Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2399700455', 'doi': 'https://doi.org/10.1038/srep13928', 'title': 'Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling', 'display_name': 'Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling', 'publication_year': 2015, 'publication_date': '2015-09-10', 'ids': {'openalex': 'https://openalex.org/W2399700455', 'doi': 'https://doi.org/10.1038/srep13928', 'mag': '2399700455', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26355076', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4564764'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep13928', 'pdf_url': 'https://www.nature.com/articles/srep13928.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/srep13928.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103354062', 'display_name': 'Kenji Otsuka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I60134161', 'display_name': 'Nagoya University', 'ror': 'https://ror.org/04chrp450', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I60134161']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Otsuka', 'raw_affiliation_strings': ['Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I60134161']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079197186', 'display_name': 'Mikako Ito', 'orcid': 'https://orcid.org/0000-0002-1351-7602'}, 'institutions': [{'id': 'https://openalex.org/I60134161', 'display_name': 'Nagoya University', 'ror': 'https://ror.org/04chrp450', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I60134161']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mikako Ito', 'raw_affiliation_strings': ['Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I60134161']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022478677', 'display_name': 'Bisei Ohkawara', 'orcid': 'https://orcid.org/0000-0002-1987-458X'}, 'institutions': [{'id': 'https://openalex.org/I60134161', 'display_name': 'Nagoya University', 'ror': 'https://ror.org/04chrp450', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I60134161']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Bisei Ohkawara', 'raw_affiliation_strings': ['Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I60134161']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038516654', 'display_name': 'Akio Masuda', 'orcid': 'https://orcid.org/0000-0002-6437-2853'}, 'institutions': [{'id': 'https://openalex.org/I60134161', 'display_name': 'Nagoya University', 'ror': 'https://ror.org/04chrp450', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I60134161']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akio Masuda', 'raw_affiliation_strings': ['Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I60134161']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102780462', 'display_name': 'Yu Kawakami', 'orcid': 'https://orcid.org/0009-0009-8592-2912'}, 'institutions': [{'id': 'https://openalex.org/I60134161', 'display_name': 'Nagoya University', 'ror': 'https://ror.org/04chrp450', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I60134161']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yu Kawakami', 'raw_affiliation_strings': ['Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I60134161']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084367056', 'display_name': 'K Sahashi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16528096', 'display_name': 'Aichi Medical University', 'ror': 'https://ror.org/02h6cs343', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I16528096']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ko Sahashi', 'raw_affiliation_strings': ['Department of Neurology, Aichi Medical University, Aichi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Aichi Medical University, Aichi, Japan', 'institution_ids': ['https://openalex.org/I16528096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016446325', 'display_name': 'Hiroshi Nishida', 'orcid': 'https://orcid.org/0000-0001-8833-1901'}, 'institutions': [{'id': 'https://openalex.org/I4210134253', 'display_name': 'Gifu Prefectural General Medical Center', 'ror': 'https://ror.org/03c266r37', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134253']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Nishida', 'raw_affiliation_strings': ['Department of Neurology, Gifu Prefectural General Medical Center, Gifu, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Gifu Prefectural General Medical Center, Gifu, Japan', 'institution_ids': ['https://openalex.org/I4210134253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033654754', 'display_name': 'Naoki Mabuchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114349', 'display_name': 'Okazaki City Hospital', 'ror': 'https://ror.org/01z9vrt66', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210114349']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naoki Mabuchi', 'raw_affiliation_strings': ['Department of Neurology, Okazaki City Hospital, Okazaki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Okazaki City Hospital, Okazaki, Japan', 'institution_ids': ['https://openalex.org/I4210114349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001612263', 