Title: A macrophage immunosuppression induced by Leishmania major in BALB/c mice.
Abstract: The purpose of the present study is to investigate the status of the reticuloendothelial system (RES) phagocytic function in relation to Leishmania major infection in highly susceptible BALB/c mice. The RES phagocytosis was monitored by: intravascular clearance of carbon colloid; tissue distribution 99mTechnetium labelled sulphur colloid in RES organs; and serum lysozyme enzyme level. The kinetics of RES phagocytosis during L. major infection was also studied at 0, 3, 5, 7 and 8 weeks post-infection. The results revealed that L. major parasite significantly (p less than 0.001) inhibited macrophage phagocytic function. The maximum phagocyte depression was noticed at 7 weeks following infection. The macrophage phagocytic suppression was also associated with a reduction in liver and spleen uptake of 99mTc and decrease in serum lysozyme level.
Publication Year: 1987
Publication Date: 1987-06-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 6
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