Publication Information

{'id': 'https://openalex.org/W2398180612', 'doi': 'https://doi.org/10.1152/ajplung.1995.268.4.l647', 'title': 'Aberrant processing of surfactant protein C in hereditary SP-B deficiency', 'display_name': 'Aberrant processing of surfactant protein C in hereditary SP-B deficiency', 'publication_year': 1995, 'publication_date': '1995-04-01', 'ids': {'openalex': 'https://openalex.org/W2398180612', 'doi': 'https://doi.org/10.1152/ajplung.1995.268.4.l647', 'mag': '2398180612', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7537464'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajplung.1995.268.4.l647', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47245711', 'display_name': 'AJP Lung Cellular and Molecular Physiology', 'issn_l': '1040-0605', 'issn': ['1040-0605', '1522-1504'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035572005', 'display_name': 'D. K. Vorbroker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D. K. Vorbroker', 'raw_affiliation_strings': ["Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA."], 'affiliations': [{'raw_affiliation_string': "Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA.", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013795340', 'display_name': 'Sherri A. Profitt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. A. Profitt', 'raw_affiliation_strings': ["Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA."], 'affiliations': [{'raw_affiliation_string': "Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA.", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018295626', 'display_name': 'Lawrence M. Nogee', 'orcid': 'https://orcid.org/0000-0003-0540-8083'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L. M. Nogee', 'raw_affiliation_strings': ["Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA."], 'affiliations': [{'raw_affiliation_string': "Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA.", 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001813162', 'display_name': 'Jeffrey A. Whitsett', 'orcid': 'https://orcid.org/0000-0003-1668-5174'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. A. Whitsett', 'raw_affiliation_strings': ["Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA."], 'affiliations': [{'raw_affiliation_string': "Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA.", 'institution_ids': ['https://openalex.org/I1285204247']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 9.011, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 186, 'citation_normalized_percentile': {'value': 0.972427, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '268', 'issue': '4', 'first_page': 'L647', 'last_page': 'L656'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10549', 'display_name': 'Neonatal Respiratory Health Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10549', 'display_name': 'Neonatal Respiratory Health Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11456', 'display_name': 'Neuroscience of respiration and sleep', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10665', 'display_name': 'Cystic Fibrosis Research Advances', 'score': 0.9729, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/surfactant-protein-d', 'display_name': 'Surfactant protein D', 'score': 0.54572433}, {'id': 'https://openalex.org/keywords/polyclonal-antibodies', 'display_name': 'Polyclonal antibodies', 'score': 0.4661205}], 'concepts': [{'id': 'https://openalex.org/C2777961210', 'wikidata': 'https://www.wikidata.org/wiki/Q927148', 'display_name': 'Bronchoalveolar lavage', 'level': 3, 'score': 0.81510746}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.7303883}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.6544982}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.63969254}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.5862902}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5571656}, {'id': 'https://openalex.org/C2777438239', 'wikidata': 'https://www.wikidata.org/wiki/Q14914144', 'display_name': 'Surfactant protein D', 'level': 4, 'score': 0.54572433}, {'id': 'https://openalex.org/C956191', 'wikidata': 'https://www.wikidata.org/wiki/Q930144', 'display_name': 'Polyclonal antibodies', 'level': 3, 'score': 0.4661205}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.4606872}, {'id': 'https://openalex.org/C58226133', 'wikidata': 'https://www.wikidata.org/wiki/Q1324199', 'display_name': 'Pulmonary surfactant', 'level': 2, 'score': 0.453571}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4093361}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.28642315}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.20707735}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.14531526}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13821828}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12421703}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.12394929}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011510', 'descriptor_name': 