Title: S-adenosyl-L-methionine analogues to enhance the production of actinorhodin
Abstract: It is known that overexpression of S-adenosyl-L-methionine (SAM) synthetase or exogenous addition of SAM enhances the production of actinorhodin, one of pigmented antibiotics found from Streptomyces coelicolor. In order to discover a novel compound as a signal molecule to produce actinorhodin instead of SAM, several compounds were synthesized based on the relationships between structures of the SAM analogues and their actinorhodin productivities. Of these, a few compounds showed better productivities of actinorhodin than SAM.
Publication Year: 2006
Publication Date: 2006-07-01
Language: en
Type: article
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Cited By Count: 2
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