Title: Expression of metastasis-associated gene CD44v6 in prostate cancer tissue
Abstract:AIM To evaluate the expression of metastasis associated gene CD44v6 in prostate cancer tissue and its significance. METHODS The expression of CD44v6 in 67 human prostate cancer specimens was studied b...AIM To evaluate the expression of metastasis associated gene CD44v6 in prostate cancer tissue and its significance. METHODS The expression of CD44v6 in 67 human prostate cancer specimens was studied by immunohis tochemical S P technique. RESULTS The positive rate of CD44v6 was 41.8%(28/67). The positive staining was higher in metastasis patients (57.1%) than in patients without metastasis (16.0%) of prostate cancer ( P 0.01). The expression of CD44v6 was correlated with cell grade ( r= 0.463, P0.05 ) and clinical stage ( r=0.412, P0.05 ) of the tumour. The life expectancy of CD44v6 positive staining patients with prostate cancer was shorter than that of CD44v6 negative patients (9.5% vs 39.3%, P0.05 ). CONCLUSION The expression of CD44v6 gene is possibly related to the carcinogenesis, progress and prognosis of prostate cancer.Read More
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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