'Proteolipids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011510', 'descriptor_name': 'Proteolipids', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011663', 'descriptor_name': 'Pulmonary Surfactants', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011663', 'descriptor_name': 'Pulmonary Surfactants', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000653', 'descriptor_name': 'Amniotic Fluid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000653', 'descriptor_name': 'Amniotic Fluid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001992', 'descriptor_name': 'Bronchoalveolar Lavage Fluid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001992', 'descriptor_name': 'Bronchoalveolar Lavage Fluid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000939', 'descriptor_name': 'Epitopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007106', 'descriptor_name': 'Immune Sera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007231', 'descriptor_name': 'Infant, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008970', 'descriptor_name': 'Molecular Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011510', 'descriptor_name': 'Proteolipids', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011510', 'descriptor_name': 'Proteolipids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011510', 'descriptor_name': 'Proteolipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011663', 'descriptor_name': 'Pulmonary Surfactants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011663', 'descriptor_name': 'Pulmonary Surfactants', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011663', 'descriptor_name': 'Pulmonary Surfactants', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011663', 'descriptor_name': 'Pulmonary Surfactants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012016', 'descriptor_name': 'Reference Values', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajplung.1995.268.4.l647', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47245711', 'display_name': 'AJP Lung Cellular and Molecular Physiology', 'issn_l': '1040-0605', 'issn': ['1040-0605', '1522-1504'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7537464', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4245983975', 'https://openalex.org/W4200419177', 'https://openalex.org/W317629203', 'https://openalex.org/W3131704014', 'https://openalex.org/W3122798221', 'https://openalex.org/W3030759040', 'https://openalex.org/W3029523220', 'https://openalex.org/W2583707022', 'https://openalex.org/W2185414853', 'https://openalex.org/W2117759917'], 'abstract_inverted_index': {'Hereditary': [0], 'surfactant': [1, 16, 40], 'protein': [2, 24], 'B': [3], '(SP-B)': [4], 'deficiency': [5, 147], 'causes': [6], 'lethal': [7], 'neonatal': [8], 'respiratory': [9, 166], 'disease': [10], 'associated': [11, 149, 168], 'with': [12, 31, 111, 138, 150, 169], 'abnormalities': [13], 'in': [14, 130], 'pulmonary': [15], 'proteins': [17, 49], 'and': [18, 70, 76, 83, 92, 114, 154], 'lipids.': [19], 'SP-C,': [20], 'a': [21, 27, 102], '4-kDa': [22], 'hydrophobic': [23], 'produced': [25, 46], 'from': [26, 95, 133], '21-kDa': [28], 'precursor,': [29], 'cooperates': [30], 'SP-B': [32, 146, 171], 'to': [33, 62, 164], 'enhance': [34], 'the': [35, 52, 59, 63, 112, 151, 165], 'surface': [36], 'active': [37, 115], 'properties': [38], 'of': [39, 89, 101, 105, 118, 156], 'phospholipids.': [41], 'Anti-proSP-C': [42], 'polyclonal': [43], 'antisera': [44], 'were': [45, 77], 'against': [47], 'fusion': [48], 'containing': [50], '1)': [51], 'amino': [53], 'terminus': [54], '(amino': [55, 67, 120], 'acids': [56, 68, 121], '1–20),': [57], '2)': [58], 'region': [60], 'carboxy-terminal': [61], 'mature': [64], 'SP-C': [65, 106, 119, 125, 159], 'peptide': [66, 116, 126], '58–77),': [69], '3)': [71], 'full-length': [72], '197-amino': [73], 'acid': [74], 'proSP-C': [75], 'characterized': [78], 'using': [79], 'immunoprecipitation,': [80], 'Western': [81, 86], 'blot,': [82], 'immunohistochemical': [84], 'techniques.': [85], 'blot': [87], 'analysis': [88], 'bronchoalveolar': [90, 131], 'lavage': [91, 132], 'amniotic': [93], 'fluid': [94], 'hereditary': [96, 170], 'SP-B-deficient': [97], 'patients': [98], 'allowed': [99], 'identification': [100], '12-kDa': [103, 124], 'form': [104], 'that': [107, 145], 'contained': [108], 'epitopes': [109], 'consistent': [110], 'amino-terminal': [113], 'regions': [117], '1–57).': [122], 'The': [123], 'was': [127], 'not': [128], 'detected': [129], 'healthy': [134], 'adults': [135, 137], 'or': [136, 141], 'alveolar': [139], 'proteinosis': [140], 'pneumonia.': [142], 'We': [143], 'conclude': [144], 'is': [148], 'aberrant': [152], 'processing': [153], 'secretion': [155], 'an': [157], 'immature': [158], 'peptide,': [160], 'which': [161], 'may': [162], 'contribute': [163], 'failure': [167], 'deficiency.': [172]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2398180612', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-14T21:14:46.217687', 'created_date': '2016-06-24'}