Title: Study on cardioprotection of ramipril against ischemia/reperfusion injury in diabetic rats
Abstract: Aim To investigate the effect of ramipril on myocardial ischemia-reperfusion injury in diabetic rats.Methods Streptozotocin induced diabetic rats were divided randomly into ischemia/reperfusion(I/R),ischemic preconditioning(IPC) and ramipril(RAM) groups.Rats in RAM group were administered RAM(1 mg·kg-1) orally for 4 weeks,the others were administered normal saline.Then all rats were subjected to myocardial ischemia/reperfusion injury.Rats in IPC group were preconditioned before ischemia.ECG,myocardial infarct size,apoptosis and expressions of Bcl-2 and Bax,changes of myocardial morphology were examined.Results Compared with those of I/R group,the elevation of ST segment and the incidence of ventricular tachycardia and ventricular fibrillation during ischemia were significantly decreased,myocardial infarct size and cardiomyocyte apoptosis index were remarkably reduced,ratio of Bcl-2/Bax was increased in both IPC and RAM groups.Conclusion Myocardial ischemia/reperfusion injury was decreased in diabetic rats after ramipril orally administered for 4 weeks.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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