'display_name': 'Akemi Takano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210123267', 'display_name': 'Meitetsu Hospital', 'ror': 'https://ror.org/021bj7008', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123267']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akemi Takano', 'raw_affiliation_strings': ['Department of Neurology, Meitetsu Hospital, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Meitetsu Hospital, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I4210123267']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101535860', 'display_name': 'Andrew G. Engel', 'orcid': 'https://orcid.org/0000-0001-8029-5010'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew G. Engel', 'raw_affiliation_strings': ['Department of Neurology, Mayo Clinic, Rochester, Minnesota'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Mayo Clinic, Rochester, Minnesota', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017751776', 'display_name': 'Kinji Ohno', 'orcid': 'https://orcid.org/0000-0002-1529-2750'}, 'institutions': [{'id': 'https://openalex.org/I60134161', 'display_name': 'Nagoya University', 'ror': 'https://ror.org/04chrp450', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I60134161']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kinji Ohno', 'raw_affiliation_strings': ['Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I60134161']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 6.155, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '5', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11271', 'display_name': 'Myasthenia Gravis and Thymic Tumors Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11271', 'display_name': 'Myasthenia Gravis and Thymic Tumors Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11735', 'display_name': 'Guillain-Barré Syndrome and Related Neuropathies', 'score': 0.9762, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/agrin', 'display_name': 'Agrin', 'score': 0.9754851}, {'id': 'https://openalex.org/keywords/musk-antibodies', 'display_name': 'MuSK Antibodies', 'score': 0.573904}], 'concepts': [{'id': 'https://openalex.org/C2779024559', 'wikidata': 'https://www.wikidata.org/wiki/Q4694120', 'display_name': 'Agrin', 'level': 4, 'score': 0.9754851}, {'id': 'https://openalex.org/C80161118', 'wikidata': 'https://www.wikidata.org/wiki/Q408520', 'display_name': 'Acetylcholine receptor', 'level': 3, 'score': 0.77384084}, {'id': 'https://openalex.org/C2778816929', 'wikidata': 'https://www.wikidata.org/wiki/Q22676679', 'display_name': 'Acetylcholinesterase', 'level': 3, 'score': 0.6445636}, {'id': 'https://openalex.org/C2777240379', 'wikidata': 'https://www.wikidata.org/wiki/Q776995', 'display_name': 'Neuromuscular junction', 'level': 2, 'score': 0.55206525}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42633188}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4251938}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.41546106}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41154316}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34910464}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3294164}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.22686741}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.13554084}], 'mesh': [{'descriptor_ui': 'D000110', 'descriptor_name': 'Acetylcholinesterase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018171', 'descriptor_name': 'Agrin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001323', 'descriptor_name': 'Autoantibodies', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D026502', 'descriptor_name': 'LDL-Receptor Related Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000110', 'descriptor_name': 'Acetylcholinesterase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000110', 'descriptor_name': 'Acetylcholinesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018171', 'descriptor_name': 'Agrin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001323', 'descriptor_name': 'Autoantibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001323', 'descriptor_name': 'Autoantibodies', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000939', 'descriptor_name': 'Epitopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000939', 'descriptor_name': 'Epitopes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007116', 'descriptor_name': 'Immunization, Passive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026502', 'descriptor_name': 'LDL-Receptor Related Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054730', 'descriptor_name': 'Protein Interaction Domains and Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep13928', 'pdf_url': 'https://www.nature.com/articles/srep13928.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564764', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26355076', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep13928', 'pdf_url': 'https://www.nature.com/articles/srep13928.