Title: Screening and Biological Characteristics of Virus Seed for Preparation of Vero cell-derived Tick-borne Encephalitis Vaccine
Abstract: Objective To screen an appropriate virus seed for the preparation of Vero cell-derived tick-borne encephalitis vaccine.Methods The current virus strain Sen-Zhang for preparation of tick-borne encephalitis vaccine was subcultured in Vero cells,and the titers,immunogenicities and stabilities of virus of various passages were studied.Results The virus titer of Sen-Zhang strain adapted in Vero cells reached 8.5 LgLD_ 50 /ml.The serum neutralizing antibody titer of mice immunized with the strain reached more than 1∶20 .All the quality indexes of the adapted strain met the requirements for virus seeds for vaccine production.Conclusion The Vero cell-adapted Sen-Zhang stain might be used as a virus seed for preparation of Vero cell-derived tick-borne encephalitis vaccine.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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