Title: A meta-analysis on birth defects in both in vitro fertilization-embryo transfer infants and the naturally conceived children
Abstract: Objective To estimate the malformations vitro fertilization-embryo and naturally conceived children by means of meta-analysis, so as to provide the evidence for improving reproductive technology research. Methods We searched databases (ISI Web of Knowledge, Medline,CNKl) from 1999 to 2007 using in vitro or in vitro fertilization and embryo transfer ,in combination with congenital malformations, also performed a manual search of citations from relevant original studies. Then all the studies applied a recta-analysing with software of Stata 10.0. Results Eight publications were identified and found no heterogeneity (Q=3.57, P=0.83). The total rate of malformations was higher vitro fertilization-embryo infants than the naturally conceived. The pooled RR for the study was 1.34 (95% CI: 1.26 - 1.43, Z = 8.67, P = 0. 00). The cumulative summary effects showed that the larger the sample size, the more accurate the estimation. Publication bias were not found the study, by using Egger' s test method (P= 0.21 ).In dividing the type of the newborn malformations,the rate of cardiovascular defects in-vitro fertilization-embryo infants was higher than the naturally conceived. The summy RR for the study was 1.48(95% CI:1.25-1.76 ,Z =4. 53 ,P = 0. 00). Conclusions The total rate of malformations and the cardiovascular defects in-vitro fertilization-embryo infants was higher than the naturally conceived.
Key words:
Fertilization vitro; Embryo transfer; Abnormalities; Meta-analysis
Publication Year: 2009
Publication Date: 2009-06-01
Language: en
Type: article
Indexed In: ['pubmed']
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