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.4, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1491950503', 'https://openalex.org/W1503767635', 'https://openalex.org/W1540450162', 'https://openalex.org/W1567347505', 'https://openalex.org/W1568142966', 'https://openalex.org/W1904864670', 'https://openalex.org/W1977090363', 'https://openalex.org/W1977655066', 'https://openalex.org/W1980294445', 'https://openalex.org/W1982623873', 'https://openalex.org/W1984522719', 'https://openalex.org/W1987686381', 'https://openalex.org/W1988570220', 'https://openalex.org/W1990217869', 'https://openalex.org/W1990799654', 'https://openalex.org/W1991623532', 'https://openalex.org/W1995350077', 'https://openalex.org/W1999553070', 'https://openalex.org/W1999944953', 'https://openalex.org/W2005651997', 'https://openalex.org/W2013292781', 'https://openalex.org/W2017784963', 'https://openalex.org/W2025101651', 'https://openalex.org/W2028595146', 'https://openalex.org/W2032465593', 'https://openalex.org/W2032649512', 'https://openalex.org/W2034787916', 'https://openalex.org/W2037931223', 'https://openalex.org/W2038591428', 'https://openalex.org/W2042235212', 'https://openalex.org/W2043698418', 'https://openalex.org/W2044486145', 'https://openalex.org/W2047982560', 'https://openalex.org/W2048457764', 'https://openalex.org/W2053258541', 'https://openalex.org/W2055858894', 'https://openalex.org/W2057313033', 'https://openalex.org/W2058403475', 'https://openalex.org/W2064618072', 'https://openalex.org/W2070470572', 'https://openalex.org/W2076840880', 'https://openalex.org/W2078734091', 'https://openalex.org/W2092431710', 'https://openalex.org/W2107024251', 'https://openalex.org/W2114201015', 'https://openalex.org/W2114428731', 'https://openalex.org/W2115203226', 'https://openalex.org/W2118177888', 'https://openalex.org/W2119039961', 'https://openalex.org/W2122312456', 'https://openalex.org/W2124445030', 'https://openalex.org/W2144090483', 'https://openalex.org/W2150947283', 'https://openalex.org/W2155578438', 'https://openalex.org/W2155823199', 'https://openalex.org/W2156555464', 'https://openalex.org/W2162856159', 'https://openalex.org/W2164681071', 'https://openalex.org/W2170822425', 'https://openalex.org/W2171563433'], 'related_works': ['https://openalex.org/W573671015', 'https://openalex.org/W2137255104', 'https://openalex.org/W2120814314', 'https://openalex.org/W2082782477', 'https://openalex.org/W2061672899', 'https://openalex.org/W1992710299', 'https://openalex.org/W1990103645', 'https://openalex.org/W1968278323', 'https://openalex.org/W1963748908', 'https://openalex.org/W1168805970'], 'abstract_inverted_index': {'MuSK': [0, 13, 31, 57, 77, 132], 'antibody-positive': [1], 'myasthenia': [2], 'gravis': [3], '(MuSK-MG)': [4], 'accounts': [5], 'for': [6, 18], '5': [7], 'to': [8, 40, 56, 76, 104, 162, 189], '15%': [9], 'of': [10, 27, 54, 72, 74, 80, 98, 102, 113, 123, 144, 168], 'autoimmune': [11], 'MG.': [12], 'and': [14, 58, 78, 137, 142, 158, 165, 177], 'LRP4': [15, 157], 'are': [16], 'coreceptors': [17], 'agrin': [19], 'in': [20, 64, 95, 125], 'the': [21, 34, 41, 69, 96, 117, 131, 135, 154, 163, 171], 'signaling': [22, 188], 'pathway': [23], 'that': [24, 48, 90, 111, 184], 'causes': [25], 'clustering': [26, 122], 'acetylcholine': [28], 'receptor': [29], '(AChR).': [30], 'also': [32, 160], 'anchors': [33], 'acetylcholinesterase': [35], '(AChE)/collagen': [36], 'Q': [37], '(ColQ)': [38], 'complex': [39, 173], 'synaptic': [42], 'basal': [43], 'lamina.': [44], 'We': [45, 66], 'previously': [46], 'reported': [47], 'anti-MuSK': [49], 'antibodies': [50, 133], '(MuSK-IgG)': [51], 'block': [52, 79], 'binding': [53, 73, 82], 'ColQ': [55, 75, 114, 159], 'cause': [59], 'partial': [60], 'endplate': [61], 'AChE': [62], 'deficiency': [63], 'mice.': [65], 'here': [67], 'analyzed': [68], 'physiological': [70], 'significance': [71], 'this': [81], 'by': [83], 'MuSK-IgG.': [84], 'In': [85, 127, 146], 'vitro': [86], 'plate-binding': [87], 'assay': [88], 'showed': [89, 183], 'MuSK-IgG': [91, 103, 185], 'blocked': [92, 174], 'MuSK-LRP4': [93, 175], 'interaction': [94, 176], 'presence': [97], 'agrin.': [99], 'Passive': [100], 'transfer': [101], 'Colq-knockout': [105], 'mice': [106], 'attenuated': [107], 'AChR': [108, 124], 'clustering,': [109], 'indicating': [110], 'lack': [112], 'is': [115], 'not': [116], 'key': [118], 'event': [119], 'causing': [120], 'defective': [121], 'MuSK-MG.': [126], 'three': [128], 'MuSK-MG': [129, 149], 'patients,': [130, 150], 'recognized': [134, 152], 'first': [136], 'fourth': [138], 'immunoglobulin-like': [139], 'domains': [140, 167], '(Ig1': [141], 'Ig4)': [143], 'MuSK.': [145, 169], 'two': [147], 'other': [148], 'they': [151], 'only': [153], 'Ig4': [155, 166], 'domain.': [156], 'bound': [161], 'Ig1': [164], 'Unexpectedly,': [170], 'AChE/ColQ': [172], 'suppressed': [178, 186], 'agrin/LRP4/MuSK': [179, 187], 'signaling.': [180], 'Quantitative': [181], 'analysis': [182], 'a': [190], 'greater': [191], 'extent': [192], 'than': [193], 'ColQ.': [194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2399700455', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-13T17:15:10.520958', 'created_date': '2016-06-24'}