A comparative study of the regulation of Ca2+ of the activities of the 2-oxoglutarate dehydrogenase complex and NAD+-isocitrate dehydrogenase from a variety of sources

Name: Work Video:
Duration: 3 min 30 s
J G McCormack; R M Denton
{'id': 'https://openalex.org/W2400196432', 'doi': 'https://doi.org/10.1042/bj1960619', 'title': 'A comparative study of the regulation of Ca2+ of the activities of the 2-oxoglutarate dehydrogenase complex and NAD+-isocitrate dehydrogenase from a variety of sources', 'display_name': 'A comparative study of the regulation of Ca2+ of the activities of the 2-oxoglutarate dehydrogenase complex and NAD+-isocitrate dehydrogenase from a variety of sources', 'publication_year': 1981, 'publication_date': '1981-05-15', 'ids': {'openalex': 'https://openalex.org/W2400196432', 'doi': 'https://doi.org/10.1042/bj1960619', 'mag': '2400196432', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7032511', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1163036'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj1960619', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210234214', 'display_name': 'Biochemical Journal', 'issn_l': '0306-3283', 'issn': ['0306-3283'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1163036?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111717423', 'display_name': 'J G McCormack', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J G McCormack', 'raw_affiliation_strings': ['Department ofBiochemistry, University ofBristol Medical School, University Walk, Bristol BS8 I TD, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Department ofBiochemistry, University ofBristol Medical School, University Walk, Bristol BS8 I TD, U.K.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110289733', 'display_name': 'R M Denton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'R M Denton', 'raw_affiliation_strings': ['Department ofBiochemistry, University ofBristol Medical School, University Walk, Bristol BS8 I TD, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Department ofBiochemistry, University ofBristol Medical School, University Walk, Bristol BS8 I TD, U.K.', 'institution_ids': ['https://openalex.org/I36234482']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.906, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 91, 'citation_normalized_percentile': {'value': 0.956997, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '196', 'issue': '2', 'first_page': '619', 'last_page': '624'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/isocitrate-dehydrogenase', 'display_name': 'Isocitrate dehydrogenase', 'score': 0.8810057}, {'id': 'https://openalex.org/keywords/oxoglutarate-dehydrogenase-complex', 'display_name': 'Oxoglutarate dehydrogenase complex', 'score': 0.77268296}], 'concepts': [{'id': 'https://openalex.org/C2777150147', 'wikidata': 'https://www.wikidata.org/wiki/Q261968', 'display_name': 'Isocitrate dehydrogenase', 'level': 3, 'score': 0.8810057}, {'id': 'https://openalex.org/C126093377', 'wikidata': 'https://www.wikidata.org/wiki/Q309518', 'display_name': 'Oxoglutarate dehydrogenase complex', 'level': 5, 'score': 0.77268296}, {'id': 'https://openalex.org/C2776317432', 'wikidata': 'https://www.wikidata.org/wiki/Q412547', 'display_name': 'Dehydrogenase', 'level': 3, 'score': 0.73200816}, {'id': 'https://openalex.org/C75520062', 'wikidata': 'https://www.wikidata.org/wiki/Q15321392', 'display_name': 'NAD+ kinase', 'level': 3, 'score': 0.68957436}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.6536293}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6203903}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51874095}, {'id': 'https://openalex.org/C151325109', 'wikidata': 'https://www.wikidata.org/wiki/Q22327132', 'display_name': 'Branched-chain alpha-keto acid dehydrogenase complex', 'level': 4, 'score': 0.48469284}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.454645}, {'id': 'https://openalex.org/C127848430', 'wikidata': 'https://www.wikidata.org/wiki/Q18027543', 'display_name': 'IDH1', 'level': 4, 'score': 0.41541547}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.04870525}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007521', 'descriptor_name': 'Isocitrate Dehydrogenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007655', 'descriptor_name': 'Ketoglutarate Dehydrogenase Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007658', 'descriptor_name': 'Ketone Oxidoreductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000227', 'descriptor_name': 'Adenine Nucleotides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000227', 'descriptor_name': 'Adenine Nucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007521', 'descriptor_name': 'Isocitrate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007655', 'descriptor_name': 'Ketoglutarate Dehydrogenase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007658', 'descriptor_name': 'Ketone Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008929', 'descriptor_name': 'Mitochondria, Heart', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008929', 'descriptor_name': 'Mitochondria, Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008931', 'descriptor_name': 'Mitochondria, Muscle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008931', 'descriptor_name': 'Mitochondria, Muscle', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009243', 'descriptor_name': 'NAD', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009243', 'descriptor_name': 'NAD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010944', 'descriptor_name': 'Plants', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010944', 'descriptor_name': 'Plants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj1960619', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210234214', 'display_name': 'Biochemical Journal', 'issn_l': '0306-3283', 'issn': ['0306-3283'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1163036', 'pdf_url': 'https://europepmc.org/articles/pmc1163036?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1163036', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7032511', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1163036', 'pdf_url': 'https://europepmc.org/articles/pmc1163036?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life below water', 'id': 'https://metadata.un.org/sdg/14', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W130501137', 'https://openalex.org/W1541372733', 'https://openalex.org/W1580746914', 'https://openalex.org/W1644371783', 'https://openalex.org/W1756031092', 'https://openalex.org/W181688216', 'https://openalex.org/W183190858', 'https://openalex.org/W1977585447', 'https://openalex.org/W2002357266', 'https://openalex.org/W2006598272', 'https://openalex.org/W2008543065', 'https://openalex.org/W2033810389', 'https://openalex.org/W2052746542', 'https://openalex.org/W2053382765', 'https://openalex.org/W2054904385', 'https://openalex.org/W2066011971', 'https://openalex.org/W2094821743', 'https://openalex.org/W2199195742', 'https://openalex.org/W2203986272', 'https://openalex.org/W2227451280', 'https://openalex.org/W2346633182', 'https://openalex.org/W2407836082', 'https://openalex.org/W281530171', 'https://openalex.org/W4211235138', 'https://openalex.org/W4247520258'], 'related_works': ['https://openalex.org/W4317563966', 'https://openalex.org/W2417291538', 'https://openalex.org/W2353247773', 'https://openalex.org/W2261313271', 'https://openalex.org/W2146742335', 'https://openalex.org/W1986256138', 'https://openalex.org/W1968582366', 'https://openalex.org/W1834004242', 'https://openalex.org/W1557898514', 'https://openalex.org/W1533982537'], 'abstract_inverted_index': {'Ca2+': [0, 41], 'was': [1, 108], 'shown': [2], 'to': [3, 93, 111], 'activate': [4], 'oxoglutarate': [5, 84], 'dehydrogenase': [6, 9], 'and': [7, 12, 58, 91], 'NAD+-isocitrate': [8], 'from': [10, 51, 66, 104], 'heart': [11], 'other': [13, 52], 'rat': [14], 'tissues': [15], 'by': [16, 88, 113], 'markedly': [17], 'decreasing': [18], 'the': [19, 23, 45, 64, 79, 83, 102], 'Km': [20, 80], 'values': [21, 81], 'of': [22, 40, 82], 'enzymes': [24, 50, 65], 'for': [25, 101], 'their': [26], 'respective': [27], 'substrates': [28], '[see': [29], 'Denton': [30], '&amp;': [31], 'McCormack': [32], '(1980)': [33], 'FEBS': [34], 'Lett.': [35], '119,': [36], '1-8].': [37], 'Similar': [38], 'effects': [39], 'were': [42, 86], 'observed': [43], 'in': [44, 97], 'present': [46], 'study': [47], 'with': [48, 63], 'both': [49], 'vertebrate': [53], 'sources': [54], '(pigeon,': [55], 'trout,': [56], 'frog': [57], 'human': [59], 'heart),': [60], 'but': [61], 'not': [62, 109], 'blowfly': [67], 'or': [68, 72, 74], 'locust': [69], 'flight': [70], 'muscle,': [71], 'potato': [73], 'Escherichia': [75], 'coli.': [76], 'In': [77], 'contrast,': [78], 'dehydrogenases': [85], 'affected': [87], 'ADP,': [89], 'ATP': [90], 'H+': [92], 'a': [94], 'similar': [95], 'extent': [96], 'every': [98], 'case,': [99], 'except': [100], 'enzyme': [103], 'E.': [105], 'coli,': [106], 'which': [107], 'sensitive': [110], 'regulation': [112], 'these': [114], 'agents.': [115]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2400196432', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-15T18:44:39.680394', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
