Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2396078839', 'doi': 'https://doi.org/10.1038/nrclinonc.2016.64', 'title': 'Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect', 'display_name': 'Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect', 'publication_year': 2016, 'publication_date': '2016-05-17', 'ids': {'openalex': 'https://openalex.org/W2396078839', 'doi': 'https://doi.org/10.1038/nrclinonc.2016.64', 'mag': '2396078839', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27184418'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nrclinonc.2016.64', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S41981144', 'display_name': 'Nature Reviews Clinical Oncology', 'issn_l': '1759-4774', 'issn': ['1759-4774', '1759-4782'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025020524', 'display_name': 'Guido Bocci', 'orcid': 'https://orcid.org/0000-0001-7120-9141'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Guido Bocci', 'raw_affiliation_strings': ['Divisione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Via Roma, 55, Pisa, I-56126, Italy'], 'affiliations': [{'raw_affiliation_string': 'Divisione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Via Roma, 55, Pisa, I-56126, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010799165', 'display_name': 'Robert S. Kerbel', 'orcid': 'https://orcid.org/0000-0002-6015-2570'}, 'institutions': [{'id': 'https://openalex.org/I1323843004', 'display_name': 'Sunnybrook Health Science Centre', 'ror': 'https://ror.org/03wefcv03', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1323843004']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Robert S. Kerbel', 'raw_affiliation_strings': ['Sunnybrook Research Institute/Odette Cancer Centre, Biologic Sciences Platform, S-217, 2075 Bayview Avenue, Toronto, M4N 3M5, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Sunnybrook Research Institute/Odette Cancer Centre, Biologic Sciences Platform, S-217, 2075 Bayview Avenue, Toronto, M4N 3M5, Ontario, Canada', 'institution_ids': ['https://openalex.org/I1323843004']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5025020524'], 'corresponding_institution_ids': ['https://openalex.org/I108290504'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.427, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 169, 'citation_normalized_percentile': {'value': 0.999402, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '13', 'issue': '11', 'first_page': '659', 'last_page': '673'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11752', 'display_name': 'Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11752', 'display_name': 'Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'DNA Topoisomerases: Structure, Function, and Inhibition', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/drug-metabolism', 'display_name': 'Drug Metabolism', 'score': 0.477931}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9066857}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.7701715}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.6364784}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.58858407}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.57794297}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.50020146}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.4634734}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.41000193}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.37837788}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.37397072}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36632118}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D059250', 'descriptor_name': 'Administration, Metronomic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000477', 'descriptor_name': 'Alkylating Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000477', 'descriptor_name': 'Alkylating Agents', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000477', 'descriptor_name': 'Alkylating Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000477', 'descriptor_name': 'Alkylating Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017326', 'descriptor_name': 'Clinical Trials, Phase III as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005544', 'descriptor_name': 'Forecasting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007111', 'descriptor_name': 'Immunity, Cellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007111', 'descriptor_name': 'Immunity, Cellular', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016032', 'descriptor_name': 'Randomized Controlled Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050257', 'descriptor_name': 'Tubulin Modulators', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D050257', 'descriptor_name': 'Tubulin Modulators', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D050257', 'descriptor_name': 'Tubulin Modulators', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D050257', 'descriptor_name': 'Tubulin Modulators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nrclinonc.2016.64', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S41981144', 'display_name': 'Nature Reviews Clinical Oncology', 'issn_l': '1759-4774', 'issn': ['1759-4774', '1759-4782'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27184418', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 151, 'referenced_works': ['https://openalex.org/W103592546', 'https://openalex.org/W1254987090', 'https://openalex.org/W1545272734', 'https://openalex.org/W1556819620', 'https://openalex.org/W1572722780', 'https://openalex.org/W1573738975', 'https://openalex.org/W1581101298', 'https://openalex.org/W1595263809', 'https://openalex.org/W1602594295', 'https://openalex.org/W1645010355', 'https://openalex.org/W1747872002', 