Title: THE RELATIONSHIP BETWEEN SERUM LEPTIN LEVEL AND METABOLIC FACTORS IN WOMEN WITH TYPE 2 DIABETES
Abstract:Objective To observe the serum leptin levels in women with type 2 diabetes mellitus(DM) at preliminary diagnosis and to evaluate the possible relationships to body mass index (BMI), age, glycometaboli...Objective To observe the serum leptin levels in women with type 2 diabetes mellitus(DM) at preliminary diagnosis and to evaluate the possible relationships to body mass index (BMI), age, glycometabolism, lipometabolism, uric acid metabolism and some hormones. Methods By using radioimmunoassay(RIA) and enzyme linked immunosorbent assay(ELISA) methods, the fasting serum levels of leptin, testosterone (TT), estradiol (E 2), true insulin, blood glucose(FBG), cholesterol, triglycerid and uric acid were measured in 96 healthy subjects and 111 patients with type 2 diabetes. All patients were newly diagnosed and untreated before. Results The serum leptin level was significantly lower in DM group than normal controls in women( F= 17.985 ,P 0.01);in DM and control groups, the serum leptin levels were significantly higher in women than men ( F= 34.608 ,53.721; P 0.01); no significant difference of serum leptin levels between premenopausal and postmenopausal women with DM ; in DM group, the serum leptin level was positively correlated with BMI, true insulin concentration, WHR, uric acid ( t= 4.075-11.725; P 0.01, 0.05) and negatively correlated with FBG and TT ( t=-3.946-2.305,P 0.05). Conclusion The serum leptin level is significantly lower in women with type 2 diabetes than normal women, which correlates with BMI, body fat distribution, insulin concentration, TT, blood glucose and uric acid. Estradiol is not a principal factor influencing serum leptin. Leptin is involved in glycometabolism and uric acid metabolism in women with the disease.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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