Title: Association between preoperative acute phase response and postoperative complications.
Abstract: To find out if there is an association between the acute phase response preoperatively and the development of postoperative infective complications.Prospective open study.Teaching hospital Germany.229 patients who were to undergo major abdominal operations.Measurements of serum concentrations of interleukin 6 (IL-6), alpha-1-antitrypsin, C-reactive protein (CRP), albumin, and prealbumin.Abnormal values of substances measured.Serum concentrations of IL-6, alpha-1-antitrypsin and CRP were raised, and those of albumin and prealbumin were reduced in 5% to 14% of patients. 25 (11%) developed major complications, of whom 9 (4%) died. 9 Patients (4%) had a severe systemic inflammatory response caused by infective complications that did not result from technical failure of the operative technique. Of these 9 patients, 7 (78%) already had signs of an increased acute phase response before operation that was significantly different from the incidence among patients who recovered without complications (21/204. p < 0.001)These data suggest that if there are signs of an acute phase response preoperatively the patient's response to operation and infection during the postoperative period may be adversely affected.
Publication Year: 1997
Publication Date: 1997-01-01
Language: en
Type: article
Indexed In: ['pubmed']
Access and Citation
Cited By Count: 47
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