'https://openalex.org/W1752179525', 'https://openalex.org/W1765129328', 'https://openalex.org/W1793615273', 'https://openalex.org/W1819686384', 'https://openalex.org/W1834561952', 'https://openalex.org/W1836451026', 'https://openalex.org/W1892571469', 'https://openalex.org/W1898325617', 'https://openalex.org/W1912790728', 'https://openalex.org/W1928747779', 'https://openalex.org/W1929987490', 'https://openalex.org/W1943173994', 'https://openalex.org/W1965580236', 'https://openalex.org/W1966175442', 'https://openalex.org/W1971822071', 'https://openalex.org/W1972146805', 'https://openalex.org/W1973091654', 'https://openalex.org/W1973324434', 'https://openalex.org/W1975222023', 'https://openalex.org/W1977356115', 'https://openalex.org/W1977857458', 'https://openalex.org/W1978853965', 'https://openalex.org/W1979214520', 'https://openalex.org/W1984750597', 'https://openalex.org/W1991996995', 'https://openalex.org/W1994299856', 'https://openalex.org/W1995047633', 'https://openalex.org/W1995556774', 'https://openalex.org/W1998261391', 'https://openalex.org/W1999652608', 'https://openalex.org/W2000160810', 'https://openalex.org/W2000200648', 'https://openalex.org/W2002052785', 'https://openalex.org/W2003549650', 'https://openalex.org/W2006350851', 'https://openalex.org/W2007480962', 'https://openalex.org/W2008288621', 'https://openalex.org/W2009116016', 'https://openalex.org/W2010293565', 'https://openalex.org/W2013492504', 'https://openalex.org/W2017781182', 'https://openalex.org/W2018368471', 'https://openalex.org/W2020974878', 'https://openalex.org/W2023555639', 'https://openalex.org/W2024447346', 'https://openalex.org/W2029883816', 'https://openalex.org/W2032031944', 'https://openalex.org/W2037813108', 'https://openalex.org/W2038544543', 'https://openalex.org/W2044884111', 'https://openalex.org/W2045594601', 'https://openalex.org/W2047727316', 'https://openalex.org/W2049898667', 'https://openalex.org/W2050555289', 'https://openalex.org/W2050633295', 'https://openalex.org/W2051701101', 'https://openalex.org/W2053371370', 'https://openalex.org/W2053649039', 'https://openalex.org/W2054297703', 'https://openalex.org/W2054953072', 'https://openalex.org/W2056271276', 'https://openalex.org/W2059568170', 'https://openalex.org/W2062601742', 'https://openalex.org/W2065895655', 'https://openalex.org/W2067869945', 'https://openalex.org/W2069419271', 'https://openalex.org/W2074470232', 'https://openalex.org/W2075549113', 'https://openalex.org/W2075959323', 'https://openalex.org/W2078448383', 'https://openalex.org/W2078786745', 'https://openalex.org/W2079867625', 'https://openalex.org/W2082069505', 'https://openalex.org/W2082242105', 'https://openalex.org/W2082412368', 'https://openalex.org/W2083870878', 'https://openalex.org/W2087525057', 'https://openalex.org/W2087800680', 'https://openalex.org/W2088452019', 'https://openalex.org/W2089117117', 'https://openalex.org/W2092998745', 'https://openalex.org/W2094717969', 'https://openalex.org/W2098464561', 'https://openalex.org/W2100256308', 'https://openalex.org/W2101747469', 'https://openalex.org/W2102392974', 'https://openalex.org/W2102541302', 'https://openalex.org/W2102782790', 'https://openalex.org/W2103158778', 'https://openalex.org/W2103164470', 'https://openalex.org/W2114592067', 'https://openalex.org/W2114675702', 'https://openalex.org/W2114903378', 'https://openalex.org/W2118365548', 'https://openalex.org/W2119018891', 'https://openalex.org/W2119900319', 'https://openalex.org/W2124343455', 'https://openalex.org/W2131560485', 'https://openalex.org/W2136571444', 'https://openalex.org/W2137049683', 'https://openalex.org/W2137268781', 'https://openalex.org/W2137417501', 'https://openalex.org/W2137519349', 'https://openalex.org/W2138991012', 'https://openalex.org/W2139240866', 'https://openalex.org/W2139671097', 'https://openalex.org/W2142616277', 'https://openalex.org/W2145619143', 'https://openalex.org/W2147711740', 'https://openalex.org/W2150310748', 'https://openalex.org/W2155343550', 'https://openalex.org/W2156675827', 'https://openalex.org/W2156902079', 'https://openalex.org/W2156947598', 'https://openalex.org/W2157830465', 'https://openalex.org/W2161204192', 'https://openalex.org/W2162475347', 'https://openalex.org/W2162581011', 'https://openalex.org/W2162661389', 'https://openalex.org/W2162875441', 'https://openalex.org/W2163649778', 'https://openalex.org/W2163899134', 'https://openalex.org/W2163940216', 'https://openalex.org/W2168255288', 'https://openalex.org/W2169965478', 'https://openalex.org/W2170193835', 'https://openalex.org/W2179271336', 'https://openalex.org/W2242853197', 'https://openalex.org/W2263360618', 'https://openalex.org/W2316822889', 'https://openalex.org/W2333534468', 'https://openalex.org/W2399229886', 'https://openalex.org/W2492098716', 'https://openalex.org/W2586296107', 'https://openalex.org/W2601786697', 'https://openalex.org/W2601844941', 'https://openalex.org/W2907132226', 'https://openalex.org/W349917292', 'https://openalex.org/W4210952837', 'https://openalex.org/W4244823884'], 'related_works': ['https://openalex.org/W2991030316', 'https://openalex.org/W2908757458', 'https://openalex.org/W2887865523', 'https://openalex.org/W2365579252', 'https://openalex.org/W2361661556', 'https://openalex.org/W2352350815', 'https://openalex.org/W2189230703', 'https://openalex.org/W2162888433', 'https://openalex.org/W2114878163', 'https://openalex.org/W2112528869'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2396078839', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 24}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 24}, {'year': 2017, 'cited_by_count': 26}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-01T05:54:10.998362', 'created_date': '2016-06-24'}