': [35], 'adults,': [37], 'the': [38, 93, 151, 162, 165], 'beneficial': [39], 'effects': [40], 'of': [41, 137, 164], 'ICS/LABA': [42], 'are': [45, 131], 'limited': [46], 'improving': [48], 'lung': [49], 'function': [50], 'and': [51, 85, 96, 141, 160], 'short-acting': [52], 'β2-agonist': [53], 'use': [54], '(SABA),': [55], 'no': [57], 'significant': [58], 'reduction': [59], 'symptoms': [61], 'compared': [62], 'ICS': [64], 'alone': [65], '[5];': [66], 'moreover,': [67], 'nonsignificant': [69], 'trend': [70], 'towards': [71], 'more': [72], 'exacerbations': [73], 'requiring': [74], 'oral': [75], 'and/or': [77], 'hospital': [78], 'admissions': [79], 'raised': [80], 'concerns': [81], '[5].': [82], 'Asthma-related': [83], 'intubations': [84], 'deaths': [86], 'linked': [87], 'LABA': [89, 105], '[6]': [90], 'have': [91], 'led': [92], 'US': [94], 'Food': [95], 'Drug': [97], 'Administration': [98], 'issue': [100], 'label': [101], 'changes': [102], 'recommending': [103], 'that': [104], 'discontinued': [107], 'once': [108], 'control': [110], 'has': [111], 'been': [112], 'achieved': [113], '[7].': [114], 'Most': [115], 'asthmatic': [116], 'can': [118], 'be': [119], 'successfully': [120], 'weaned': [121], 'off': [122], 'corticosteroid': [127], 'monotherapy': [128], '<http://ow.ly/10oTtI>': [129], 'We': [130], 'indebted': [132], 'Pierre': [134], 'Gaudreault': [135], '(University': [136], 'Montreal,': [138, 139, 146], 'Canada)': [140, 147], 'Caroline': [142], 'Chartrand': [143], '(CHU': [144], 'Sainte-Justine,': [145], 'who': [148], 'assisted': [149], 'diligent': [152], 'data': [153], 'collection': [154], 'during': [155], 'their': [156], "patients'": [157], 'medical': [158], 'visits': [159], 'thank': [161], 'parents': [163], 'enrolled': [167], 'this': [169], 'study.': [170]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2403891676', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-10T20:48:42.480266', 'created_date': '2016-06-24'}